Graphene oxide modified by betaine type zwitterionic compound and preparation method thereof

A technology of zwitterions and compounds, which is applied in the field of nanomaterial surface modification and biomedical materials, can solve the problems of difficulty in controlling the grafting rate of zwitterions on the surface of graphene oxide and poor reaction selectivity, and achieve good biocompatibility and reaction Mild conditions and strong reaction selectivity

Active Publication Date: 2017-12-01
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has problems such as poor reaction selectivity and difficulty in controlling the grafting rate of zwitterions on the surface of graphene oxide.

Method used

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  • Graphene oxide modified by betaine type zwitterionic compound and preparation method thereof
  • Graphene oxide modified by betaine type zwitterionic compound and preparation method thereof
  • Graphene oxide modified by betaine type zwitterionic compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Preparation of thiolated graphene oxide: Mix 3.0g flake graphite and 18.0g potassium permanganate evenly, add to the flask, and add 400mL of 98% concentrated sulfuric acid and phosphoric acid dropwise while stirring under ice bath conditions (Volume ratio is 8:1) mixture, then heated up to 50°C, reacted for 12 hours; when the reaction system returned to room temperature, the resulting mixture was poured into 400mL of ice water at 0°C, and 30% hydrogen peroxide solution was added dropwise to The mixture is golden yellow and there are no more bubbles; the product obtained is washed with dilute hydrochloric acid and deionized water, and centrifuged until the supernatant is neutral; the supernatant is removed, and the product obtained by centrifugation is dried to obtain graphite oxide . Ultrasonic disperse 200mg of graphite oxide in 180mL of absolute ethanol to obtain a graphene oxide dispersion, and adjust its pH to 4 with dilute hydrochloric acid; take 1.003g (5.102m...

Embodiment 2

[0041] (1) Preparation of thiolated graphene oxide: Mix 3.0g expanded graphite and 9.0g potassium permanganate evenly, add to the flask, and add 400mL of 98% concentrated sulfuric acid and phosphoric acid dropwise while stirring under ice bath conditions (Volume ratio is 6:1) mixture, then heated up to 60 ° C, reacted for 6 hours; when the reaction system returned to room temperature, the resulting mixture was poured into 400 mL of ice water at 0 ° C, and 20% hydrogen peroxide solution was added dropwise to The mixture is golden yellow and there are no more bubbles; the product obtained is washed with dilute hydrochloric acid and deionized water, and centrifuged until the supernatant is neutral; the supernatant is removed, and the product obtained by centrifugation is dried to obtain graphite oxide . Ultrasonic disperse 200mg of graphite oxide in 180mL of methanol to obtain a graphene oxide dispersion, and adjust its pH to 2 with dilute hydrochloric acid; take 0.202g (1.099mmo...

Embodiment 3

[0046] (1) Preparation of mercaptolated graphene oxide: 3.0 g of pre-oxidized graphite and 24.0 g of potassium permanganate were mixed uniformly, added to the flask, and under ice-bath conditions, 400 mL of 98% concentrated sulfuric acid was added dropwise while stirring and Phosphoric acid (volume ratio: 12:1) mixture, then heated to 70°C, reacted for 24 hours; after the reaction system returned to room temperature, poured the resulting mixture into 400mL of ice water at 0°C, and added 40% hydrogen peroxide solution dropwise until the mixture is golden yellow and there are no more bubbles; the product obtained is washed with dilute hydrochloric acid and deionized water, and centrifuged until the supernatant is neutral; the supernatant is removed, and the product obtained by centrifugation is dried to obtain oxidation graphite. Ultrasonic disperse 200mg of graphite oxide in 180mL of isopropanol to obtain a graphene oxide dispersion, and adjust its pH to 6 with dilute hydrochlo...

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Abstract

The invention discloses graphene oxide modified by a betaine type zwitterionic compound and a preparation method thereof. The preparation method is as follows: firstly, the surface of graphene oxide is subjected to mercapto-treatment by hydrolysis of a mercapto-containing silane coupling agent; then, ethylene-based carboxylic acid or sulfonate betaine-type The zwitterionic compound is grafted onto the surface of the graphene oxide to obtain the graphene oxide modified by the betaine type zwitterionic compound. The betaine-type zwitterionic compound-modified graphene oxide prepared by the present invention not only has excellent biocompatibility, but also has a simple and easy preparation method, high reaction efficiency and selectivity, easy regulation, and simple post-treatment of the product. convenient. This approach provides a new avenue to improve the biocompatibility of graphene oxide. The graphene oxide modified by the betaine-type zwitterionic compound will have broad application prospects in the fields of biomedical materials such as medical devices, tissue engineering scaffolds, drug sustained release, and anti-bacterial adhesion.

Description

technical field [0001] The invention relates to graphene oxide, in particular to graphene oxide modified by a betaine-type zwitterionic compound and a preparation method thereof, belonging to the technical fields of surface modification of nanometer materials and biomedical materials. Background technique [0002] With the development of biomedical technology, people's demand for biomedical materials (such as bone graft materials, kidney permeable membranes, cardiac pacemakers, tissue engineering scaffolds, etc.) is increasing. However, due to their poor biocompatibility, most materials are prone to non-specific adsorption of proteins in organisms, which can cause blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in their performance and even endangering human health. Therefore, biocompatibility is crucial for the application of biomaterials and has been receiving much attention in the research of biomaterials. The charge, affinity / hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B32/198
Inventor 李光吉陈志锋王立莹黄瑞冰张子勋
Owner SOUTH CHINA UNIV OF TECH
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