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Traditional Chinese medicine alcohol extract for treating diabetic nephropathy and preparation method and application thereof

A technology of diabetic nephropathy and extract, which is applied in the field of traditional Chinese medicine extracts, can solve the problems of lack of specific means in the treatment of diabetic nephropathy, and achieve the effects of reducing urinary protein excretion rate, delaying renal function decline, and lowering blood sugar concentration

Inactive Publication Date: 2016-09-21
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment of diabetic nephropathy lacks effective specific means

Method used

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  • Traditional Chinese medicine alcohol extract for treating diabetic nephropathy and preparation method and application thereof
  • Traditional Chinese medicine alcohol extract for treating diabetic nephropathy and preparation method and application thereof
  • Traditional Chinese medicine alcohol extract for treating diabetic nephropathy and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the extraction of Chinese medicine extract

[0031] Weigh the following prescription:

[0032] Dijincao 150g, Salvia 200g, Raw Astragalus 150g, Anemarrhena 100g, Coptis 60g.

[0033] After mixing the traditional Chinese medicines, add them to 6 times the mass of 60% ethanol aqueous solution, soak for 30 minutes, then reflux and extract twice, each extraction for 1 hour, filter, combine the filtrates, concentrate, and evaporate to dryness, that is Chinese medicine extract of the present invention.

[0034] The Chinese medicine extract prepared in this example is in the form of an extract, 202 g in total, so 1 g of the Chinese medicine extract is equivalent to 3.267 g of the Chinese medicine composition.

Embodiment 2

[0035] Embodiment 2, the influence of Chinese medicine extract of the present invention on blood sugar and renal function

[0036] 1. Animals

[0037] 40 male spontaneous type 2 diabetes model KK-Ay mice, 8w old, Beijing Huafukang Biotechnology Co., Ltd., license number: SCXK (Beijing) 2014-0004; 10 healthy male C57BL / 6J mice, 8w old, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001. KK-Ay mice were fed with high-fat diet, Beijing Huafukang Biotechnology Co., Ltd., license number: SCXK (Beijing) 2014-0008; C57BL / 6J mice were fed with normal diet. All animals had free access to water, and were adaptively fed for 1 week at room temperature (22±1)°C in an SPF environment with a 12-h photoperiod. Take blood from the tip of the tail to measure the random blood glucose of KK-Ay mice ≥11.1mmol·L -1 Or fasting blood glucose (FBG) ≥ 7.0mmol·L -1 That is, as a model of diabetes.

[0038] 2. Dosage of mice in each group

[003...

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Abstract

The invention discloses a traditional Chinese medicine alcohol extract for treating diabetic nephropathy and a preparation method and application thereof. The preparation method comprises the following steps of: extracting a traditional Chinese medicine composition with an ethanol aqueous solution, filtering to obtain filtrate, and concentrating and drying to obtain the traditional Chinese medicine extract, wherein the traditional Chinese medicine composition comprises humifuse euphorbia herb, radix salviae miltiorrhizae, raw astragalus mongholicus, rhizoma anemarrhenae and coptis chinensis in a mass ratio of (1.32-5.34) to (1.76-7.12) to (0.88-6) to (0.88-3.56) to 1. The traditional Chinese medicine extract is obtained by carrying out alcohol extraction on the traditional Chinese medicine composition which comprises humifuse euphorbia herb, radix salviae miltiorrhizae, raw astragalus mongholicus, rhizoma anemarrhenae and coptis chinensis, and the method is simple. The traditional Chinese medicine extract is capable of lowering blood sugar concentration, lowering the content of urine micro albumin, lowering the content of urine urea, and lowering the ratio of the content of urine micro albumin to the content of the urine creatinine, and thus the traditional Chinese medicine extract can be used for preventing and / or treating diabetic nephropathy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine alcohol extract for treating diabetic nephropathy, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine extracts. Background technique [0002] Diabetic nephropathy is a serious microvascular complication of diabetes, the main cause of end-stage renal failure, and one of the main causes of death and disability in diabetes. At present, there is no effective specific means for the treatment of diabetic nephropathy. Traditional Chinese medicine has accumulated rich experience in the field of treatment of diabetic nephropathy, so it is expected to provide a traditional Chinese medicine extract that can reduce the excretion rate of urinary protein in patients with diabetic nephropathy, delay the decline of renal function in patients, and improve the quality of life of patients. Contents of the invention [0003] The object of the present invention is...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P3/10A61P13/12
CPCA61K36/47A61K36/481A61K36/537A61K36/718A61K36/8964A61K2300/00
Inventor 王学美黎巍威洪金妮富宏屠鹏飞姜勇曾祥腾高云佳
Owner PEKING UNIV FIRST HOSPITAL
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