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Cefquinome sulfate muscle injection and preparation method thereof

A cefquinome sulfate and injection technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of inability to maintain antibacterial concentration for a long time, poor redispersibility, and low drug content and other problems, to achieve the effect of fine particle size, slow sedimentation and stable preparation content

Inactive Publication Date: 2016-06-08
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cefquinome sulfate has been registered in my country, but the existing cefquinome sulfate intramuscular injection suspension has high viscosity, poor redispersibility, poor needle penetration, difficult injection, low drug content, poor absorption in the body, and cannot maintain effectiveness for a long time antibacterial concentration

Method used

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  • Cefquinome sulfate muscle injection and preparation method thereof
  • Cefquinome sulfate muscle injection and preparation method thereof
  • Cefquinome sulfate muscle injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031] The oily vehicle is prepared by mixing soybean oil and medium-chain triglycerides at a volume ratio of 1:3.

[0032] Preparation:

[0033] (1) Add stearin, polyoxyethylene hydrogenated castor oil, and 2,4-di-tert-butyl-4-methylphenol into the oily solvent successively, stir and heat up to 50°C to melt the suspending agent and antioxidant , cooled to 30°C;

[0034] (2) Add the cefquinome sulfate sterile powder into (1), and stir evenly;

[0035] (3) Transfer the mixture in (2) to a high-speed shear disperser for grinding and dispersing, set the rotation speed at 8000rpm, and the time for 15min;

[0036] (4) Fill the prepared pre-preparation in a 50mL glass bottle, carry out cobalt-60 ray irradiation sterilization, and the irradiation dose is 6KGY, to obtain cefquinome sulfate intramuscular injection.

Embodiment 2

[0038]

[0039] The oily medium is prepared by mixing soybean oil and medium-chain triglycerides in a volume ratio of 1:2.

[0040] Preparation:

[0041] (1) Add stearin, polyoxyethylene hydrogenated castor oil, and 2,4-di-tert-butyl-4-methylphenol into the oily solvent successively, stir and heat up to 50°C to melt the suspending agent and antioxidant , cooled to 30°C;

[0042] (2) Add the cefquinome sulfate sterile powder into (1), and stir evenly;

[0043] (3) Transfer the mixture in (2) to a high-speed shear disperser for grinding and dispersing, set the rotation speed at 8000rpm, and the time for 15min;

[0044] (4) Fill the prepared pre-preparation in a 50mL glass bottle, carry out cobalt-60 ray irradiation sterilization, and the irradiation dose is 6KGY, to obtain cefquinome sulfate intramuscular injection.

Embodiment 3

[0046]

[0047] The oily vehicle is prepared by mixing soybean oil and medium-chain triglycerides in a volume ratio of 3:1.

[0048] Preparation:

[0049] (1) Add stearin, polyoxyethylene hydrogenated castor oil, and 2,4-di-tert-butyl-4-methylphenol into the oily solvent successively, stir and heat up to 50°C to melt the suspending agent and antioxidant , cooled to 30°C;

[0050] (2) Add the cefquinome sulfate sterile powder into (1), and stir evenly;

[0051] (3) Transfer the mixture in (2) to a high-speed shear disperser for grinding and dispersing, set the rotation speed at 8000rpm, and the time for 15min;

[0052] (4) Fill the prepared pre-preparation in a 50mL glass bottle, carry out cobalt-60 ray irradiation sterilization, and the irradiation dose is 6KGY, to obtain cefquinome sulfate intramuscular injection.

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Abstract

The invention discloses a cefquinome sulfate muscle injection and a preparation method of the cefquinome sulfate muscle injection. The cefquinome sulfate muscle injection is prepared from cefquinome sulfate, a suspending agent, a wetting agent, an antioxidant and an oily solvent. The preparation method is characterized by preparing a suspension of which the color is similar to white and is sandy beige through grinding of a high-speed shear dispersion instrument, and sterilizing the cefquinome sulfate muscle injection by adopting an irradiation sterilization technology. The cefquinome sulfate muscle injection prepared by the invention has the advantages of good physical and chemical stability, fine granularity, slow sedimentation, good redispersibility, good needling performance, stable content, simplicity and feasibility in preparation technology and capability of being beneficial for industrial large-scale production; after the cefquinome sulfate muscle injection is injected intramuscularly, the release is slow, the elimination half life is long, the effect is durable, and the bioavailability is high.

Description

technical field [0001] The invention relates to a cefquinome sulfate intramuscular injection and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] In recent years, my country's breeding industry has continued to grow and develop, bringing huge economic benefits to farmers. At the same time, various bacterial infectious diseases are still one of the main diseases that endanger poultry and livestock, with rapid onset and high mortality, causing serious economic losses for farmers. Antibiotics are commonly used antibacterial drugs, but due to the abuse of antibiotics, drug resistance is gradually increasing, and the efficacy of antibacterial drugs is significantly reduced. Therefore, the field of veterinary medicine urgently needs a new, high-efficiency animal-specific antibacterial drug. [0003] Cefquinome, also known as cefquinol or cefquinome, is a newly discovered fourth-generation cephalosporin a...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/44A61K47/14A61K31/546A61P31/04
CPCA61K9/10A61K9/0019A61K31/546A61K47/14A61K47/44
Inventor 柯学张强王悦王剑萍
Owner CHINA PHARM UNIV
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