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Medicine composition of buspirone hydrochloride and medical application thereof

A technology of buspirone hydrochloride and a composition, applied in the field of biomedicine, can solve the problems of arthritis, synovial membrane invading knee articular cartilage, and no reports related to buspirone hydrochloride synovitis, etc. The effect of improving the effect and highlighting the substantive characteristics

Inactive Publication Date: 2016-08-17
周飞燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The morphological changes of the synovium will also invade the cartilage of the knee joint. If not treated in time, it will lead to osteoarthritis of the knee joint, and there is a great risk of disability
[0004] So far, there has been no report on the correlation between buspirone hydrochloride and its pharmaceutical composition and synovitis

Method used

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  • Medicine composition of buspirone hydrochloride and medical application thereof
  • Medicine composition of buspirone hydrochloride and medical application thereof
  • Medicine composition of buspirone hydrochloride and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Separation method: (a) Grind the dry rhizome (2kg) of Anemarrhena anemarrhena, extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In step (a), the ethyl acetate extract was removed with D101 type macroporous resin, first eluted with 25% ethanol for 8 column volumes, then with 70% ethanol for 12 column volumes, and collected 70% eluate, Concentrate under reduced pressure to obtain a 70% ethanol elution concentrate; (c) in step (b), the 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45: The dichloromethane-methanol gradien...

Embodiment 2

[0026] Embodiment 2: pharmacological action

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029] Male Wistar rats (provided by the Animal Experiment Center of Tongji Medical College, Huazhong University of Science and Technology) with a body weight of about 120 g were selected.

[0030] 1.2 Reagents and samples

[0031] Buspirone hydrochloride was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Type Ⅱ collagen (Sigma, USA), incomplete Freund's adjuvant (Sigma), and RPMI-1640 (GIBCO).

[0032] 1.3 Instruments

[0033] American Nurie CO 2 Incubator (NU4750 type), Japanese Olympian inverted fluorescence microscope (CKX41 type), American Beckman Coulter flow cytometer (EPICSXL type), Japanese transmission electron microscope (Hitachi H-7500 type).

[0034] 1.4 Rat model preparation and cell grouping

[0035] Preparation of Collagen-Induced Arthr...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of buspirone hydrochloride and its medical application. The pharmaceutical composition of buspirone hydrochloride provided by the invention contains buspirone hydrochloride and a kind of dried rhizome of Anemarrhena anemarrhena The isolated natural product compound (I) with a novel structure, when buspirone hydrochloride and the compound (I) provided by the present invention act in combination, can make the synoviocytes stagnate in the G1 phase of the cell cycle, thereby inhibiting the proliferation of the synoviocytes, Treating synovitis; the therapeutic effect is better than that of buspirone hydrochloride or compound (I) alone. The composition of buspirone hydrochloride and compound (I) can be developed into a drug for treating synovitis, which has outstanding substantive features and significant progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of buspirone hydrochloride, in particular to a pharmaceutical composition of buspirone hydrochloride and its medical application. Background technique [0002] Buspirone Hydrochloride Tablets is a new anti-anxiety drug, which mainly changes anxiety by activating serotonin (5-HT) 1A receptors in the brain. [0003] Knee synovitis is a sterile form of inflammation that results from knee sprains and various intra-articular injuries. Abnormal function of the synovial membrane can cause the joint fluid to not be produced and absorbed normally, and effusion will occur in the knee joint. The morphological change of the synovial membrane will also invade the cartilage of the knee joint. If it is not treated in time, it will lead to osteoarthritis of the knee joint, and there is a great risk of disability. [0004] So far, there is no report on the correlation between buspirone...

Claims

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Application Information

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IPC IPC(8): C07D307/00A61K31/506A61K31/365A61P29/00A61P19/02
CPCC07D307/00A61K31/365A61K31/506
Inventor 周飞燕
Owner 周飞燕
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