Porous bone scaffold manufacturing device and method

Abstract

The invention discloses a porous bone scaffold manufacturing device and method. The method comprises a three-dimensional movement framework structure, an extruding unit, an extruding mechanism, a working surface and a temperature control unit mounted on the working surface, wherein the extruding unit comprises a liquid storage device and a linear unit; the extruding mechanism comprises a fixing clamp for fixing the extruding unit, a push rod for pushing a bone material in the liquid storage device to be extruded, and a driving mechanism for driving the push rod to do reciprocating motion; the extruding unit does the reciprocating motion in X-axis and Y-axis directions in the three-dimensional movement framework structure; the working surface does the reciprocating motion in a Z-axis direction in the three-dimensional movement framework structure. The porous bone scaffold manufacturing device disclosed by the invention is simple in structure, convenient to operate and low in manufacturing cost; a solution can be stably extruded; porous bone scaffold structures of different pore diameters, different pore structures, different sizes and different strip shapes can be manufactured through extruding high-viscosity biological ink.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a porous bone support manufacturing device and manufacturing method. Background technique [0002] The repair of bone defects caused by various traumas, bone tumors, osteonecrosis and other reasons has always been a thorny issue in the field of orthopedics. At present, in the face of existing traditional bone defect treatment methods including autologous bone grafting and autologous cancellous bone grafting, although autologous bone grafting provides good osteoconduction, osteoinduction, and osteogenesis, there are insufficient donors and expensive operations. The cycle is long and other problems, and the allograft bone transplantation is very likely to cause rejection, and the treatment effect is poor. [0003] The use of bone tissue engineering technology to prepare artificial bone scaffolds to replace bone defects is a hot topic in the field of regenerative medicin...

AI Technical Summary

Problems solved by technology

The above methods all have different defects, such as the low efficiency of the scaffold manufactured by electrospinning technology, and the mechanical properties of the manufactured scaffold are low; the intercommunication of the porous scaffold pore structure produced by the pore-forming agent method is not good, and the pore size is not uniform; The size of the pores inside the porous scaffold manufactured by the foam replication method is uncontrollable, and there is also the disadvantage that the pore structure is not interconnected; the particle precipitation method has the disadvantages of the internal pore size of the scaffold being too small, the size is uncontrollable, and the pores are irregular; the laser sintering method has the disadvantages of equipment The input cost is high, and the powder requirements for manufacturing bone scaffolds are high.

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