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Detection method for urocanic acid and ethyl urocanate in cosmetics on the basis of ion mobility spectrometry

An ion mobility spectrometry and detection method technology, which is applied in the field of cosmetic quality and safety detection, can solve the problems of reducing the immunity of living organisms, skin allergic and inflammatory reactions, etc., and achieves the effects of simple method, high sensitivity and shortened analysis time.

Active Publication Date: 2016-08-10
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urocanic acid and its ethyl ester, as an ultraviolet absorber, can play a certain role in skin protection, but it will reduce the immunity of living organisms and cause skin allergic and inflammatory reactions

Method used

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  • Detection method for urocanic acid and ethyl urocanate in cosmetics on the basis of ion mobility spectrometry
  • Detection method for urocanic acid and ethyl urocanate in cosmetics on the basis of ion mobility spectrometry
  • Detection method for urocanic acid and ethyl urocanate in cosmetics on the basis of ion mobility spectrometry

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Experimental program
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Embodiment 1

[0052] 1. Instruments and reagents:

[0053] GA 2100 ion mobility spectrometer; ACQUITY liquid chromatograph, Xevo TQ MS tandem quadrupole mass spectrometer, MassLynx data processing system; Milli-Q ultrapure water device; analytical balance.

[0054] Unless otherwise specified, the reagents used are of analytical grade, and the water is the first-grade water specified in GB / T 6682.

[0055] Methanol: chromatographically pure; formic acid: chromatographically pure; acetonitrile: chromatographically pure; tetrahydrofuran; sodium chloride; urocanic acid standard; urocanic acid ethyl ester standard.

[0056] 2. Preparation of standard solution

[0057] Accurately weigh 10 mg of urocanic acid and its ethyl ester respectively, place them in 10 mL volumetric flasks, prepare a standard stock solution with a concentration of 1000 mg / L with methanol solution, and then pipette the standard stock solution of urocanic acid and its ethyl ester Each 1mL in a 10mL volumetric flask, diluted...

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Abstract

The invention discloses a rapid detection method for urocanic acid and ethyl urocanate in cosmetics on the basis of ion mobility spectrometry (IMS). The method employs the IMS for analysis and a sample is directly injected in an electro-spray ionization manner. Analysis conditions are described as follows: the ionization mode is a positive ion mode; the ion source temperature is 180 DEG C; electro-spray pressure is 2487V for urocanic acid and 3505V for ethyl urocanate; gas preheating temperature is 180 DEG C; voltage of a mobility tube is 8000 V; temperature of the mobility tube is 180 DEG C; mobility spectral width is 26 ms; ionic mobility gas flow velocity is 1.0 l / min, and suction speed of a gas discharge pump is 0.42 l / min. The detection method has short detection period and high analytic speed, and achieves on-site rapid detection for quality safety of products.

Description

technical field [0001] The invention relates to the field of cosmetic quality and safety testing, in particular to a detection method for urocanic acid and its ethyl ester in cosmetics based on ion mobility spectrometry. Background technique [0002] In recent years, with the continuous development of the cosmetics industry, sunscreen cosmetics are widely favored by consumers because of their ability to protect the human body from ultraviolet radiation damage. The use of substances to ensure the safety of cosmetics has also become a matter of great concern. [0003] One of the functional additives in sunscreen cosmetic formulations is UV absorbers, which provide sun protection. As an ultraviolet absorber, urocanic acid and its ethyl ester can play a certain role in skin protection, but it will reduce the immunity of living organisms and cause skin allergic and inflammatory reactions. In my country's "Safety and Technical Specifications for Cosmetics" and "EU 1223 / 2009 Cosm...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N1/28G01N30/02G01N30/06G01N27/623
CPCG01N1/28G01N27/622G01N30/02G01N30/06
Inventor 马强郭项雨白桦孟宪双
Owner CHINESE ACAD OF INSPECTION & QUARANTINE