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Active targeting blood fat lowering drug with nanocarbon crystals as carrier and preparation method thereof

A blood lipid-lowering drug and nano-carbon crystal technology, which is applied in drug combinations, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., can solve problems such as abnormal liver enzymes, non-universal and systematic treatment, and increased drug cycle , to achieve the effect of reducing blood lipid and arteriosclerosis, increasing target recognition rate, and eliminating arteriosclerosis

Inactive Publication Date: 2016-05-25
ZHENGZHOU ARTIFICIAL DIAMOND & PROD ENG TECH RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although traditional statins can treat hyperlipidemia to a certain extent, they also have some drug side effects: because statins are passive targeted drugs, patients need to use drugs for a long time or in large doses, resulting in potential liver enzyme abnormalities and muscle toxicity; at the same time, the treatment of hyperlipidemia often involves personal eating habits, and most patients do not pay enough attention to it—they still consume high-protein, high-calorie and high-fat foods during the period of medication, which weakens the efficacy of the drug and increases the cycle of medication
Traditional Chinese medicine formulas and compositions mainly start from the conditioning of the human body. Although they can effectively treat various types of arteriosclerosis and have a certain function of preventing recurrence, they all need to prepare different pharmaceutical formulas for different causes, and there is no universal and systematic treatment. the role of

Method used

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  • Active targeting blood fat lowering drug with nanocarbon crystals as carrier and preparation method thereof
  • Active targeting blood fat lowering drug with nanocarbon crystals as carrier and preparation method thereof
  • Active targeting blood fat lowering drug with nanocarbon crystals as carrier and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The preparation of embodiment 1 nanometer carbon crystal

[0030] Nano carbon crystal among the present invention adopts following method to prepare, and step is:

[0031] (1) Preliminary crushing: firstly, the diamond raw material is sent into the crushing cavity of the mechanical crusher, and is crushed by the high-speed rotating hammer head inside the crusher. The material stays in the crusher for re-crushing, and the granular material filtered by the finest screen in the lower layer of the crusher is collected by the sieve plate (the mesh number of the screen is not less than 32 mesh), while the material filtered by other mesh screens can be used as Coarse materials are sold or used to prepare materials with other particle sizes; particles above 32 mesh are used for primary particle size separation by a multi-layer vibrating sieve machine. The vibrating sieve time is generally controlled at 30min~3h, and the mesh number of the sieve is sequentially arranged from 40 ...

Embodiment 2

[0039] An active targeted blood lipid-lowering drug based on nano-carbon crystals, its structure is as follows: figure 1 As shown, carbon nanocrystals are used as a carrier, and galactosamine (hepatocyte active targeting factor) and rosuvastatin are loaded on the carrier. The preparation method and properties of carbon nanocrystals refer to Example 1.

[0040] The above-mentioned active targeted blood lipid-lowering drug using nano-carbon crystals as a carrier is prepared by the following method, the steps are:

[0041] (1) Load galactosamine (hepatocyte active targeting factor) on carbon nanocrystals: ① Mix nanocarbon crystals and galactosamine aqueous solution at a mass ratio of 0.04︰1, and ultrasonically emulsify for 10 minutes to obtain an emulsion. The power is 150W;

[0042] ②Wash the emulsion with deionized water through dilution until the pH is 7~7.5, and centrifuge;

[0043] ③ Take the precipitate and dry it by centrifuging at a low temperature at 10°C to obtain nan...

Embodiment 3

[0049] An active targeting blood lipid-lowering drug using nano-carbon crystals as a carrier, using surface-functionalized nano-carbon crystals as a carrier, loaded with galactosamine (hepatocyte active targeting factor) and rosuvastatin, The preparation method and properties of nanocarbon crystals refer to Example 1.

[0050] The above-mentioned active targeting blood lipid-lowering drug with surface-functionalized nano-carbon crystals as a carrier is prepared by the following method, and the steps are as follows:

[0051] (1) Use the strong acid oxidation method to functionalize the surface of nano-carbon crystals. The treatment process is as follows:

[0052] ① Put the nano-carbon crystals in concentrated HNO with a mass ratio of 1:3 3 / Concentrated H 2 SO 4 In the mixed solution, heat and reflux at 90°C for 50 hours and then centrifuge to precipitate; take the precipitate and wash it with deionized water until the pH of the washing solution is 4.0~5.0;

[0053] ② Use ...

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Abstract

The invention discloses an active targeting blood fat lowering drug with nanocarbon crystals as a carrier and belongs to the field of cardiovascular drugs. The nanocarbon crystals serve as the carrier, and galactosamine and statin drugs are supported on the carrier. The invention further discloses a preparation method of the active targeting blood fat lowering drug. The preparation method includes the steps that galactosamine is supported on the nanocarbon crystals, and the statin drugs are supported on the nanocarbon crystals supported with galactosamine. According to the active targeting blood fat lowering drug with the nanocarbon crystals as the carrier, the nanocarbon crystals serve as the carrier, one kind of the statin drugs can be carried, the active targeting blood fat lowering drug can reach a focus in an active targeting mode under the effect of hepatic cell active targeting factor galactosamine, and finally achieves the effect of lowering blood fat and eliminating arteriosclerosis.

Description

technical field [0001] The invention belongs to the field of cardiovascular drugs, and in particular relates to an active targeting blood lipid-lowering drug using nano-carbon crystals as a carrier and a preparation method thereof. Background technique [0002] In modern society, there are many kinds of diets, and all kinds of fried and high-fat foods are full of people's daily life, which leads to the average blood lipid content of the human body higher than the previous level, and various indicators such as cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein The phenomenon of increased height is particularly common. This phenomenon has spread from middle-aged and elderly people to young people, and it has become more and more obvious among children in developed areas. It is easy to cause diseases such as coronary heart disease, stroke, and loss of organ function, resulting in vision loss, kidney disease, etc. Functional failure, limb necrosis a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K47/26A61K31/505A61P3/06
CPCA61K9/143A61K9/145A61K31/505
Inventor 郭留希赵清国何本锋武艳强刘君丽刘永奇杨晋中张建华邵静茹穆小娜
Owner ZHENGZHOU ARTIFICIAL DIAMOND & PROD ENG TECH RES CENT
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