A kind of degradable light curing medical adhesive and its preparation and application
An adhesive, light-curing technology, used in applications, surgical adhesives, medical science, etc., can solve the problems of fast flushing, easy water absorption and swelling, cell damage, etc., and achieves convenient sizing and high bonding strength. , good bonding performance
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Embodiment 1
[0043] Preparation of PGS: Add 20.2574g (0.1mol) of sebacic acid (0.1mol) and 9.2037g (0.1mol) of glycerol after recrystallization and purification into a three-necked flask, melt at 135°C, and pass through N 2 Stir for 24h, then evacuate (4mbar) at 135°C for 48h, cool down to room temperature to give a pale yellow waxy solid.
[0044] 1 H NMR (400 MHz, Chloroform-d) δ 3.45-5.29 (m, 5H), 2.35 (m, 4H), 1.62 (m, 4H), 1.35 (m, 4H).
[0045] Synthesis of PGS-IM: The feeding of the reaction is carried out in a glove box (water content ≤ 0.1ppm, oxygen content ≤ 0.1ppm), weighing 1210.0mg (4.69mmol) PGS into a 25ml eggplant-shaped reaction bottle, and then adding 1.6ml without DMF in water, under nitrogen protection, placed in an 80°C oil bath and stirred until PGS was completely dissolved. 359.5 mg (2.35 mmol) of (2-isocyanoethyl)methacrylate were added and the reaction was complete after 20 minutes. Precipitate with deionized water to remove DMF, then dissolve with tetrahydrofu...
Embodiment 2
[0054] Preparation of PGS: Add 20.2574g (0.1mol) of sebacic acid (0.1mol) and 9.2037g (0.1mol) of glycerol after recrystallization and purification into a three-necked flask, melt at 135°C, and pass through N 2 Stir for 24h, then evacuate (4mbar) at 135°C for 48h, cool down to room temperature to give a pale yellow waxy solid.
[0055] Synthesis of PGS-IM: The feeding of the reaction is carried out in a glove box (water content ≤ 0.1ppm, oxygen content ≤ 0.1ppm), weighing 4.69mmol) PGS is added to a 25ml eggplant type reaction bottle, and then 1.6ml anhydrous DMF is added, Under nitrogen protection, place in an 80°C oil bath and stir until the PGS is completely dissolved. Add 4 mmol (2-isocyanoethyl) methacrylate, and the reaction ends after 20 minutes. Precipitate with deionized water to remove DMF, then dissolve with tetrahydrofuran, and precipitate with deionized water three times to remove unreacted (2-isocyanoethyl) methacrylate monomer to obtain a white viscous semi-sol...
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