Nano-silver target drug feeding system loaded with curcumin or curcumin derivative

A curcumin derivative and targeted drug delivery technology, applied in the field of biomedicine, can solve problems such as inability to efficiently reach the lesion site, treatment failure, decreased immunity, etc., to improve solubility and bioavailability, and improve therapeutic effect. , the effect of reducing toxic side effects

Inactive Publication Date: 2016-01-06
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many compounds have good anti-tumor activity in vitro, they cannot efficiently reach the lesion site in vivo, or non-selectively damage normal cells while reaching the lesi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Combining anti-tumor drugs with curcumin and nano-silver in a weight percentage of 1:0.01, curcumin and nano-silver are administered as a joint component through a targeted system; combined anti-tumor drugs and methoxypolyethylene glycol-polylactic acid Amphiphilic block copolymer (MPEG-PLA) by weight percentage 1:5, methoxy polyethylene glycol-polylactic acid amphiphilic block copolymer (MPEG-PLA) and MUC1 nucleic acid aptamer by weight percentage 1 :0.5, obtain curcumin nano-silver targeted drug delivery system through the following steps:

[0026](1) Bonding of MUC1 nucleic acid aptamer to methoxypolyethylene glycol-polylactic acid amphiphilic block copolymer (MPEG-PLA): Nucleic acid aptamer and polymer use excess 1-ethyl -Incubate 3-(3-dimethylaminopropyl)carbodiimide (EDC) and NHS at room temperature to obtain NHS activated bonding to obtain MUC1 nucleic acid aptamer-MPEG-PLA, namely (MPEG-PLA-Apt);

[0027] (2) Weigh MPEG-PLA-Apt according to the prescription and...

Embodiment 2

[0030] Tetrahydrocurcumin and nano-silver are used as a combined antineoplastic drug in a percentage by weight of 1:0.5, and tetrahydrocurcumin and nano-silver are administered through a targeted drug delivery system; combined anticancer drug and polylactide-glycolide- Polyethylene glycol-polylactide-glycolide block copolymer (PLGA-PEG-PLGA) by weight percentage 1:25, polylactide-glycolide-polyethylene glycol-polylactide-glycolide The block copolymer (PLGA-PEG-PLGA) and the MUC1 nucleic acid aptamer are 1:20 by weight, and the tetrahydrocurcumin nano-silver targeted drug delivery system is obtained through the following steps:

[0031] (1) Bonding of SZTI01 nucleic acid aptamer to polylactide-glycolide-polyethylene glycol-polylactide-glycolide block copolymer (PLGA-PEG-PLGA): SZTI01 nucleic acid aptamer and The polymer was incubated with excess 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and NHS at room temperature to obtain NHS activated bonding to obtain SZTI01 nucl...

Embodiment 3

[0035] Using hexahydrocurcumin and nano silver as a combined antineoplastic drug in a weight percentage of 1:0.25, hexahydro curcumin and nano silver are administered through a targeted drug delivery system; combined anticancer drugs and polyethylene glycol-polylactide -glycolide-polyethylene glycol block copolymer (PEG-PLGA-PEG) by weight percentage 1:30, polyethylene glycol-polylactide-glycolide-polyethylene glycol block copolymer (PEG -PLGA-PEG) and A10 nucleic acid aptamer at a ratio of 1:15 by weight, and the hexahydrocurcumin nanosilver targeted drug delivery system was obtained through the following steps:

[0036] (1) Bonding of A10 nucleic acid aptamer to polyethylene glycol-polylactide-glycolide-polyethylene glycol block copolymer (PEG-PLGA-PEG): A10 nucleic acid aptamer and polymer polymerization The substance was incubated with excess 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and NHS at room temperature to obtain NHS activated bonding to obtain A10 nucle...

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Abstract

The invention relates to a target drug feeding system with combination of nano-silver and curcumin or a curcumin derivative and belongs to the technical field of biological medicines. The nano-silver target drug feeding system particularly takes an aptamer as a target point; the curcumin or the curcumin derivative or the nano silver is used as a combined anti-tumor drug and is polymerized to the outer surface of a biodegradable high-molecular polymer nano-system (PNS) by the aptamer to synthesize an aptamer-PNS polymer which is used as a shell; the PNS simultaneously encapsulates the curcumin or the curcumin derivative and the nano silver, so as to prepare the nano-silver target drug feeding system which is loaded with active components including the curcumin or the curcumin derivative and improve the solubility and bioavailability of the curcumin and the curcumin derivative; meanwhile, drugs can be targeted into non-small-cell lung cancer cells or prostate cancer cells; the anti-tumor effects of the curcumin or the curcumin derivative and the nano silver are expressed so that the target drug feeding and drug slow releasing effects are realized; the nano-silver target drug feeding system is used for preventing and treating lung cancers and prostatic cancers, the treatment effect is improved and the toxic side effect is reduced.

Description

technical field [0001] The invention relates to a targeted drug delivery system, in particular to a targeted drug delivery system composed of curcumin or curcumin derivatives and nano-silver, which is used for the prevention and treatment of lung cancer and prostate cancer, and belongs to the technical field of biomedicine. Background technique [0002] In China, the number of deaths due to lung cancer is more than the sum of deaths from breast cancer, prostate cancer and intestinal cancer, among which the prevalence of non-small cell lung cancer is the highest. Current lung cancer treatment methods can achieve a certain degree of control, but the overall curative effect is not great. In addition to the high toxicity and side effects, there is also a certain degree of recurrence risk. More than 80% of lung cancer patients are diagnosed or treated too late, missing surgery and radical cure. best time. Therefore, the development of lung cancer treatment means is crucial. Pro...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K47/34A61P35/00A61K33/38
Inventor 何燕马诗经张焜程书朋江森武文敬月圆王辉郑希霍延平杜志云方岩雄
Owner GUANGDONG UNIV OF TECH
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