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Allyl isothiocyanate double-layer micro-capsule sustained release agent taking chitosan as carrier, and preparation method thereof

A technology of horseradish and sustained-release agent, which is applied in the field of horseradish double-layer microcapsule sustained-release agent and its preparation, can solve the problems of reducing drug burst release and short sustained-release effect, so as to improve the safety of use and extend the Long-lasting effect and short reaction time

Active Publication Date: 2016-05-25
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional single-layer microcapsule sustained-release agents are prone to burst release problems, and the sustained-release effect is relatively short, while double-layer microcapsule sustained-release agents have a longer sustained-release time and can effectively reduce drug burst release.

Method used

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  • Allyl isothiocyanate double-layer micro-capsule sustained release agent taking chitosan as carrier, and preparation method thereof
  • Allyl isothiocyanate double-layer micro-capsule sustained release agent taking chitosan as carrier, and preparation method thereof
  • Allyl isothiocyanate double-layer micro-capsule sustained release agent taking chitosan as carrier, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Preparation method

[0038] 1) Preparation of horseradish single-layer microcapsule sustained-release agent: 10.0g horseradish, 1.5g toluene-2,4-diisocyanate, 6.0g emulsifier (phenylethylphenol polyoxyethylene polyoxypropylene ether 4.0 g, calcium dodecylbenzenesulfonate 2.0g) fully mix and stir, then add 20.0g aqueous acetic acid containing 2% chitosan, adopt 6000 rpm high-speed shear emulsifier to shear and stir emulsification for 4min, drop Add two drops of polydimethylsiloxane for defoaming, change the speed to 600 rpm and continue stirring for 1 hour to obtain chitosan monolayer microcapsules of horseradish;

[0039] 2) Preparation of horseradish double-layer microcapsules: Slowly add 20 g of an aqueous solution with a content of 2% sodium alginate to the horseradish single-layer microcapsule slow-release agent prepared above, continue stirring for 40 minutes, and then slowly drop 4g of 2% calcium chloride aqueous solution, fully stirred evenly, added 38.5g of ...

Embodiment 2

[0045] 1. Preparation method

[0046] 1) Preparation of horseradish single-layer microcapsule sustained release agent: 20.0g horseradish, 5.0g toluene-2,6-diisocyanate, 10.0g emulsifier (castor oil polyoxyethylene ether) were fully mixed and stirred evenly, Then add 25.0 g of sulfuric acid aqueous solution containing 2% chitosan, use 8000 rpm high-speed shear emulsifier to shear and stir emulsification for 3 minutes, add two drops of polypropylene glycol, and change it to 400 rpm and stir for 1 hour to obtain Chitosan monolayer microcapsules of horseradish.

[0047] 2) Preparation of horseradish double-layer microcapsules: Slowly add 10 g of an aqueous solution of 2% sodium alginate to the single-layer microcapsules prepared above, continue stirring for 40 minutes, and slowly add 2 g of 2% calcium chloride aqueous solution dropwise , fully stir evenly, add 28g content and be 1% gum arabic aqueous solution and stir evenly, adjust the pH value to 6.8 with a few drops of 10% sod...

Embodiment 3

[0053] 1. Preparation method

[0054] 1) Preparation of horseradish single-layer microcapsule sustained-release agent: 30.0g horseradish, 8.0g toluene-2,4-diisocyanate, 2.0g toluene-2,6-diisocyanate, 10.0g emulsifier (ricin Sesame oil polyoxyethylene ether 8.0g, sodium dodecylbenzene sulfonate 2.0g) fully mix and stir, then add 15.0g phosphoric acid aqueous solution containing 2% chitosan, adopt 10000 rev / min high-speed shear emulsifying machine to shear Cut, stir and emulsify for 5 minutes, add two drops of polypropylene glycol dropwise, change the speed to 400 rpm and stir for 1 hour to obtain chitosan monolayer microcapsules of horseradish.

[0055] 2) Preparation of horseradish double-layer microcapsules: Slowly add 10 g of an aqueous solution of 2% sodium alginate to the above-prepared horseradish single-layer microcapsules, continue stirring for 40 minutes, and then slowly add 3 g of 2% chlorine Calcium chloride aqueous solution, fully stirred evenly, added 22 g of 0.5%...

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Abstract

The invention provides an allyl isothiocyanate double-layer micro-capsule sustained release agent taking chitosan as a carrier, and a preparation method thereof. According to the allyl isothiocyanate double-layer micro-capsule sustained release agent, allyl isothiocyanate is taken as the capsule core; an interfacial polymerization product of toluene diisocynate and chitosan is taken as a first layer capsule wall carrier material; and an alginic acid membrane layer is taken as a second layer capsule wall carrier layer. Reaction process of the preparation method of the allyl isothiocyanate double-layer micro-capsule sustained release agent is short; a double-layer capsule wall is formed at normal temperature; release speed can be controlled; volatilization and decomposition loss of allyl isothiocyanate are prevented effectively; product stability is improved; the allyl isothiocyanate double-layer micro-capsule sustained release agent is high in storage stability, and is safe, sustained release can be realized, and development and application prospect is promising.

Description

technical field [0001] The invention belongs to the field of novel pesticide preparations, and in particular relates to a horseradish double-layer microcapsule slow-release agent with chitosan as a carrier and a preparation method thereof. Background technique [0002] The main component of horseradish is allyl isothiocyanate (AITC), which is a colorless to pale yellow transparent oily liquid with volatility. The main uses of allyl isothiocyanate include: food flavoring agent, food sterilization and antibacterial, antiseptic preservative; health care and anticancer drugs; soil sterilization and deworming, warehouse deworming and anticorrosion, building fumigation, fumigation of plant quarantine treatment Agents; chemical synthesis intermediates, etc., are widely used in food, chemical, pesticide and pharmaceutical industries. Although horseradish has broad-spectrum bactericidal and insecticidal activities, it has strong volatility and high inhalation toxicity, and it is eas...

Claims

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Application Information

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IPC IPC(8): A01N47/46A01N25/28A01P3/00A01P7/04
Inventor 曹永松丁光龙段永恒郭明程张文兵郭栋王佰涛张兆鹏李健强
Owner CHINA AGRI UNIV
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