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Titanium dioxide nanotube/hydroxyapatite composite coating used for medical porous titanium and preparation method of titanium dioxide nanotube/hydroxyapatite composite coating

A technology of hydroxyapatite and titanium dioxide, which is applied in the fields of coating, medical science, tissue regeneration, etc., can solve problems such as thermal expansion coefficient mismatch, decrease in bonding strength, and failure of implants, and achieve strong interface bonding and improve bonding Strength, bioactive effect

Inactive Publication Date: 2016-09-28
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the serious mismatch of thermal expansion coefficient between hydroxyapatite and titanium or titanium alloy, there is a macroscopic interface between the coating and the substrate. As the insertion time prolongs, the bonding strength decreases, and the coating falls off, causing the failure of the implant. More and more, causing great suffering to patients

Method used

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  • Titanium dioxide nanotube/hydroxyapatite composite coating used for medical porous titanium and preparation method of titanium dioxide nanotube/hydroxyapatite composite coating
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Effect test

Embodiment 1

[0030] (1) The size is 10×10×1mm 3 The porous titanium is used as the matrix, and the sample is subjected to 360 # 、600 # , 800 # 、1000 # , 1200 # Water sandpaper was polished in turn until the surface was smooth, and the polished samples were ultrasonically cleaned in deionized water, ethanol, and acetone solutions for 5 minutes. Dry at room temperature. Place it in 0.3M NH 4 In the glycerol / water (1:1vol.%) electrolyte of F, set the anodic oxidation voltage to 15V, and the oxidation time to 1h, prepare titanium dioxide nanotubes in the porous pure titanium restricted network structure, and after the oxidation is completed, the sample is placed in ethanol solution Ultrasonic cleaning in medium and air dry naturally.

[0031] (2) After the above sample is cleaned, it is vertically immersed in phosphate simulated body fluid to grow, and the simulated body fluid is composed of NaCl, KCl, CaCl 2 , NaHCO 3 , MgCl 2 , MgSO 4 ·7H 2 O, C 6 h 12 o 6 , KH 2 PO 4 , Na ...

Embodiment 2

[0034] (1) The size is 10×10×1mm 3 The porous titanium is used as the matrix, and the sample is subjected to 360 # 、600 #, 800 # 、1000 # , 1200 # Water sandpaper was polished in turn until the surface was smooth, and the polished samples were ultrasonically cleaned in deionized water, ethanol, and acetone solutions for 6 minutes. Dry at room temperature. Place it in 0.2M NH 4 In the glycerol / water (1:1vol.%) electrolyte solution of F, set the anodic oxidation voltage to 2V, and the oxidation time to 2h, prepare titanium dioxide nanotubes in the porous titanium alloy restricted network structure, and after the oxidation is completed, the sample is placed in ethanol solution Ultrasonic cleaning in medium and air dry naturally.

[0035] (2) After the above sample is cleaned, it is vertically immersed in phosphate simulated body fluid to grow, and the simulated body fluid is composed of NaCl, KCl, CaCl 2 , NaHCO 3 , MgCl 2 , MgSO 4 ·7H 2 O, C 6 h 12 o 6 , KH 2 PO ...

Embodiment 3

[0038] (1) The size is 10×10×1mm 3 The porous titanium is used as the matrix, and the sample is subjected to 360 # 、600 # , 800 # 、1000 # , 1200 # Water sandpaper was polished in turn until the surface was smooth, and the polished samples were ultrasonically cleaned in deionized water, ethanol, and acetone solutions for 5 minutes. Dry at room temperature. Place it in 0.4M NH 4 In the glycerol / water (1:1vol.%) electrolyte of F, set the anodic oxidation voltage to 20V, and the oxidation time to 0.5h, prepare titanium dioxide nanotubes in the porous titanium alloy restricted network structure, and after the oxidation is completed, the sample is placed in ethanol The solution was ultrasonically cleaned and air-dried naturally.

[0039] (2) After the above sample is cleaned, it is vertically immersed in phosphate simulated body fluid to grow, and the simulated body fluid is composed of NaCl, KCl, CaCl 2 , NaHCO 3 , MgCl 2 , MgSO 4 ·7H 2 O, C 6 h 12 o 6 , KH 2 PO 4 ...

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Abstract

The invention relates to a titanium dioxide nanotube / hydroxyapatite composite coating used for medical porous titanium and a preparation method of the titanium dioxide nanotube / hydroxyapatite composite coating, belonging to the technical field of the improvement for medical titanium materials. According to the titanium dioxide nanotube / hydroxyapatite composite coating used for medical porous titanium, porous titanium is taken as a substrate, a composite coating is distributed on the inner surfaces and the outer surfaces of hole structures of porous titanium, and specifically, the composite coating is composed of a titanium dioxide nanotube and hydroxyapatite deposited on the titanium dioxide nanotube. The titanium dioxide nanotube / hydroxyapatite composite coating used for medical porous titanium is uniform and compact, and has strong interface bonding strength, as well as good biological activity and good compatibility. The invention further provides the preparation method of the composite coating which is characterized in that a preparation process is simple, the period is short, and the operability is strong.

Description

technical field [0001] The invention relates to a titanium dioxide nanotube / hydroxyapatite composite coating for medical porous titanium and a preparation method thereof, and belongs to the technical field of improving medical titanium materials. Background technique [0002] Titanium alloys are widely used in the fields of orthopedics and oral restoration due to their light weight, good biocompatibility, and high corrosion resistance. However, its elastic modulus is high, which does not match the elastic modulus of human bone tissue, and it is prone to stress shielding. In recent years, porous titanium can achieve good biomechanical compatibility through controllable pore structure parameters. However, as a biologically inert implant, porous titanium is completely different from the composition of natural bone. After implantation, there is only a mechanical interlocking osseointegration between the two, rather than chemical osseointegration, so the biological activity is n...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/56
CPCA61L27/306A61L27/06A61L27/32A61L27/56A61L2430/02A61L2430/12
Inventor 郭美卿王晓君陈静冯鹏飞
Owner TAIYUAN UNIV OF TECH
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