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A kind of preparation method of cold water dispersible beta-carotene microcapsules

A carotene dispersion technology, applied in the field of preparation of β-carotene microcapsules, can solve the problems of large particle size, high price, and poor cold water dispersibility of microcapsules, and achieve high bioavailability, wide and convenient use, and good dispersion sexual effect

Active Publication Date: 2019-02-19
肇庆巨元生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelatin and fish gelatin have poor cold water dispersibility, require pre-treatment when used, are easily affected by microorganisms during storage, and are expensive
However, modified starch, gum arabic, and β-cyclodextrin have poor embedding ability, large microcapsule particle size, turbid state when dispersed in water, high price, and can only be produced with low content, which is not conducive to industrial production.

Method used

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  • A kind of preparation method of cold water dispersible beta-carotene microcapsules

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preparation example Construction

[0026] A preparation method of cold water dispersible β-carotene microcapsules, comprising the following steps:

[0027] 1) dispersing β-carotene, limonene and antioxidants in methyl oleate to form a suspension; wherein, limonene can increase the trans content of β-carotene microcapsules;

[0028] 2) Place the suspension obtained in step 1) in a ball mill for grinding, so that the mass percentage of particles with a particle diameter less than 10 μm in the suspension accounts for more than 90% of the total particles; the grinding medium of the ball mill is 0.8 to 1.0 mm in diameter zirconia beads;

[0029] 3) Heat the suspension ground in step 2) to 70°C, then pass through the spiral heat pipe at a temperature of 180-220°C at a rate of 1.5-1.8kg / h, and the time for passing through the spiral heat pipe is 1-3s , to obtain molecular dispersion solution;

[0030] The spiral heat pipe is beneficial to increase the contact area between the suspension and the heat pipe, quickly co...

Embodiment 1

[0035] This embodiment discloses a preparation method of cold water dispersible β-carotene microcapsules, comprising the following steps:

[0036] 1) Disperse 13g of β-carotene, 10g of limonene and 0.5g of tocopherol in 30g of methyl oleate to form a suspension;

[0037] 2) Place the suspension obtained in step 1) in a ball mill for grinding, so that the mass percentage of particles with a particle diameter less than 10 μm in the suspension accounts for more than 90% of the total particles; the grinding medium of the ball mill is 0.8 to 1.0 mm in diameter zirconia beads;

[0038] 3) Heat the suspension ground in step 2) to 70°C, then pass through the spiral heat pipe with a temperature of 210°C at a rate of 1.6kg / h, and the time for passing through the spiral heat pipe is 1.5s to complete the heat exchange, Obtain molecular dispersion solution;

[0039] 4) Pass the molecular dispersion solution obtained in step 3) into the water-soluble protective colloid prepared by 130g ca...

Embodiment 2

[0043] 1) Disperse 15g of β-carotene, 12g of limonene and 0.8g of tocopherol in 30g of methyl oleate to form a suspension;

[0044] 2) Place the suspension obtained in step 1) in a ball mill for grinding, so that the mass percentage of particles with a particle diameter less than 10 μm in the suspension accounts for more than 90% of the total particles; the grinding medium of the ball mill is 0.8 to 1.0 mm in diameter zirconia beads;

[0045] 3) Heat the suspension ground in step 2) to 70°C, then pass through a spiral heat pipe with a temperature of 200°C at a rate of 1.5kg / h, and the time for passing through the spiral heat pipe is 1s to complete the heat exchange, and obtain Molecular dispersion solution;

[0046] 4) Pass the molecular dispersion solution obtained in step 3) into the water-soluble protective colloid prepared by 145g calcium lignosulfonate and 650g water, and use a high-pressure homogenizer (APV 2000) to homogenize under a pressure of 1000bar to form Disper...

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Abstract

The invention discloses a preparing method for beta-carotene microcapsules capable of being dispersed in cold water. The preparing method includes the steps that 1, beta-carotene, limonene and antioxidant are dispersed in methyl oleate to form suspension liquid; 2, the suspension liquid obtained in the step 1 is grounded in a ball mill; 3, the suspension liquid ground in the step 2 is heated to 70 DEG C and then passes through a heat conducting pipe at the temperature of 180-220 DEG C to obtain a molecular dispersion solution; 4, the molecular dispersion solution obtained in the step 3 is introduced into water-soluble protective colloid prepared from lignosulfonate and solvent, and dispersion liquid is formed through high-pressure homogenizing; 5, spray drying is carried out on the dispersion liquid obtained in the step 4 to obtain the beta-carotene microcapsules capable of being dispersed in cold water. The beta-carotene microcapsules obtained through the method is small in particle size, high in bioavailability and easy to disperse in cold water, the production cost is relatively low, and the preparing method is beneficial for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical engineering, and more specifically, relates to a preparation method of cold water dispersible β-carotene microcapsules. Background technique [0002] The molecular formula of β-carotene is: C 40 h 56 , with a molecular weight of 536.44, is a carotenoid with a non-polar structure and 11 conjugated double bonds. It is insoluble in water, hardly soluble in methanol and ethanol, soluble in chloroform, has antioxidant properties, and is easily decomposed by light, oxygen, and heat, reducing activity. β-carotene is the most effective precursor of vitamin A. In theory, one molecule of β-carotene can be split to form two molecules of vitamin A. Vitamin A can maintain normal human visual function, such as: prevent night blindness, prevent vision loss and so on. β-carotene mainly exists in the blood plasma. Excessive β-carotene can be stored in the liver and converted into vitamin A accord...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/015A61P39/06A61P37/04A61P9/00A61P35/00
CPCA61K9/5015A61K31/015
Inventor 蔡水船何世玲刘庆辉
Owner 肇庆巨元生化有限公司
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