Bio-based polyamide polycaprolactone composite drug-loaded wound dressing and preparation method thereof
A bio-based polyamide, polycaprolactone technology, applied in the fields of medical science, filament/thread forming, bandages, etc., to achieve the effect of inhibiting resuscitation, cytotoxicity and environmental stability, no pollution, and good processing performance
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0033] Embodiment 1: Preparation of bio-based polyamide terpolymer
[0034]Add 78.06g (ie 0.6mol) of itaconic acid into 200ml of absolute ethanol, heat to 70°C to dissolve it completely. Add 52.90 g (ie 0.3 mol) of decanediamine and 26.45 g (ie 0.3 mol) of butanediamine into 200 ml of absolute ethanol, and heat to 70° C. to dissolve them completely. The molar ratio of the three monomers itaconic acid: butanediamine: decanediamine is 2:1:1. Pour the ethanol solution of the above-mentioned mixed diamine monomer into the ethanol solution of the above-mentioned itaconic acid monomer, and continue to stir until crystals are precipitated. After complete cooling and suction filtration, the crystals are obtained, and the obtained crystals are washed 3 times with absolute ethanol. Then transfer it to a petri dish and put it into a vacuum drying oven at 40° C. to dry for 12 hours to obtain an amide salt. Add the above-mentioned amide salt into a three-necked flask equipped with mechan...
Embodiment 2
[0035] Example 2: Preparation of bio-based polyamide / polycaprolactone drug-loaded wound dressing
[0036] 1) drying: drying the bio-based polyamide prepared in Example 1 under vacuum conditions at 40°C for 48h;
[0037] 2) Dissolution: Weigh 1 g of bio-based polyamide and 1 g of polycaprolactone (PCL) particles and dissolve them in trifluoroethanol to prepare a polymer solution with a mass fraction of bio-based polyamide / polycaprolactone of 10 wt.%. . The prepared solution was stirred on a magnetic stirrer for 24 h and then mixed evenly. After standing for 3 hours, add 0.1g of MNA, then stir for 24 hours and let stand for 2 hours before use. After standing, there is no precipitate in the solution.
[0038] 3) Electrospinning: Inhale the medicated bio-based polyamide / polycaprolactone solution after standing still into a 10ml disposable injection needle tube to remove the residual air in the needle tube, insert the needle with the removed tip firmly on the needle tube and fix ...
Embodiment 3
[0039] Example 3: Preparation of bio-based polyamide / polycaprolactone drug-loaded wound dressing
[0040] 1) drying: drying the bio-based polyamide prepared in Example 1 under vacuum conditions at 40°C for 48h;
[0041] 2) Dissolution: Weigh 1 g of bio-based polyamide and 1 g of polycaprolactone (PCL) particles and dissolve them in trifluoroethanol to prepare a polymer solution with a mass fraction of bio-based polyamide / polycaprolactone of 10 wt.%. . The prepared solution was stirred on a magnetic stirrer for 24 h and then mixed evenly. After standing for 3 hours, add 0.2g of MNA, stir for 24 hours, and then use after standing for 2 hours. After standing, there is no precipitate in the solution.
[0042] 3) Electrospinning: Inhale the medicated bio-based polyamide / polycaprolactone solution after standing still into a 10ml disposable injection needle tube to remove the residual air in the needle tube, insert the needle with the removed tip firmly on the needle tube and fix i...
PUM
| Property | Measurement | Unit |
|---|---|---|
| glass transition temperature | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More