Method for quickly manufacturing titanium alloy artificial biological joint

Abstract

The invention provides a method for quickly manufacturing a titanium alloy artificial biological joint. A three-dimensional model of an affected part joint in the body of a patient is obtained through CT scanning, and the model is amplified in a corresponding proportion according to a contraction ratio; then, an elastic cavity negative mould of the joint is quickly manufactured through 3D printing, titanium alloy powder is evenly and loosely contained in the cavity negative mould in the argon environment and sealed, and a porous titanium alloy joint blank is manufactured through high-pressure cold isostatic pressing; titanium alloy slurry in different particle sizes and even in the nano scale is sprayed to the surface of the blank to build a porosity gradient surface layer; and then, the joint blank is biologically modified through biological agent slurry, the blank is subjected to vacuum drying, degreasing and sintering after surface treatment, and the porous titanium alloy artificial biological joint is obtained. According to personal data, the appearance of the joint is customized, and the joint is good in biological adaptation. Through porosity gradient structural design and biological modification, the joint is good in biocompatibility. Through an oxygen control means, the joint is small in impurity content and high in performance. The production period is short, process stability is high, repeatability is good, and cost is low.

Description

technical field [0001] The invention provides a rapid manufacturing method of a titanium alloy artificial biological joint, which belongs to the biomedical field of rapid prototyping technology, and in particular provides a cold isostatic pressing forming-vacuum sintering process of a 3D printing negative mold to manufacture a biological joint of a specific shape Methods. Background technique [0002] Titanium has the characteristics of low elastic modulus, high fatigue strength, high toughness, high strength and good biocompatibility, and has been used clinically as a biological implant. To prepare titanium alloy bio-joints suitable for individual physique, there are currently three problems: one is the problem of shape matching, the shape of bio-joints varies from person to person, and the mass-produced artificial joints cannot match each individual's specific situation; The second is the problem of human bone structure. Human bone is a structure with a dense outer layer ...

AI Technical Summary

Problems solved by technology

To prepare titanium alloy bio-joints suitable for individual physique, there are currently three problems: one is the problem of shape matching, the shape of bio-joints varies from person to person, and the mass-produced artificial joints cannot match each individual's specific situation; The second is the problem of human bone structure. Human bone is a structure with a dense outer layer and a looser inner layer. The dense bone bears a large amount of load, while the loose bone is conducive to the metabolism and growth of bone tissue. Therefore, the joint implant needs to be designed to have a gradient of pores. structure; the third is the growth and metabolism of bone tissue. Compared with the bone made of inorganic and organic matter, titanium alloy as a metal has a completely different internal structure and lacks osteoinductive ability and biological activity. Titanium alloys are directly implanted into the human body After that, it is difficult to form a strong fibrous tissue membrane with bone tissue

[0013] After nearly 30 years of literature search, no 3D printing cavity negative mold was used for cold isostatic high-pressure forming, and titanium alloy biological coating was applied to the parison by vacuum drying-degreasing-sintering process. Patents and Reports on Joint Manufacturing