Preparation method of functional hydrogel medical dressing

Abstract

The invention discloses a preparation method of a functional hydrogel medical dressing. The preparation method comprises the following steps: 1. blending a biopolymer material, a chemical synthesized polymer material, a transforming growth factor TGF-beta and distilled water so as to form a physical-crosslinked hydrogel, wherein the biopolymer material consists of carboxymethyl chitosan, chitosan quaternary ammonium salt, gelatin, gellan gum and sodium alginate; and the chemical synthesized polymer material consists of polyvinyl alcohol and polyvinylpyrrolidone; 2. coating and processing the physical-crosslinked hydrogel obtained in the step 1 by virtue of a coating machine; and 3. conducting radiation sterilization on the hydrogel which is coated in the step 2, and implementing radiation crosslinking during the process of radiation sterilization. The method, through physical crosslinking and radiation crosslinking, can form the hydrogen of a dual-network structure; and the hydrogel medical dressing is high in strength and melting-up property, and the dressing is capable of protecting wound surfaces, stopping bleeding, relieving pain, inhibiting bacteria and promoting the growth of epithelial cell.

Description

technical field [0001] The invention relates to a medical dressing for treating sores, wounds or other injuries, in particular to a method for manufacturing a functional hydrogel medical dressing. Background technique [0002] Medical dressings are a class of important medical materials used to cover sores, wounds or other injuries. They can replace damaged skin to act as a temporary barrier, avoid or control wound infection, and provide an environment conducive to wound healing. New medical dressings combine advanced knowledge of biology, physiology, surgery, nursing and nutrition, and apply various actual needs of patients for dressings, such as physical and clinical, to the material selection and shape design of dressings. The new dressings are divided into films, alginates, foams, hydrocolloids, medicinal dressings and hydrogels. [0003] Film dressings are transparent, easy to observe the wound, can closely adhere to the wound surface, effectively retain the wound exud...

AI Technical Summary

Problems solved by technology

The hydrogels currently used are basically made by one of chemical cross-linking, radiation cross-linking and physical cross-linking. The hydrogel synthesized by a single method contains a large amount of water to increase the molecular chain length between cross-linking points. Factors such as too wide distribution lead to low mechanical strength of the hydrogel and are very brittle, and chemical cross-linking inevitably introduces cross-linking agents, initiators, and organic solvents during the synthesis process, which will increase the toxicity of the gel system

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