Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Thermocured electrospun egg-white protein micro-nanofiber membrane and preparation method therefor

A technology of micro-nano fiber and egg white protein, which is applied in the field of heat-cured electrospun egg white protein micro-nano fiber membrane and its preparation, can solve the problems of stimulating skin allergic reaction, corrosive and irritating, harmful to human body and environment, and achieves Good biocompatibility and degradability, simple preparation method, and the effect of reducing production costs

Active Publication Date: 2016-05-11
QINGDAO UNIV
View PDF7 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, collagen, chitosan, polylactic acid, polycaprolactone, but due to the limitations of the material itself, their application is limited
Chinese patent (application number: CN200610116988.3) discloses a preparation method of collagen and chitosan composite nanofibers and membrane electrospinning, which realizes the bionic and implantation of natural extracellular matrix composed of polysaccharides and high molecular proteins The drug sustained release system in the body, but the hexafluoroisopropanol solvent used in the preparation is corrosive and irritating, and has a pungent smell. If you use it for a long time, you will feel dizzy
Chinese patent (application number: CN201210355709.4) discloses a method for preparing nanofibers by electrostatic spinning of collagen aqueous solution, and obtains attractive collagen nanofibers. Unfortunately, it is necessary to add acid to adjust the pH value 2-4, directly used on the skin, it will cause irritation and cause skin allergic reaction
Chinese patent (application number CN201410560021.9) discloses a two-step cross-linking method for preparing keratin / polyethylene oxide PEO bio-nanofiber membranes, which effectively realizes the regeneration and utilization of waste keratin fibers, but this method prepares spinning The organic solvent used in the solution is highly irritating and harmful to the human body and the environment, which limits its application in the biomedical field, and the organic solvent used will also increase production costs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thermocured electrospun egg-white protein micro-nanofiber membrane and preparation method therefor
  • Thermocured electrospun egg-white protein micro-nanofiber membrane and preparation method therefor
  • Thermocured electrospun egg-white protein micro-nanofiber membrane and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing a heat-cured electrospun egg white protein micro-nano fiber membrane, comprising the following steps:

[0031] (1) Configure the spinning precursor solution: add 0.15 grams of polyethylene oxide (PEO, AldrichChemistry) in the Erlenmeyer flask, then add 5 grams of deionized water, stir with a magnetic stirrer, and stir for 1 hour at room temperature to make Polyethylene oxide is fully dissolved and prepared as solution A. Add 5 grams of fresh egg white into the conical flask containing the prepared solution A, stir with a magnetic stirrer to fully dissolve solution A and egg white, and prepare the spinning precursor liquid;

[0032] (2) Electrospun fiber: Inhale the prepared precursor solution into a 5 ml syringe and fix it on the propulsion pump 1. The flow of the spinning precursor solution is controlled by the propulsion pump 1, and the propulsion pump is turned on. The propulsion rate of the propulsion pump is 0.7 milliliters / hour; Link to eac...

Embodiment 2

[0034] A method for preparing a heat-cured electrospun egg white protein micro-nano fiber membrane, comprising the following steps:

[0035] (1) Add 0.075 grams of polyethylene oxide (PEO, AldrichChemistry) to the Erlenmeyer flask, then add 5 grams of fresh egg white, and stir with a magnetic stirrer to fully dissolve the PEO in the egg white, and prepare it as a spinning precursor liquid;

[0036] (2) Inhale the prepared precursor solution into a 5 ml syringe and fix it on the propulsion pump 1. The flow of the spinning precursor solution is controlled by the propulsion pump 1, and the propulsion pump is turned on. The propulsion rate of the propulsion pump is 0.7 ml / hour Link to each other with spinning nozzle 5 by conduit, spinning nozzle 5 internal diameters are 0.34 millimeters, open high-voltage power supply 2 and heat blower 6 and carry out electrospinning, spinning nozzle 5 is 20 centimetres to the distance of collection cylinder 4, spinning voltage 16 thousand volts,...

Embodiment 3

[0038] A method for preparing a heat-cured electrospun egg white protein micro-nano fiber membrane, comprising the following steps:

[0039] (1) Configure the spinning precursor solution: add 1.3 grams of polyvinylpyrrolidone (PVP, BODI) in the Erlenmeyer flask, then add 5 grams of deionized water, stir with a magnetic stirrer, and stir for 2 hours at room temperature to make PVP is fully dissolved and prepared into solution A. Add 5 grams of fresh egg white to the conical flask equipped with prepared solution A, and stir with a magnetic stirrer to fully mix solution A and egg white to prepare a spinning precursor;

[0040] (2) Electrospun fiber: Inhale the prepared precursor solution into a 5 ml syringe and fix it on the propulsion pump 1. The flow of the spinning precursor solution is controlled by the propulsion pump 1, and the propulsion pump is turned on. The propulsion rate of the propulsion pump is 0.8 milliliters / hour; Link to each other with spinning nozzle 5 by condu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a thermocured electrospun egg-white protein micro-nanofiber membrane and a preparation method therefor. The micro-nanofiber membrane is prepared with an electrostatic spinning method; an organic solvent is not added in a preparation process; a micro-nanofiber forming the micro-nanofiber membrane is an egg-white protein / water-soluble macromolecular polymer composite fiber; and egg-white protein is thermal denatured and cured protein. The micro-nanofiber membrane has very high biocompatibility and degradability; the egg-white protein micro-nanofiber membrane has very good wettability, easily permeates the skin, is easily absorbed by the skin and is pure natural without side effects; the preparation method is simple; in the preparation process, natural egg white and a water-soluble macromolecular polymer are taken as raw materials and the organic solvent does not need to be extra added, so that the production cost is reduced and the environment is friendly; and therefore, the preparation method is suitable for large-scale production.

Description

technical field [0001] The invention relates to a heat-cured electrospun egg white protein micro-nano fiber membrane and a preparation method thereof, belonging to the field of nano-material preparation. Background technique [0002] With the improvement of living standards, people's awareness and demand for healthy life are becoming stronger and stronger, especially natural biological materials are favored by more and more people. As we all know, egg white contains such as: iron that can enhance hematopoietic function; vitamin b2 that can maintain the normal renewal of epithelial cells with vigorous metabolism; niacin that can prevent skin roughness and thickening caused by solar dermatitis; can effectively promote hair regeneration , pantothenic acid that can eliminate fine wrinkles; sterols that can maintain the moisture on the skin surface and promote skin metabolism, and have the functions of hair growth, black hair and external application of burn treatment. As a heal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): D04H1/728D01F8/02D01D5/00
CPCD01D5/0007D01D5/003D01F8/02D04H1/728
Inventor 龙云泽王乐张丽华贾宪生闫旭何宏伟冯吉勇郭家
Owner QINGDAO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products