Absorbable antibacterial hemostatic microsphere, preparation method and application thereof

A technology of microspheres and lysozyme, which is applied in the fields of application, pharmaceutical formulation, and medical science, can solve the problems of unsuitable hemostatic powder, difficult to degrade and absorb, etc., and achieve the effects of long storage time, convenient use, and fast degradation speed
CN105963766AInactive Publication Date: 2016-09-28ZHEJIANG SCI-TECH UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG SCI-TECH UNIV
Publication Date
2016-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an absorbable antibacterial hemostatic microsphere, a preparation method and application of the absorbable antibacterial hemostatic microsphere. The absorbable antibacterial hemostatic microsphere is prepared from carboxymethyl chitosan, sodium alginate, gelatin and lysozyme. The absorbable antibacterial hemostatic microsphere disclosed by the invention can be used for carrying out quick hemostasis on a massive haemorrhage wound and preventing the massive haemorrhage wound from being infected by bacteria; the absorbable antibacterial hemostatic microsphere has good biocompatibility, can be degraded and absorbed and is capable of promoting the wound healing. The invention also discloses the effect of the application of the composite absorbable antibacterial hemostatic microsphere in hemostasis of New Zealand rabbit hemihepatectomy.
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Description

technical field

[0001] The invention relates to an absorbable antibacterial hemostatic microsphere and a preparation method thereof. Background of the invention

[0002] Hemostatic dressings have the largest variety of hemostatic agents and are most widely used. Among them, dry fibrin dressings, zeolite dressings, and chitosan dressings are particularly representative.

[0003] Dry fibrin dressings are made primarily by adding fibrin and thrombin to gauze to improve the hemostatic effect of standard gauze. The mechanism of hemostasis is to provide exogenous substrates for the coagulation reaction. The material composition can be absorbed, and the hemostatic effect is stable, but the cost is expensive, and the price is 500-1000 US dollars. The source of ingredients, the fragility of the material itself, the problem of microbial inactivation technology and the high price limit the application of this type of dressing.

[0004] Zeolite dressing is mainly made of molecular s...

Claims

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