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Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material

A technology of mussel mucin and composite materials, applied in medical science, absorbent pads, bandages, etc., to achieve the effect of easy operation, soft texture and simple process

Inactive Publication Date: 2016-04-13
北京铂铱电气科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The hemostatic composite material using chitosan and marine mussel mucin and its preparation method have not been reported

Method used

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  • Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material
  • Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material
  • Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Weigh 0.2g of chitosan powder and dissolve it in 10ml of 0.1M dilute hydrochloric acid. After stirring for 0.5 hours, the obtained chitosan solution was sterilized under high temperature and high pressure at 121° C., cooled to room temperature, and used. Weigh 1.12g sodium β-glycerophosphate, add it into 2ml double distilled water, and dissolve to form a 56% sodium β-glycerophosphate solution. Filter through a 0.22 μm filter membrane and store in a 4°C refrigerator for later use. After the two solutions were ice-bathed for 15 minutes, the syringe sucked 9ml of the chitosan solution into a new beaker, stirred rapidly while adding 1ml of β-glycerophosphate sodium (β-GP) solution dropwise, and continued to stir. The homogeneously mixed product is placed in a constant temperature water bath at 37°C, and a milky white hydrogel can be formed within 5 minutes.

[0029] Cut chitosan hydrogel into 0.1cm 3 cubes were dehydrated in absolute ethanol for 5 min. The volume of ...

Embodiment 2

[0032] Weigh 0.3g of chitosan powder and dissolve it in 10ml of 0.1M dilute acetic acid. After stirring for 1 hour, add 1ml of mussel mucin solution of 10mg / ml to the chitosan solution, stir evenly, sterilize the obtained mixed solution at 121°C with high temperature and high pressure, cool to room temperature and use it. Weigh 1.2g of β-sodium glycerophosphate, add it into 2ml of double-distilled water, and dissolve to form a 60% sodium β-glycerophosphate solution. Filter through a 0.22 μm filter membrane and store in a 4°C refrigerator for later use. After the two solutions were ice-bathed for 15 minutes, the syringe sucked 7ml of the chitosan solution into a new beaker, stirred rapidly and added 1ml of the β-GP solution drop by drop, and continued to stir. The homogeneously mixed product is placed in a constant temperature water bath at 37°C, and a milky white hydrogel can be formed within 5 minutes.

[0033] Anesthetized adult rats were fixed for the test, and a 0.5 mm i...

Embodiment 3

[0034] Weigh 10 g of polyethylene glycol 5000 grafted chitosan (grafting rate 45%, chitosan viscosity average molecular weight 200,000) powder, and dissolve it in 100 ml of 0.1 M dilute hydrochloric acid. After stirring for 1 hour, a gel was formed after cooling and standing.

[0035] Cut chitosan hydrogel into 1cm 3 cubes were dehydrated in absolute ethanol for 5 min. The volume of the gel after partial dehydration is 1 / 2 of the original volume. Put the dehydrated gel into the mussel mucin solution with a concentration of 1 mg / ml, and when the gel absorbs water, the mussel mucin also enters the hydrogel system. The morphology and properties of the chitosan hydrogel system after reabsorbing water did not change compared with those before dehydration. The obtained finished product is the target product chitosan hydrogel and marine mussel mucin hemostatic composite material.

[0036] An anesthetized adult rat was fixed for the test, and a 0.5 mm incision was made on the caro...

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Abstract

The invention relates to a hemostasis composite material based on chitosan and marine mussel mucin and a specific preparation method of the hemostasis composite material. The hemostasis composite material comprises a chitosan type hydrogel carrier and the marine mussel mucin guided into the chitosan type hydrogel carrier. The hemostasis composite material is soft in texture, high in application performance, applicable to hemostasis of body-surface wounds and bleeding of parts such as internal tissue and organs, and excellent in hemostasis effect.

Description

technical field [0001] The invention relates to a biological hemostatic composite material, in particular to a hemostatic composite material based on chitosan and marine mussel mucin, and a specific preparation method thereof. Background technique [0002] Chitosan is a natural organic polymer polysaccharide derived from shrimp and crab shells. It is rich in sources and low in price. According to preliminary statistics, more than 2 billion tons of chitosan are extracted from organisms in the world every year. It can be said that chitosan is the inexhaustible and inexhaustible second largest natural biological organic resource next to cellulose in nature. . In terms of its function, natural chitosan has the properties of promoting tissue regeneration, antibacterial and antifungal growth. Chitosan's non-toxic, biodegradable, good compatibility with biological tissue, and the property of promoting wound healing endow it with good performance as a hemostatic material. It is s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44A61L15/42
Inventor 李舟王心心赵明王华英钱惜羽
Owner 北京铂铱电气科技有限公司
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