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Probiotic fermentation blood replenishing composition and preparation method and application thereof

A probiotics and composition technology, applied in the directions of bacteria, applications, and drug combinations used in food preparation, can solve the problems of insufficient iron supplementation, gastrointestinal irritation, and blackened teeth in patients, and improve human nutrition. the effect of anemia

Inactive Publication Date: 2016-06-01
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pure traditional Chinese medicine blood-enriching preparations mainly promote the absorption of iron in the diet by improving the functions of the human spleen and stomach. At the same time, they can also promote the hematopoietic function of bone marrow cells, and then nourish blood by nourishing blood. However, the simple iron preparations have quick onset and definite curative effect, but iron preparations generally have the defects of being irritating to the gastrointestinal tract, and the taste is poor, and the teeth will be stained black; although the existing traditional Chinese medicine iron preparations are better than In the above two cases, there are still side effects such as diarrhea and loss of appetite, so patients often stop treatment because of intolerable gastrointestinal side effects

Method used

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  • Probiotic fermentation blood replenishing composition and preparation method and application thereof
  • Probiotic fermentation blood replenishing composition and preparation method and application thereof
  • Probiotic fermentation blood replenishing composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation of Probiotic Fermented Blood Enrichment Composition A

[0022] Take Chinese medicine jujube 100g, medlar 100g, mulberry 200g, longan meat 100g, add water to soak for 2.0 hours, decoct twice, the first time for 2.0 hours, the second time for 1.0 hours, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to About 1000ml, the relative density measured at 50°C is 1.03; crush 40g donkey-hide gelatin, melt (add appropriate amount of the above-mentioned Chinese medicine concentrate to dissolve completely), mix with the above-mentioned Chinese medicine concentrate, add ferrous gluconate 0.088g, zinc sulfate 0.044g, 0.24mg of sodium selenite, adjust the pH to 7.0, and sterilize at 115°C for 50 minutes. ) and 0.5% by volume of Lactobacillus acidophilus (AS1.1854), Lactobacillus plantarum (AS1.19) and Lactobacillus delbrueckii (AS1.1480), fermented at 37°C for 16-28 hours The pH value is detected, and when the pH value drops be...

Embodiment 2

[0023] Example 2: Preparation of Probiotic Fermented Blood Enrichment Composition B

[0024] Take 200g of traditional Chinese medicine jujube, 120g of medlar, 120g of mulberry, and 60g of longan meat, soak in water for 1.0 hour, decoct twice, the first time for 2.0 hours, the second time for 2.0 hours, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to About 1000ml, the relative density measured at 50°C is 1.04; crush 20g of donkey-hide gelatin, melt (add appropriate amount of the above-mentioned Chinese medicine concentrate to dissolve completely), mix with the above-mentioned Chinese medicine concentrate, add 0.44g of sodium ferric edetate , zinc gluconate 0.22g, selenoprotein (containing 3000PPM selenium) 50mg, adjust the pH to 6.5, and sterilize at 110°C for 60 minutes, when the temperature drops to 37°C, at the same time inoculate about 1.0% of pre-cultured volume percentage Animal Bifidobacterium (CGMCC1.3003) and Bifidobacterium bifidum...

Embodiment 3

[0025] Example 3: Preparation of Probiotic Fermented Blood Enrichment Composition C

[0026] Take 300g of jujube, 50g of medlar, 50g of mulberry, and 40g of longan meat, soak in water for 1.0 hour, decoct twice, the first time for 1.0 hour, the second time for 1.0 hour, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to About 1000ml, the relative density measured at 50°C is 1.02; crush 60g of donkey-hide gelatin, melt (add an appropriate amount of the above-mentioned Chinese medicine concentrate to dissolve it completely), mix it with the above-mentioned Chinese medicine concentrate, add 0.90g of ferrous fumarate, lactic acid Zinc (containing 3 crystalline water) 0.26g, selenium-enriched yeast (2000PPM selenium) 150mg, adjusted to pH 7.5, and sterilized at 121°C for 30 minutes. 1.0% of Bifidobacterium adolescentis (CGMCC1.2190) bacteria solution, then inoculated with pre-cultured Lactobacillus fermentum (CGMCC1.3269) and Lactobacillus delbruec...

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Abstract

The invention discloses a probiotic fermentation blood replenishing composition and a preparation method thereof. The method includes the steps of conducting water soaking, extracting and concentrating on traditional Chinese medicines Chinese dates, fructus lycii, mulberries and arillus longan, adding donkey-hide gelatin molten by heat, adding trace elements, adjusting the pH value, conducting sterilizing, and inoculating multiple strains of probiotics for fermentation to prepare the probiotic fermentation blood replenishing composition. It is shown through the test result that the probiotic fermentation blood replenishing composition can remarkably improve the content of hemoglobin of tested patients, free erythrocyte protoporphyrin in red blood cells of tested patients is remarkably reduced, the content of serum ferritin is remarkably improved, and the function of remarkably improving body alimentary anemia and the effect of remarkably promoting growth of main probiotics in human intestines in vitro are achieved.

Description

technical field [0001] The invention relates to a composition and a preparation method thereof, in particular to a probiotic fermented blood enriching composition and a preparation method thereof, belonging to the technical field of biological fermentation. Background technique [0002] Anemia refers to a common clinical symptom in which the volume of red blood cells in the peripheral blood of the human body decreases, which is lower than the lower limit of the normal range. Nutritional anemia is a small cell hypochromic anemia caused by decreased hemoglobin synthesis caused by iron deficiency in the body. Clinically, it is characterized by decreased serum iron concentration, transferrin saturation and serum ferritin, and is characterized by effective iron treatment. Symptoms include pale complexion or chlorosis, light lip and nail color, fatigue, loss of appetite, etc. About 10-30% of the population in the world suffers from iron deficiency in varying degrees. [0003] Th...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P7/06A61P1/00A23L33/00A23L33/105A23L33/135A61K33/04A61K33/26A61K33/30A61K35/745A61K35/747A61K35/36
CPCA61K33/04A61K33/26A61K33/30A61K35/36A61K35/745A61K35/747A61K36/605A61K36/725A61K36/77A61K36/815A61K2236/19A61K2236/331A61K2236/39A23V2002/00A23V2400/137A23V2400/145A23V2400/147A23V2400/143A23V2400/151A23V2400/181A23V2400/125A23V2400/513A23V2400/515A23V2400/517A23V2400/519A23V2400/175A23V2400/529A23V2400/113A23V2400/533A23V2400/169A61K2300/00A23V2200/30A23V2200/3204A23V2250/21A23V2250/204
Inventor 吴炳新褚新红孙筱林甄宗武吕美
Owner SANZHU FUER PHARMA
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