Application of PCL-PEG-PCL tri-block copolymer in preparation of medical anti-blocking material

A technology of C500-E1000-C500 and C500-E2000-C500, which is applied in the field of PCL-PEG-PCL triblock copolymers in the preparation of medical anti-adhesion materials, can solve the problems of unfavorable human safety, non-biodegradable, short residence time, etc. problems, to achieve outstanding comprehensive performance, rapid biodegradation, and good biocompatibility

Active Publication Date: 2010-09-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the high critical gel concentration of poloxamer (Pluronic or Poloxamer, PEG-PPG-PEG), which is the main component of the material, the gel strength is weak, the residence time of the gel state in the body is too short, and it cannot be biodegraded , easy to accumulate in the body and other shortcomings, so this material is difficult to be widely used in this field
[0005] At present, other medical anti-adhesion materials that can be used either need to be dissolved in organic solvents, which is not conducive to human safety; or the anti-adhesion effect is not good, and the price is expensive, making it difficult to prepare, transport and store

Method used

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  • Application of PCL-PEG-PCL tri-block copolymer in preparation of medical anti-blocking material
  • Application of PCL-PEG-PCL tri-block copolymer in preparation of medical anti-blocking material
  • Application of PCL-PEG-PCL tri-block copolymer in preparation of medical anti-blocking material

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Synthesis and verification of embodiment 1 PCL-PEG-PCL copolymer

[0041] 1) Synthesis of PCL-PEG-PCL copolymer

[0042] The brief synthetic route of PCL-PEG-PCL copolymer of the present invention is as follows Figure 4 shown.

[0043] according to figure 1 The synthesis route of the method is to add a certain amount of polyethylene glycol (PEG) and ε-caprolactone (ε-CL) in a three-necked flask equipped with a stirrer, and use stannous octoate as a catalyst, at 120-180 ° C, nitrogen The product is obtained after reacting for 3-24 hours under protected conditions, cooled to room temperature for purification, and dried.

[0044] According to the method described above, C 500 -E 1000 -C 500 、C 500 -E 2000 -C 500 、C 1000 -E 2000 -C 1000 、C 500 -E 1540 -C 500 、C 700 -E 1000 -C 700 、C 800 -E 1000 -C 800 、C 1000 -E 1000 -C 1000 、C 1000 -E 1500 -C 1000 、C 1500 -E 1500 -C 1500 and C 1000 -E 600 -C 1000 and other series of copolymers (see Table 1...

Embodiment 2

[0052] Embodiment 2 uses PCL-PEG-PCL copolymer to prepare medical anti-adhesion material

[0053] The PCL-PEG-PCL triblock copolymer prepared by using the above-mentioned embodiment is prepared into a medical anti-adhesion material. Because each PCL-PEG-PCL three-block copolymer is made into the method principle of hydrogel is identical, and condition is very similar, so the present invention mainly cites C 800 -E 1000 -C 800 as an example.

[0054] The preparation process of the medical anti-adhesion material of the present invention is: first the C 800 -E 1000 -C 800 The copolymer is dissolved in physiological saline at a concentration of 5-40wt%, preferably at a concentration of 8-25wt%, fully stirred and mixed uniformly. The mixed physiological saline solution was heated and stirred at 50-60°C for about 5 minutes to form a translucent viscous liquid, which was cooled to below 4°C for use. There are two methods of use: 1: inject the anti-adhesion hydrosol around the ...

Embodiment 3

[0055] Embodiment 3 Anti-adhesion effect experiment of medical anti-adhesion material of the present invention

[0056] In this example, the hydrogel is used as an anti-adhesion barrier to investigate its effect on postoperative adhesion.

[0057] The specific method is to first dissolve the copolymer prepared in Example 2 in physiological saline to prepare a 15wt% solution, then refrigerate the sol-like hydrogel for more than 24 hours at below 4°C, and through crystallization, the water coagulates After the gel has finished gelling, when applying, directly spread the gel evenly around the wound in the abdominal cavity.

[0058] 1. Abdominal wall-cecum friction injury model: anesthetize the animal, open the abdomen, rub the cecum with dry gauze, damage the surface serosa layer, and peel off the serosa layer with a scalpel on the adjacent abdominal wall (mouse: 1×1cm ; rat: 2×2 cm). Then apply PCL-PEG-PCL hydrogel (mice: 0.2ml; rats: 1ml) on the injured surface evenly, and cl...

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Abstract

The invention relates to the field of medicinal macromolecular materials, in particular to the application of a tri-block copolymer in the preparation of a medical anti-blocking material, aiming to provide a new choice for using the medical anti-blocking material in the field. A technical scheme of the invention is to provide the application of the polycaprolactone-polyethyleneglycol- polycaprolactone (PCL-PEG-PCL) tri-block copolymer in the preparation of the medical anti-blocking material, wherein the PCL-PEG-PCL copolymer has a molecular weight ranging from 1,500 to 8,000, the ratio of themolecular weight of the PEG chain segment to that of the PCL chain segment ranges from 0.2 to 2.5. The copolymer can be dissolved in water to form a solution and can form when a certain concentrationis achieved. Experiments show that the hydrogel of the PCL-PEG-PCL block copolymer can effectively prevent post-operation adhesion, thereby the invention provides a new choice for this field.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to the use of a PCL-PEG-PCL triblock copolymer in preparing medical anti-adhesion materials. Background technique [0002] Postoperative adhesions are common clinical problems after abdominal, gynecological, and cardiac surgery, and are the main cause of postoperative complications such as intestinal obstruction, infertility, and pain. For example, adhesive intestinal obstruction accounted for 60% of intestinal obstruction in the United States in 2004, especially postoperative adhesive intestinal obstruction after pelvic surgery such as obstetrics and gynecology, appendectomy, and colorectal surgery. In recent years, it has become a new trend in the world to prevent postoperative adhesions by implanting isolation materials in the parts prone to postoperative adhesions. However, since postoperative adhesion is a problem that has not been solved for a long time in the field o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61K47/34A61P41/00A61L31/06
Inventor 钱志勇魏于全赵霞巩长旸
Owner SICHUAN UNIV
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