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Silica-coated Prussian blue nanoparticles, preparation method and application thereof

A Prussian blue-like, nanoparticle technology, applied to Prussian blue-like nanoparticles and their preparation, and the clinical application of magnetic resonance and photoacoustic dual-function imaging contrast agents, can solve the biological toxicity, the organic layer is easily destroyed, Insoluble in water and other problems, to achieve the effect of improving stability, improving biocompatibility, and simple and easy operation

Active Publication Date: 2018-03-27
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Existing Prussian blue nanoparticles also have some defects, for example: water-soluble KFe[Fe(CN) 6 ] Due to the presence of potassium ions, intravenous application is limited; while Fe 4 [Fe(CN) 6 ] 3 insoluble in water
For the research on the protection and modification of Prussian blue nanoparticles, most of the current studies use non-water-soluble organic substances, and the Prussian blue nanoparticles wrapped by water-soluble organic substances adopt the method of electrostatic adsorption. It is easy to be destroyed to form bare Prussian blue nanoparticles, which are insoluble in water environment and easy to be cleared by the body. Toxic effects of

Method used

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  • Silica-coated Prussian blue nanoparticles, preparation method and application thereof
  • Silica-coated Prussian blue nanoparticles, preparation method and application thereof

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Embodiment 1

[0040] This embodiment provides a method for preparing silica-coated Prussian blue-like nanoparticles, comprising the following steps:

[0041] Step 1: Preparation of Prussian blue-like nanoparticles

[0042] (1) Potassium ferricyanide and citric acid are dissolved in ethanol, and after mixing and stirring evenly, a solution is prepared, wherein every milliliter of solution A contains 0.006g of potassium ferricyanide and 0.012g of citric acid;

[0043] (2) Dissolving zinc methacrylate in a solvent, mixing and stirring evenly, is prepared into solution B, wherein every milliliter of solution B contains 0.018 g of zinc methacrylate;

[0044] (3) Magnetically stir the B solution evenly, heat it to 80° C. and reflux for 1 h, then add the A solution dropwise, adjust the reaction temperature to 20° C., magnetically stir the reaction for 4 h, and centrifuge to obtain the Prussian blue-like nanoparticles C. It is dissolved in ethanol until completely dissolved, thereby obtaining a so...

Embodiment 2

[0050] This embodiment provides a method for preparing silica-coated Prussian blue-like nanoparticles, comprising the following steps:

[0051] Step 1: Preparation of Prussian blue-like nanoparticles

[0052] (1) Potassium ferrocyanate and tartaric acid are dissolved in water, mixed and stirred evenly, and prepared into solution A, wherein every milliliter of solution A contains 0.008g of potassium ferrocyanide and 0.016g of tartaric acid;

[0053] (2) Dissolving zinc methacrylate in water, mixing and stirring evenly, is prepared into solution B, wherein every milliliter of solution B contains 0.02 g of zinc methacrylate;

[0054] (3) Magnetically stir the B solution evenly, heat to 70°C and reflux for 2h, then add the A solution dropwise, adjust the reaction temperature to 50°C, magnetically stir the reaction for 2h, and centrifuge to obtain the Prussian blue nanoparticle C. It is dissolved in ethanol until completely dissolved, thereby obtaining a solution of Prussian blue ...

Embodiment 3

[0060] This embodiment provides a method for preparing silica-coated Prussian blue-like nanoparticles, comprising the following steps:

[0061] Step 1: Preparation of Prussian blue-like nanoparticles

[0062] (1) dissolving sodium ferricyanide and malic acid in ethylene glycol, mixing and stirring evenly, and preparing solution A, wherein every milliliter of solution A contains 0.008 g of sodium ferricyanide and 0.02 g of malic acid;

[0063] (2) Zinc methacrylate is dissolved in ethylene glycol, and after mixing and stirring evenly, it is prepared into solution B, wherein every milliliter of solution B contains 0.02 g of zinc methacrylate;

[0064] (3) Magnetically stir the B solution evenly, heat it to 90° C. and reflux for 1 h, then add the A solution dropwise, adjust the reaction temperature to 100° C., magnetically stir the reaction for 4 h, and centrifuge to obtain Prussian blue nanoparticles C. It is dissolved in ethanol until completely dissolved, thereby obtaining a ...

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Abstract

The invention provides silicon dioxide-coated prussian blue analogue nano-particles and a preparation method thereof. The preparation method comprises the steps that prussian blue analogue nano-particles with double bonds on the surfaces are synthesized by taking hexacyanoferrate acid substances and zinc salt as raw materials, then the surfaces of the nano-particles are coated with organosilicone monolayers through a free radical polymerization reaction, silicon dioxide layers are formed through an ammonia water catalytic polycondensation reaction, and then the silicon dioxide-coated prussian blue analogue nano-particles are prepared. The invention further provides clinical application of the nano-particles in magnetic resonance and photoacoustic dual-function imaging as a contrast agent. The preparation method is mild in reaction condition, and no other poisonous or harmful by-product exists; the inner nuclear layers and the shell layers of the prepared nano-particles are connected through silicon-oxygen covalent bonds, the prepared nano-particles are very stable under physical conditions, and the biocompatibility and the imaging signal stability are improved; in addition, the surfaces of the nano-particles are provided with functional groups such as amino groups or sulfhydryl groups, so that very beneficial conditions are supplied to further surface modifying and antibody grafting.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a silicon dioxide-wrapped Prussian blue-like nanoparticle and a preparation method thereof, as well as its clinical application as a magnetic resonance and photoacoustic dual-function imaging contrast agent. Background technique [0002] The application of nanomaterials in the field of biomedicine, especially in medical diagnosis and treatment, has attracted more and more attention. Nanomaterials are expected to solve the limitations of traditional biomedical methods. However, the current research on nanomaterials is limited to in vitro experiments, and its biological safety in the human body cannot be guaranteed, which severely limits its further development. Solving the biological safety of nanomaterials has become a key issue in the application of nanomaterials in the field of biomedicine. [0003] Prussian blue is an ancient dye with low price. It is widely us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K49/18B82Y5/00B82Y15/00
CPCA61K49/183A61K49/225B82Y5/00B82Y15/00
Inventor 张华娟宋亮
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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