Method for treating metronidazole wastewater

A treatment method and technology for metronidazole, which are applied in the field of treatment of metronidazole wastewater, can solve the problems of high pollution, polluted environment, and the ineffective recycling of various useful substances, so as to reduce pollution, protect the environment, and reduce labor. effect of time

Active Publication Date: 2016-07-20
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims at the problem that the waste water produced in the existing metronidazole production process contains many kinds of highly polluting organic matter and salts, direct discharge will pollute the environment, and many useful substances have not been effectively recycled and utilized, and provides a kind of formazan The treatment method of nidazole wastewater recovers and reduces the sodium sulfate, sodium formate and ethylene glycol present in the metronidazole wastewater, significantly reduces the content of polluting organic matter and inorganic salts in the metronidazole wastewater, and finally makes each ton of formazan Nitazole wastewater was reduced from 15 tons to about 1 ton

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Take 2000 grams of metronidazole secondary centrifugation mother liquor, control the temperature at -5°C, crystallize for 6 hours, and centrifuge to obtain 520 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is distilled under reduced pressure, concentrated to remove 280 grams of water ; Mother liquor A was temperature controlled at 5°C, crystallized for 6 hours, centrifuged to obtain 16 grams of wet metronidazole, refined, and dried to 6 grams; mother liquor B was added 40 grams of concentrated sulfuric acid; stirred, temperature controlled at 5°C, crystallized for 6 hours, centrifuged to obtain 2 -Methyl-5-nitroimidazole 20g wet product, refined and dried to 8g; mother liquid C was heated to 40°C, slowly added 100g hydrogen peroxide solution, and reacted for 8h; the obtained reaction liquid was cooled to -5°C , 120 grams of sodium sulfate decahydrate crystals were precipitated; the obtained residual mother l...

Embodiment 2

[0044] Take 2000 grams of the metronidazole secondary centrifugation mother liquor, control the temperature at 5° C., crystallize for 12 hours, and centrifuge to obtain 508 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is distilled under reduced pressure, concentrated to remove 500 grams of water; Control the temperature of mother liquor A at 25°C, crystallize for 36 hours, centrifuge to obtain 17 grams of wet metronidazole, refine it, and dry it to 6.5 grams; add 100 grams of concentrated sulfuric acid to mother liquor B; stir, control the temperature at 25°C, crystallize for 36 hours, and centrifuge to obtain 2- 22 grams of methyl-5-nitroimidazole wet product, refined and dried to 9 grams; the mother liquid C was heated to 40 ° C, slowly added 160 grams of hydrogen peroxide solution, and reacted for 12 hours; the obtained reaction solution was cooled to 5 ° C, and precipitated 110 grams of sodium sulfate decahyd...

Embodiment 3

[0046] Take 2000 grams of metronidazole secondary centrifugation mother liquor, control the temperature at 0°C, crystallize for 9 hours, and centrifuge to obtain 529 grams of sodium sulfate decahydrate crystals and a small amount of metronidazole; the obtained mother liquor A is concentrated to remove 400 grams of water by distillation under reduced pressure; Control the temperature of mother liquor A at 15°C, crystallize for 21 hours, centrifuge to obtain 18 grams of wet metronidazole, refine it, and dry it to 7 grams; add 70 grams of concentrated sulfuric acid to mother liquor B; stir, control the temperature at 15°C, crystallize for 21 hours, and centrifuge to obtain 2- 23 grams of methyl-5-nitroimidazole wet product, refined and dried to 9 grams; the mother liquid C was heated to 65 ° C, slowly added 130 grams of hydrogen peroxide solution, and reacted for 8 hours; the obtained reaction solution was cooled to 0 ° C, and precipitated 130 grams of sodium sulfate decahydrate c...

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PUM

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Abstract

The invention belongs to the technical field of industrial wastewater treatment and recycling, and relates to a method for treating metronidazole wastewater. The method comprises the steps of pretreating and recycling salts and organic matters in metronidazole production wastewater, so that the content of polluting organic matters and inorganic salts in the metronidazole wastewater is reduced, and finally, the wastewater amount in every tonnage of metronidazole is reduced from the original 15 tons to about 1 tons.

Description

technical field [0001] The invention relates to a method for treating metronidazole wastewater, which belongs to the technical field of industrial wastewater treatment and recovery. Background technique [0002] Metronidazole is a relatively cheap antibiotic raw material in the pharmaceutical industry. It mainly adopts chemical methods such as cyclization, oxidation, nitration, and addition to make various chemical raw materials undergo multi-step complex chemical reactions to produce the required pharmaceutical intermediates. Body and synthetic raw materials. In the production process of metronidazole, many processes are currently using 2-methyl-5-nitroimidazole as a raw material. Under the condition of formic acid and sulfuric acid as solvents, it undergoes an addition reaction with ethylene oxide. And and separated to obtain the finished metronidazole. In this process, the required raw materials for producing one ton of metronidazole are: 1.22 tons of formic acid, 1.15 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F9/10C07D233/94C07D233/92C07C31/20C07C29/80C01D5/00C02F101/38C02F101/34
CPCC01D5/00C02F1/04C02F9/00C02F2101/34C02F2101/38C02F2301/08C07C29/80C07C31/202C07D233/92C07D233/94
Inventor 方耀徐双喜晏浩哲方高童武丰光俊
Owner HUBEI HONGYUAN PHARMA
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