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Preparation method for inorganic microspheres, inorganic microspheres prepared thereby, and application of inorganic microspheres

A microsphere, inorganic technology, applied in inorganic chemistry, chemical instruments and methods, medical science and other directions, can solve the problems of large diameter distribution of microspheres, inability to obtain inorganic microspheres, and low proportion of inorganic components, and achieve reproducibility. The effect of good performance, avoid deterioration and simple preparation process

Active Publication Date: 2016-08-17
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the problem with magnesium phosphate cement is that the curing process is exothermic and releases ammonia
[0005] There have been reports on how to prepare inorganic powders into microspheres, such as the preparation of hydroxyapatite microspheres, but the proportion of inorganic components in this method is small, and complete inorganic microspheres cannot be obtained after burning off the organic components at high temperature
In addition, the spray drying method is also used to prepare ammonium metatungstate microspheres. This method requires special equipment, and the diameter of the microspheres has a large distribution range.

Method used

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  • Preparation method for inorganic microspheres, inorganic microspheres prepared thereby, and application of inorganic microspheres
  • Preparation method for inorganic microspheres, inorganic microspheres prepared thereby, and application of inorganic microspheres
  • Preparation method for inorganic microspheres, inorganic microspheres prepared thereby, and application of inorganic microspheres

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preparation example Construction

[0045] The present invention provides a preparation method of inorganic microspheres and the inorganic microspheres prepared therefrom and its use. The inorganic components of the obtained inorganic microspheres have a high proportion, and after burning off the organic components at high temperature, complete inorganic microspheres can be obtained. , and inorganic microspheres of various diameter ranges can be obtained. The preparation process of the invention is simple, and the microspheres can be formed directly through sintering, which can prevent the moisture-sensitive powder from deteriorating when forming the microspheres.

[0046] In order to better understand the above-mentioned technical solution, the above-mentioned technical solution will be described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0047] In the preparation method of the inorganic microspheres in the embodiment of the present application, gelatin ...

Embodiment 1

[0067] Prepare a gelatin solution with a mass fraction of 15%; add 250mL simethicone oil to a 500mL beaker and place it in a -20°C refrigerator for pre-cooling; install a mechanical stirrer. Take a 5mL centrifuge tube, add 0.2g amorphous calcium phosphate, add 1024μL deionized water, stir well; add 226μL gelatin solution, stir well, inhale into a 1mL syringe in a 70°C water bath, and put the syringe in a 70°C water bath to keep warm . Take out the pre-cooled simethicone beaker and place it under the mechanical stirrer. The mechanical stirring rod goes deep into the bottom of the beaker to raise the temperature of the simethicone to -4°C and start stirring at 280rpm. Take out the syringe, slowly drop into simethicone, stir for about 3 minutes, and let it stand for 1 hour. Remove the simethicone, wash it twice with acetone, add a glutaraldehyde solution with a mass fraction of 2.5%, and after 3 hours, remove the glutaraldehyde solution, wash it twice with absolute ethanol, and ...

Embodiment 2

[0070] Prepare a gelatin solution with a mass fraction of 15%; add 250mL benzyl silicone oil to a 500mL beaker and place it in a -20°C refrigerator for pre-cooling; install a mechanical stirrer. Take a 5mL centrifuge tube, add 874μL deionized water to 0.2g amorphous calcium phosphate, stir well; add 150μL polyvinyl alcohol solution (containing 0.02g polyvinyl alcohol), stir well; add 226μL gelatin solution, stir well, in Inhale into a 1mL syringe in a water bath at 80°C, and place the syringe in a water bath at 80°C to keep warm. Take out the pre-cooled simethicone beaker and place it under the mechanical stirrer. The mechanical stirring rod goes deep into the bottom of the beaker to raise the temperature of the simethicone to 1°C and start stirring at 250rpm. Take out the syringe, slowly drop into simethicone, stir for about 3 minutes, and let it stand for 1 hour. Remove the simethicone, wash it twice with acetone, add a glutaraldehyde solution with a mass fraction of 2.5%, ...

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Abstract

The invention relates to a preparation method for inorganic microspheres, the inorganic microspheres prepared by the preparation method, and an application of the inorganic microspheres. The preparation method for the inorganic microspheres comprises the following steps: with gelatin as a microsphere template, controlling a sphere-shaping temperature and a sphere diameter, preparing inorganic powder into inorganic / gelatin composite microspheres, then carrying out sintering, and removing the gelatin so as to obtain the inorganic microspheres. The preparation method provided by the invention has simple preparation process and good reproducibility, and can obtain the inorganic microspheres with a variety of diameter ranges; the method directly prepares the microspheres through sintering, can prevent the powder sensitive to water from deterioration during formation of the microspheres, and is especially applicable to preparation of the inorganic microspheres sensitive to water (like alpha-tricalcium phosphate and magnesium oxide); meanwhile, the prepared inorganic microspheres have potential application values in the field of injectable bone cement.

Description

technical field [0001] The invention relates to the technical field of inorganic materials, in particular to a method for preparing inorganic microspheres, the inorganic microspheres prepared therefrom and applications thereof. Background technique [0002] In recent years, because injectable bone cement is especially suitable for the repair of bone defects with small operating space or narrow gap, it has received extensive attention. Among them, calcium phosphate and magnesium phosphate injectable bone cements have been practically used. [0003] As an important component of calcium phosphate bone cement, α-tricalcium phosphate has been used in the field of bone repair; it is characterized by its hydration properties, which can form a chemical formula of Ca when combined with water 9 (HPO 4 )(PO 4 ) 5 (OH) 5 calcium phosphate salt; and bone cement is mainly prepared in powder state. In general, the finer the powder, the higher the activity of α-tricalcium phosphate, b...

Claims

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Application Information

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IPC IPC(8): C01B25/32C01F5/06A61L27/12A61L27/02A61L27/50A61L27/58
CPCA61L27/02A61L27/12A61L27/50A61L27/58C01B25/321C01F5/06C01P2004/03C01P2004/60
Inventor 谭生龙罗政强
Owner ASIA BIOMATERIALS WUHAN CO LTD
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