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A kind of two-layer oral repair film and its preparation method

A dual-function technology for oral restoration, applied in coating, medical science, surgery, etc., can solve the problem of poor mechanical properties and biodegradability of pure chitosan film, which cannot meet the multifunctional requirements of oral restoration film, and is not suitable for oral cavity Repair membrane materials and other problems, achieve good mechanical barrier effect, good biocompatibility, and improve biodegradability

Active Publication Date: 2018-07-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is used alone, it cannot meet the multifunctional requirements of oral restoration film, so it is often combined with other materials to achieve better performance (Taguchi Y, Amizuka N, Nakadate M, et al . A histological evaluation for guided bone regeneration induced by a collagenous membrane[J].Biomaterials, 2005, 26(31): 6158-6166.)
[0005] Chitosan, also known as deacetylated chitin, is a natural polymer with good biocompatibility and almost no antigenicity. It also has the functions of inducing tissue regeneration, hemostasis, antibacterial and antibacterial, etc. Medical materials, but the mechanical properties and biodegradability of pure chitosan film are poor, so it is not suitable for oral repair film materials, so people often modify chitosan or blend with other materials to improve its performance to achieve oral repair film Material requirements (PrabaharanM. Review paper: chitosan derivatives aspromising materials for controlled drug delivery[J]. JBiomaterAppl,2008,23(1):5-36.)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of the double-functional oral restoration membrane material comprises the following steps:

[0038] (1) Preparation of dense antibacterial layer:

[0039] ① dissolving oxidized chitosan in acetic acid solution to prepare 3g / L oxidized chitosan solution;

[0040] ②Dissolve type I collagen in 0.5M acetic acid solution, stir at 4°C to make 3g / L type I collagen solution;

[0041] ③Mix the solutions of step ① and ②, stir for 40 minutes, add ethanol to defoam, and then ultrasonically defoam, pour into the mold, and air-dry to form a film for later use;

[0042] ④ Immerse the film in the cross-linking solution for 8 hours and then air-dry it for later use;

[0043] (2) Preparation of loose porous layer:

[0044] (i) Dissolve type I collagen in dilute hydrochloric acid or acetic acid solution, stir at 4°C to dissolve it completely, and prepare a 3 g / L type I collagen solution;

[0045] (ii) Add oxidized chondroitin sulfate to the prepared type I colla...

Embodiment 2

[0055] The preparation method of the double-functional oral restoration membrane material comprises the following steps:

[0056] (1) Preparation of dense antibacterial layer:

[0057] ① dissolving oxidized chitosan in acetic acid solution to prepare 4g / L oxidized chitosan solution;

[0058] ②Dissolve type I collagen in 0.2M acetic acid solution, stir at 4°C to make 4g / L type I collagen solution;

[0059] ③Mix the solutions of step ① and ②, stir for 60 minutes, add ethanol to defoam, and then ultrasonically defoam, pour into the mold, and air-dry to form a film for later use;

[0060] ④ Immerse the film in the cross-linking solution and cross-link for 12 hours, then air-dry it for later use;

[0061] (2) Preparation of loose porous layer:

[0062] (i) Dissolve type I collagen in dilute hydrochloric acid or acetic acid solution, stir at 4°C to dissolve it completely, and prepare a 4g / L type I collagen solution;

[0063] (ii) Add oxidized hyaluronic acid to the prepared type...

Embodiment 3

[0073] The preparation method of the double-functional oral restoration membrane material comprises the following steps:

[0074] (1) Preparation of dense antibacterial layer:

[0075] ① dissolving oxidized chitosan in acetic acid solution to prepare 5g / L oxidized chitosan solution;

[0076] ②Dissolve type I collagen in 0.5M acetic acid solution, stir at 4°C to make 5g / L type I collagen solution;

[0077] ③Mix the solutions of step ① and ②, stir for 50 minutes, add ethanol to defoam, and after ultrasonic defoaming, pour into the mold, air-dry to form a film for later use;

[0078] ④ Immerse the film in the cross-linking solution for 10 hours and then air-dry it for later use;

[0079] (2) Preparation of loose porous layer:

[0080] (i) Dissolve type I collagen in dilute hydrochloric acid or acetic acid solution, stir at 4°C to dissolve it completely, and prepare a 5g / L type I collagen solution;

[0081] (ii) Add oxidized chondroitin sulfate to the prepared type I collagen ...

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PUM

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Abstract

The invention relates to a double-functional-layer oral restoration membrane and a preparation method thereof. The restoration membrane is formed by a loose porous layer and a dense antibacterial layer. The loose porous layer is formed by collagen I, oxidized polysaccharide and beta-tricalcium phosphate. The dense antibacterial layer is formed by compounding collagen I and oxidized chitosan. The restoration membrane has good mechanical performance, hydrophilia and biocompatibility, certain bacteria resistance and bacteriostasis performance and suitable and controllable degradation absorbability, preparation operation is easy, a good mechanical barrier effect is achieved, meanwhile, bonding of osteoblast and the membrane is facilitated, and Ca2+, P3- and the like are provided for formation of new teeth.

Description

technical field [0001] The invention relates to a double-functional oral cavity repair film and a preparation method thereof, belonging to the field of oral medical materials. Background technique [0002] In recent years, with the continuous development and progress of tissue engineering, a new repair technology—membrane guided bone regeneration (MGBR)—was born. The generation of MGBR has greatly improved the level of oral restorative science. [0003] Membrane for oral restoration is to place the membrane between oral soft tissue and bone defect by surgical operation to establish a biological barrier, so as to create a relatively closed environment for bone regeneration and selectively block fibroblasts and epithelial cells that migrate faster A biocompatible material that enters the bone defect area without hindering the natural healing of the wound. Dental repair films can be subdivided into: collagen film, metal film, synthetic film and allogeneic periosteum according ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/16
CPCA61L31/028A61L31/042A61L31/044A61L31/14A61L31/146A61L31/148A61L31/16A61L2300/232A61L2300/252A61L2300/404A61L2300/606A61L2430/12C08L89/00C08L5/08
Inventor 但年华薛媛但卫华刘婷
Owner SICHUAN UNIV