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Skin dressing and preparation method of skin dressing

A skin-to-skin contact technology, which is applied in medical science, absorbent pads, bandages, etc., can solve the problem that the speed of drug release cannot meet the requirements, and achieve the effects of accelerated release, directional induction and repair, and convenient use

Active Publication Date: 2016-07-27
致成医疗科技(湖北)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the speed of its drug release is still not up to the requirement

Method used

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  • Skin dressing and preparation method of skin dressing
  • Skin dressing and preparation method of skin dressing
  • Skin dressing and preparation method of skin dressing

Examples

Experimental program
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Effect test

preparation example Construction

[0049] The preparation method of skin dressing comprises doping method and suction filtration method, and wherein doping method comprises the following steps:

[0050] (1) Soak the bacterial cellulose film with a thickness of 3 mm to 14 mm in the solution or suspension of the conductive material, so that the conductive material penetrates into the surface of the bacterial cellulose film at 1 mm to 3 mm, and the conductive material in the surface is The content of the material is 5mg / cm 2 ~50mg / cm 2 ;

[0051] (2) cutting the bacterial cellulose film in a direction parallel to the surface, and by controlling the thickness of the cut, a composite hydrogel film of 2 mm to 7 mm can be obtained;

[0052] (3) Soak the composite hydrogel film in a drug solution with a concentration of 2 μg / ml to 20 μg / ml for 12 hours to 48 hours, so that the surface of the composite hydrogel film absorbs 2 μg / cm 2 ~20μg / cm 2 The drug is used to obtain the skin dressing; the drug is one or more of...

Embodiment 1

[0065] Utilize Acetobacter glucosus ATCC53582, inoculate in S-H medium (medium composition: 1L water contains 20 grams of glucose, 5 grams of yeast powder, 5 grams of peptone, 1.5 grams of citric acid, 2.7 grams of disodium hydrogen phosphate). Static culture at 26° C. for 15 days to obtain a bacterial cellulose hydrogel hydrogel with a thickness of about 10 mm to 12 mm. Soak bacterial cellulose hydrogel in distilled water for two days, then boil in 1wt% sodium hydroxide solution for 30 minutes, take it out and wash it with distilled water until neutral to obtain pure bacterial cellulose hydrogel. Save for later.

[0066] (1) The bacterial cellulose hydrogel was soaked in a 20% ammonium persulfate solution and allowed to stand for 24 hours. Take it out, rinse the surface with distilled water three times, then soak the bacterial cellulose hydrogel in a solution of pyrrole monomer and ethanol mixed at a volume of 1:10, and let it stand for 0.5 hours. Obtain the bacterial cellu...

Embodiment 2

[0071] Repeat Example 1 with the same steps as described, except that the pyrrole monomer is replaced by aniline monomer.

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Abstract

The invention discloses a skin dressing and a preparation method of the skin dressing. The skin dressing takes bacterial cellulose as a base and has a skin contact surface and a conductive surface, wherein the electric conductivity of the skin contact surface is smaller than 10<-5>S / cm and the skin contact surface contains 2Mug / cm<2> to 20Mug / cm<2> of drugs; the conductive surface contains 5mg / cm<2> to 50mg / cm<2> of a conductive material, and the conductive material is one or more of a conductive macromolecular material and a conductive nano material; the skin contact surface is used for being in direct contact with a skin so as to heal a wound of the skin; the conductive surface is used for loading voltage so as to control the releasing speed of the drugs on the skin contact surface, and is also used for simulating a biological endogenous electrical field and indirectly accelerating the healing of the wound. According to the skin dressing disclosed by the invention, the conductive surface is in tight combination with the skin contact surface, so that the endogenous electrical field of the wound of the skin can be simulated very well and the skin dressing is more convenient to use.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a skin dressing and a preparation method thereof. Background technique [0002] Skin dressings are used to protect and cover wounds after trauma. Modern skin dressings can not only resist mechanical stimuli, resist pollution and chemical stimuli, prevent secondary infection, prevent dryness and body fluid loss, but also debride wounds, simulate biological endogenous electric fields to induce skin repair, and actively affect the wound healing process , Create a microenvironment that promotes wound healing. [0003] For example, patent document CN103205863A discloses a preparation method of bacterial cellulose sustained-release dressing. The polymer nanofibers with drug sustained-release function were obtained, and the original three-dimensional nano-network structure of bacterial cellulose was maintained. However, the speed of its drug release is still not up...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/42
CPCA61L15/28A61L15/42A61L15/44A61L2300/402A61L2300/404A61L2300/414A61L2300/418A61L2300/426C08L1/02
Inventor 杨光石志军蔡欣宇廖雅文周学思刘佳彤张海祥
Owner 致成医疗科技(湖北)有限公司