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Preparing method for fresh lumbricus extract

A technology of extract and earthworm, applied in the field of preparation of fresh earthworm extract, can solve the problems of few preparation methods of fresh earthworm extract, waste of medicinal materials, and improvement of extraction methods

Active Publication Date: 2016-03-23
云南永安制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] There are not many methods for preparing the extract of Dilong Dilong, and the extract of Dilong Dilong obtained in the prior art has a low content of active ingredients and a serious waste of medicinal materials, and the extraction method needs to be improved

Method used

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  • Preparing method for fresh lumbricus extract
  • Preparing method for fresh lumbricus extract
  • Preparing method for fresh lumbricus extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Step 1, put 10kg of fresh earthworm into a bone crusher to break, and then put the fresh earthworm crushed by the bone crusher into a bone mud mill for beating;

[0048] Step 2, add 5% (w / w) sodium hydroxide solution of 5 times the weight to the fresh earthworm after beating, stir and let stand;

[0049] Step 3: Filtrate or centrifuge the extracted solution left standing in step 1 to obtain a supernatant;

[0050] Step 4, the clear liquid is concentrated into a clear paste with a relative density of 1.02 to 1.06 (25°C), and a mixed solution of ethanol and acetone with a concentration of 100% (v / v) (wherein the volume ratio of ethanol and acetone is 10:1) is added to make The alcohol content of the medicinal liquid is 55% (v / v), and it is left to stand after stirring until precipitation;

[0051] Step 5, filtering or centrifuging, removing the supernatant to obtain a precipitate, and drying the precipitate to obtain 500 g of the fresh earthworm extract of the present in...

Embodiment 2

[0053] Step 1, put 10kg of fresh earthworm into a bone crusher to break, and then put the fresh earthworm crushed by the bone crusher into a bone mud mill for beating;

[0054]Step 2, add 5% (w / w) sodium hydroxide solution of 5 times the weight to the fresh earthworm after beating, stir and let stand;

[0055] Step 3: Filtrate or centrifuge the extracted solution left standing in step 1 to obtain a supernatant;

[0056] Step 4, the clear liquid is concentrated into a clear paste with a relative density of 1.02 to 1.06 (25°C), and a mixed solution of ethanol and acetone with a concentration of 95% (v / v) (wherein the volume ratio of ethanol and acetone is 5:1) is added to make The alcohol content of the medicinal solution is 40% (v / v), and it is left to stand after stirring until precipitation;

[0057] Step 5, filtering or centrifuging, removing the supernatant to obtain a precipitate, and drying the precipitate to obtain 450 g of the fresh earthworm extract of the present inv...

Embodiment 3

[0059] Step 1, put 10kg of fresh earthworm into a bone crusher to break, and then put the fresh earthworm crushed by the bone crusher into a bone mud mill for beating;

[0060] Step 2, add 5% (w / w) sodium hydroxide solution of 5 times the weight to the fresh earthworm after beating, stir and let stand;

[0061] Step 3: Filtrate or centrifuge the extracted solution left standing in step 1 to obtain a supernatant;

[0062] Step 4, the supernatant is concentrated into a supernatant with a relative density of 1.02 to 1.06 (25° C.), and a mixed solution of ethanol and acetone with a concentration of 95% (v / v) (wherein the volume ratio of ethanol and acetone is 15:1) is added to make The alcohol content of the liquid medicine is 80% (v / v), and it is allowed to stand still after stirring, and to be precipitated;

[0063] Step 5, filtering or centrifuging, removing the supernatant to obtain a precipitate, and drying the precipitate to obtain 450 g of the fresh earthworm extract of th...

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Abstract

The invention relates to a preparing method for fresh lumbricus extract. The method comprises the following steps that 1, fresh lumbricus is thrown into a bone smashing machine to be smashed, and the fresh lumbricus smashed through the bone smashing machine is thrown into a bone paste mill to be mashed; 2, the mashed fresh lumbricus is added into an alkaline solution, and the mixture stands after being stirred; 3, an extracting solution after standing in the step 2 is filtered or centrifuged to obtain clear liquid; 4, the clear liquid is concentrated, an organic solution containing alcohol is added, the content of the alcohol in liquid medicine reaches 40-80% (v / v), and the liquid medicine stands after being stirred; 5, filtering or centrifuging is carried out to obtain precipitate, and the precipitate is dried to obtain the extract, wherein the organic solution containing the alcohol is selected from methyl alcohol, ethyl alcohol, propylene glycol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol and tertiary butanol, or a mixture of methyl alcohol, ethyl alcohol, propylene glycol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol and tertiary butanol, or a mixture of methyl alcohol, ethyl alcohol, propylene glycol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol and tertiary butanol and acetone.

Description

Technical field: [0001] The invention relates to a preparation of a traditional Chinese medicine extract, in particular to a preparation method of a fresh earthworm extract. Background technique: [0002] Earthworms are commonly known as Quzhi, and traditional Chinese medicine is called Dilong, which is cold in nature and salty in taste. Function: clearing away heat, calming liver, relieving asthma, dredging collaterals. Indications for high fever and mania, convulsions and convulsions, wind-heat headache, red eyes, hemiplegia, etc. [0003] In recent years, it has been found that earthworms contain lumbrokinase, which has a good therapeutic effect on cardiovascular diseases. Earthworm enzymes can not only activate fibrinolytic enzymes to dissolve thrombus, but also directly dissolve fibrin. The effective rate of clinical treatment of thrombosis is more than 80%. Earthworm enzyme also has the functions of reducing blood viscosity, inhibiting platelet aggregation, anticoag...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K47/10A61K47/08A61P7/02
CPCA61K9/0095A61K9/08A61K35/62A61K47/08A61K47/10
Inventor 李卫杰唐川唐富贵马关键赵军刘万水井利利张翠
Owner 云南永安制药有限公司
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