Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for treating metronidazole wastewater

A treatment method and technology for metronidazole, which are applied in the field of treatment of metronidazole wastewater, can solve the problems of high pollution, polluted environment, and the ineffective recycling of various useful substances, so as to reduce pollution, protect the environment, and reduce labor. effect of time

Active Publication Date: 2016-07-20
HUBEI HONGYUAN PHARMA
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the problem that the waste water produced in the existing metronidazole production process contains many kinds of highly polluting organic matter and salts, direct discharge will pollute the environment, and many useful substances have not been effectively recycled and utilized, and provides a kind of formazan The treatment method of nidazole wastewater recovers and reduces the sodium sulfate, sodium formate and ethylene glycol present in the metronidazole wastewater, significantly reduces the content of polluting organic matter and inorganic salts in the metronidazole wastewater, and finally makes each ton of formazan Nitazole wastewater was reduced from 15 tons to about 1 ton

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Take 2000 grams of metronidazole secondary centrifugation mother liquor, control the temperature at -5°C, crystallize for 6 hours, and centrifuge to obtain 520 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is distilled under reduced pressure, concentrated to remove 280 grams of water ; Mother liquor A was temperature controlled at 5°C, crystallized for 6 hours, centrifuged to obtain 16 grams of wet metronidazole, refined, and dried to 6 grams; mother liquor B was added 40 grams of concentrated sulfuric acid; stirred, temperature controlled at 5°C, crystallized for 6 hours, centrifuged to obtain 2 -Methyl-5-nitroimidazole 20g wet product, refined and dried to 8g; mother liquid C was heated to 40°C, slowly added 100g hydrogen peroxide solution, and reacted for 8h; the obtained reaction liquid was cooled to -5°C , 120 grams of sodium sulfate decahydrate crystals were precipitated; the obtained residual mother l...

Embodiment 2

[0044] Take 2000 grams of the metronidazole secondary centrifugation mother liquor, control the temperature at 5° C., crystallize for 12 hours, and centrifuge to obtain 508 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is distilled under reduced pressure, concentrated to remove 500 grams of water; Control the temperature of mother liquor A at 25°C, crystallize for 36 hours, centrifuge to obtain 17 grams of wet metronidazole, refine it, and dry it to 6.5 grams; add 100 grams of concentrated sulfuric acid to mother liquor B; stir, control the temperature at 25°C, crystallize for 36 hours, and centrifuge to obtain 2- 22 grams of methyl-5-nitroimidazole wet product, refined and dried to 9 grams; the mother liquid C was heated to 40 ° C, slowly added 160 grams of hydrogen peroxide solution, and reacted for 12 hours; the obtained reaction solution was cooled to 5 ° C, and precipitated 110 grams of sodium sulfate decahyd...

Embodiment 3

[0046] Take 2000 grams of metronidazole secondary centrifugation mother liquor, control the temperature at 0°C, crystallize for 9 hours, and centrifuge to obtain 529 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is concentrated to remove 400 grams of water by distillation under reduced pressure; Control the temperature of mother liquor A at 15°C, crystallize for 21 hours, centrifuge to obtain 18 grams of wet metronidazole, refine it, and dry it to 7 grams; add 70 grams of concentrated sulfuric acid to mother liquor B; stir, control the temperature at 15°C, crystallize for 21 hours, and centrifuge to obtain 2- 23 grams of methyl-5-nitroimidazole wet product, refined and dried to 9 grams; the mother liquid C was heated to 65 ° C, slowly added 130 grams of hydrogen peroxide solution, and reacted for 8 hours; the obtained reaction solution was cooled to 0 ° C, and precipitated 130 grams of sodium sulfate decahydrate c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of industrial wastewater treatment and recycling, and relates to a method for treating metronidazole wastewater. The method comprises the steps of pretreating and recycling salts and organic matters in metronidazole production wastewater, so that the content of polluting organic matters and inorganic salts in the metronidazole wastewater is reduced, and finally, the wastewater amount in every tonnage of metronidazole is reduced from the original 15 tons to about 1 tons.

Description

technical field [0001] The invention relates to a method for treating metronidazole wastewater, which belongs to the technical field of industrial wastewater treatment and recovery. Background technique [0002] Metronidazole is a relatively cheap antibiotic raw material in the pharmaceutical industry. It mainly adopts chemical methods such as cyclization, oxidation, nitration, and addition to make various chemical raw materials undergo multi-step complex chemical reactions to produce the required pharmaceutical intermediates. Body and synthetic raw materials. In the production process of metronidazole, many processes are currently using 2-methyl-5-nitroimidazole as a raw material. Under the condition of formic acid and sulfuric acid as solvents, it undergoes an addition reaction with ethylene oxide. And and separated to obtain the finished metronidazole. In this process, the required raw materials for producing one ton of metronidazole are: 1.22 tons of formic acid, 1.15 ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C02F9/10C07D233/94C07D233/92C07C31/20C07C29/80C01D5/00C02F101/38C02F101/34
CPCC01D5/00C02F1/04C02F9/00C02F2101/34C02F2101/38C02F2301/08C07C29/80C07C31/202C07D233/92C07D233/94
Inventor 方耀徐双喜晏浩哲方高童武丰光俊
Owner HUBEI HONGYUAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com