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Antibacterial and astringent Chinese herb toothpaste

A technology of Chinese herbal toothpaste and Chinese herbal medicine, applied in antibacterial drugs, dentistry, antipyretics, etc., can solve the problems of easily reducing the self-healing ability of various oral tissues, poor targeting of antibacterial active ingredients, and low content of active ingredients, so as to promote platelets The effect of adhesion and aggregation, shortening of plasma calcium coating time and thrombin time, and prolongation of shelf life

Active Publication Date: 2016-05-04
广州冰泉化妆品科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an antibacterial and hemostatic Chinese herbal medicine toothpaste to solve the problem that the existing traditional Chinese medicine toothpaste contains many traditional Chinese medicine prescriptions and complex composition, resulting in low content of active ingredients; the antibacterial active ingredients are poorly targeted, and long-term use can easily reduce the effect of various oral tissues on the toothpaste. Damage self-healing ability and other issues

Method used

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  • Antibacterial and astringent Chinese herb toothpaste
  • Antibacterial and astringent Chinese herb toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0042] Embodiment 4 in vitro antibacterial experiment

[0043] 1 Materials and methods

[0044] 1.1 Experimental bacteria: select 2 kinds of common oral pathogens: Streptococcus mutans (25175), Porphyromonas gingivalis (33277), Guangdong Microbial Culture Collection Center. Medium: BHI liquid medium, CDC anaerobic agar medium.

[0045] 1.2 Use the double dilution method to determine the minimum inhibitory concentration MIC and minimum bactericidal concentration MBC of the test sample against bacteria. Bacterial suspension preparation: Streptococcus mutans and Porphyromonas gingivalis were resuscitated for 48 hours, inoculated in BHI liquid medium, 37 ° C in 85% N 2 , 10%H 2 , 5%CO 2 After culturing in an anaerobic incubator for 24 hours under certain conditions, the bacterial growth reached the logarithmic phase at this time. After the smear microscopic examination showed pure culture, the bacterial liquid was collected and the bacterial concentration was adjusted to 1.0×1...

Embodiment 5

[0055] Example 5 In Vitro Hemostatic Experiment

[0056] 2 Materials and methods

[0057] 2.1 Preparation of anticoagulant blood: take blood from rabbit ear vein, and mix gently with 3.8% sodium citrate solution at a volume ratio of 9:1. Centrifuge the anticoagulated blood at 1000r / min for 10min to prepare platelet-rich plasma, and centrifuge at 3000r / min for 10min to prepare platelet-poor plasma.

[0058] 2.2 Preparation of sample solution

[0059] Chinese herbal medicine toothpaste samples 1-4, Yunnan Baiyao toothpaste liquid and Shuke toothpaste liquid of Examples 1-4 were prepared at 3.3 mg / mL.

[0060] 2.3 Determination of plasma calcium coverage time (RT)

[0061] Mix 0.1mL normal saline and 0.1mL platelet-rich plasma in a centrifuge tube, add 0.1mL CaCl with a mass fraction of 0.2775% in a water bath at 37°C 2 Mix the solution and start timing, and stop timing when a white filament is produced. The experiment was repeated 3 times and the average value was taken. R...

Embodiment 6

[0077] The clinical hemostasis experiment of embodiment 6 mice

[0078] 3 Materials and methods

[0079] 3.1 The hemostasis clinical experiment used blank paste, Yunnan Baiyao toothpaste, Shuke toothpaste, and Chinese herbal medicine toothpaste in Examples 1-4 as test samples.

[0080] 3.2 It is carried out by observing the hemostasis of local wound wounds in mice. Take 108 healthy Kunming mice, weighing 18-22 g, both male and female. After anesthetizing the mouse, use surgical scissors to cut off the left lobe of the liver with a length of about 0.5 cm, a width of about 0.5 cm, and a height of about 0.5 cm. After wiping off the sprayed blood, immediately apply 0.5 g of the sample to be tested on the face , oppressed with 200g weight for 1min, remove the weight after 1min, observe the hemostatic effect, until no bleeding. If bleeding still occurs, pressurize after applying the sample to be tested, observe once every 30s, and record the hemostatic time. If it does not exceed...

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Abstract

The invention discloses an antibacterial and astringent Chinese herb toothpaste, and belongs to the technical field of Chinese herb toothpaste preparation. The Chinese herb toothpaste is prepared from, by weight, 1%-4% of Chinese herbs, 64.8%-66.8% of auxiliaries and the balance deionized water, wherein the sum of the weight percents of the Chinese herbs, the auxiliaries and the deionized water is 100%. The Chinese herbs are composed of rhizoma bletillae, radix angelicae sinensis, radix astragali, ginkgo leaves and radix paeoniae rubra at the weight ratio of (3-7):(2-7):(2-5):(4-7):(5-8). The Chinese herb toothpaste has an antibacterial effect, further has the effects of stopping bleeding, diminishing inflammation, easing pain and the like and can achieve a good prevention effect on saprodontia, periodontitis, gum bleeding and other oral health problems when used for a long time.

Description

【Technical field】 [0001] The invention relates to a toothpaste for auxiliary treatment of oral inflammation, in particular to a Chinese herbal medicine toothpaste with antibacterial and hemostatic properties. 【Background technique】 [0002] Among oral diseases, periodontal disease and dental caries are common and frequently-occurring diseases in the human oral cavity, and the growth of oral bacteria is the main factor causing such diseases. Usually, by adding functional ingredients in the toothpaste, the toothpaste has the function of assisting in the prevention, prevention and alleviation of oral problems or has a certain improvement effect on the condition of the teeth. [0003] There are many factors that affect gum bleeding, and a large part of the reason is caused by inflammation caused by oral anaerobic bacteria. There are many types of bacteria in the oral cavity, the most important ones are Streptococcus and Bacteroides melanogenes, among which Streptococcus mutans ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q11/00A61P31/04A61P1/02A61P7/04A61P29/00
CPCA61K8/97A61K36/16A61K36/232A61K36/481A61K36/65A61K36/71A61K36/898A61K2800/28A61Q11/00A61K2300/00
Inventor 廖丹葵宋瑾林钻煌覃青云伍善广李玲许静杨卫豪黄光伟孙建华周利琴黄华来卢凯玲廖彭莹孙丽霞
Owner 广州冰泉化妆品科技有限公司
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