Biological type nerve conduit

Abstract

The invention discloses a biological type nerve conduit.The biological type nerve conduit comprises a fiber-felt inner layer composed of regenerated silk fibroin fibers mixed with vascular endothelial growth factors and alkaline fibroblast growth factors and having three-dimensional staggered network structure characteristics, wherein the outer surface of the fiber-felt inner layer is sequentially covered with a porous transition layer, an anticoagulation layer and an outer layer, a plurality of cavities for storing a bioactive factor solution is formed in the fiber-felt inner layer and are located between the outer surface of the fiber-felt inner layer and the inner surface of the porous transition layer, and the outer layer is a hydrophobic-fiber-felt outer layer composed of regenerated silk fibroin fibers mixed with copper ions and having three-dimensional staggered network structure characteristics.The biological type nerve conduit provides a three-dimensional space for neural recovery, it is ensured that the nerve conduit has appropriate strength, hardness and elasticity, bioactive factors can be loaded in a required mode before an operation, the product production quality can be easy to control, the survival rate of the bioactive factors can be greatly improved, and neural regeneration is more efficiently promoted.

Description

technical field [0001] The invention relates to the field of biomedical materials and implantable medical devices, in particular to a biological nerve guide. Background technique [0002] The nervous system is one of the most important organs in the human body, which controls the sensory and motor functions of the human body. Various traumas such as compression, stretching, tearing, cutting, and other factors such as ischemia, tumors, etc. will cause partial or complete damage to the nervous system, resulting in loss of function and other neurological diseases. The repair and functional reconstruction of defective nerves is one of the difficult problems to be overcome by human beings. The neuronal axons of peripheral nerves can extend under appropriate conditions and grow longer than the injured area to achieve the purpose of nerve regeneration. With the help of neurosurgery, especially the development of microneurosurgery, the repair and regeneration of nerve injury has b...

AI Technical Summary

Problems solved by technology

[0009] (3) The materials used must have low cytotoxicity, mild local tissue adverse reactions, etc.;

Images