Method for preparing postoperative adhesion prevention materials

An anti-adhesion, solution technology, applied in surgery, medical science and other directions, can solve the problems of poor stability, low concentration, poor mechanical properties, etc., achieve excellent injectability and rheological properties, good biocompatibility, Good anti-adhesion effect

Inactive Publication Date: 2016-08-24
DONGGUAN LIANZHOU INTPROP OPERATION MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although the anti-adhesion preparations on the market have certain effects, they still have disadvantages such as inconvenient use, difficult degradation in the body, and need for surgical removal.
However, there are still some deficiencies in the anti-adhesion preparations that are often used clinically at present, such as insufficient molecular weight, low concentration, short residence time in the body, and some dosage forms are not easy to carry out large-scale production, etc.
[0004] Chinese patent (201110392570.6) discloses a combined hydrogel of cross-linked hyaluronic acid and hydroxypropyl methylcellulose, and its raw materials are composed of cross-linked hyaluronic acid 1%-3%; hydroxypropyl methylcellulose 0.05%-1%, and the rest is water. The present invention uses a high-speed dispersion method to mix hydroxypropyl methylcellulose into cross-linked hyaluronic acid. The two are simply mixed physically, and hydroxypropyl cellulose can be interspersed into In the pores of cross-linked hyaluronic acid, the pores of cross-linked hyaluronic acid are filled, and hydroxypropyl methylcellulose is fixed in the network of cross-linked hyaluronic acid by hydrogen bonding, thus effectively preventing cross-linking The degradation of hyaluronic acid prolongs the stay time of hyaluronic acid in the body, but its mechanical properties are relatively poor, its stability is not good, and its biocompatibility needs to be improved
In this invention, hyaluronic acid molecules, which have temperature-sensitive properties, good biocompatibility, and slow degradation in vivo, are physically cross-linked with hyaluronic acid molecules to obtain hyaluronic acid-methyl cellulose composite hydrogels. Glue, the resulting composite hydrogel has good mechanical properties, but its injectability and rheological properties are not so good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of postoperative anti-adhesion material, comprising the following steps:

[0026] (1) Dissolve 2.4g of polyethylene glycol in 100ml of dioxane, use 0.022g of pyridine as a catalyst, add 0.04g of succinic anhydride, reflux and stir at 110°C and 3000rpm for 2h, after reflux, stir Add anhydrous diethyl ether dropwise until no precipitation occurs, then place it in an ice bath for stirring, filter and dissolve the precipitate in dimethylformamide, add anhydrous diethyl ether dropwise until no precipitation occurs, stir in an ice bath, filter, and drying the filtered precipitate;

[0027] (2) Dissolve the precipitate obtained in step (1) and 0.131g N-hydroxysuccinimide in 5ml N,N-dimethylformamide, stir for 2h, add 0.21g dicyclohexylcarbodiimide and continue stirring 5h, stir rapidly and add anhydrous diethyl ether until the precipitation no longer occurs, then place it in an ice bath and stir for 30min, dissolve the precipitate obtained by filtration i...

Embodiment 2

[0033] A preparation method of postoperative anti-adhesion material, comprising the following steps:

[0034] (1) Dissolve 2.4g of polyethylene glycol in 200ml of dioxane, use 0.022g of pyridine as a catalyst, add 0.04g of succinic anhydride, reflux and stir at 110°C and 5000rpm for 6h, after reflux, stir Add anhydrous diethyl ether dropwise until no precipitation occurs, then place it in an ice bath for stirring, filter and dissolve the precipitate in dimethylformamide, add anhydrous diethyl ether dropwise until no precipitation occurs, stir in an ice bath, filter, and drying the filtered precipitate;

[0035] (2) Dissolve the precipitate obtained in step (1) and 0.131g N-hydroxysuccinimide in 5ml N,N-dimethylformamide, stir for 3h, add 0.21g dicyclohexylcarbodiimide and continue stirring 12h, stir rapidly and add anhydrous diethyl ether until the precipitation no longer occurs, then place it in an ice bath and stir for 50min, dissolve the precipitate obtained by filtration ...

Embodiment 3

[0041] A preparation method of postoperative anti-adhesion material, comprising the following steps:

[0042] (1) Dissolve 2.4g of polyethylene glycol in 150ml of dioxane, use 0.022g of pyridine as a catalyst, add 0.04g of succinic anhydride, and stir under reflux for 3 hours at 110°C and 3500rpm. After the reflux is completed, stir Add anhydrous diethyl ether dropwise until no precipitation occurs, then place it in an ice bath for stirring, filter and dissolve the precipitate in dimethylformamide, add anhydrous diethyl ether dropwise until no precipitation occurs, stir in an ice bath, filter, and drying the filtered precipitate;

[0043] (2) Dissolve the precipitate obtained in step (1) and 0.131g N-hydroxysuccinimide in 5ml N,N-dimethylformamide, stir for 2.2h, add 0.21g dicyclohexylcarbodiimide and continue Stir for 7 hours, stir quickly and add anhydrous diethyl ether until the precipitation no longer occurs, then place it in an ice bath and stir for 35 minutes, dissolve ...

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PUM

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Abstract

The invention discloses a preparation method of postoperative anti-adhesion material, which comprises the following steps: firstly reacting polyethylene glycol succinimide succinic anhydride with deacetylated hyaluronic acid, succinyl chitosan and polylysine The cross-linked active ester is prepared, and then the cross-linked active ester is reacted with methyl cellulose to form a film to obtain postoperative anti-adhesion material. The postoperative anti-adhesion material prepared by the invention has good biocompatibility, excellent mechanical properties, good injectability and rheological properties, and has relatively long residence time in the body and good anti-adhesion effect.

Description

Technical field: [0001] The invention relates to the technical field of medical biomaterials, in particular to a preparation method of postoperative anti-adhesion materials. Background technique: [0002] After surgery, tissue adhesion is prone to occur, which is not only a common clinical phenomenon in the field of surgery, but also a process that patients must go through during the healing process. Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. If the adhesion phenomenon occurs in the abdominal cavity, pelvic bone and other operations, it will cause serious complications, such as abdominal and pelvic cavity can cause adhesive ileus, recurrent laryngeal nerve injury after thyroid surgery and pelvic tissue adhesion. female infertility. [0003] The main causes of adhesions are the following: inflammation due to ischemia, trauma during surgery, presence of foreign bodies in the body, bacterial infect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
CPCA61L31/041A61L31/14C08L29/14C08L1/28C08L5/08
Inventor 王文庆
Owner DONGGUAN LIANZHOU INTPROP OPERATION MANAGEMENT CO LTD
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