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Modified hydroxypropyl starch, preparation method of same, plant hollow capsule, and preparation method thereof

A technology of plant hollow capsules and hydroxypropyl starch, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. Stability and other problems, to achieve the effect of improving the degree of elongation and rupture, solving the brittleness of the capsule shell, and delaying the aging phenomenon

Active Publication Date: 2016-10-05
深圳市思颖柏霖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original starch is insoluble in cold water, and the viscosity of the starch paste is unstable. It is necessary to modify the starch to improve its physical and chemical properties.
However, plant capsules based on modified starch generally have disadvantages such as complex operation and high capsule brittleness, which limit the large-scale application of starch-based capsule technology.
Many researchers use various natural colloids as strengthening and toughening agents, hoping to solve the problem that the brittleness of starch capsules is relatively large. For example, in patent document CN103830737, the combination of locust bean gum and lentinan is used as a strengthening and toughening agent for starch capsules. 201410309648.7, CN200510013285.3 and patent 201410174673.9 also prepare vegetable capsules by simply adding and mixing colloidal substances such as starch and natural polysaccharides, but because the compatibility between starch and natural polymers is not good, simple addition is difficult to enhance Toughening effect, therefore, it is necessary to provide a modified starch with excellent characteristics and based on this modified starch to provide a low cost, low brittle vegetable capsule and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of plant hollow capsules, comprising the following steps:

[0036] a. Prepare modified starch:

[0037] (1) Cross-linking reaction: 10 parts of hydroxypropyl starch, 3 parts of hydroxyethyl starch, 2 parts of carboxymethyl starch, 0.1 part of sodium trimetaphosphate, 0.2 part of sodium hexametaphosphate and 85 parts of deionized water were added to In the reaction vessel, adjust the pH of the reaction system to 10, heat to 50° C., and perform a crosslinking reaction for 5 hours to obtain a reaction solution;

[0038] (2) Extract the product: After the reaction solution in step (1) is down to room temperature, the reaction solution is concentrated to 1 / 3 of the original volume, and 3 times the volume of ethanol is added to precipitate the product, and then filtered, washed, Drying treatment to obtain modified hydroxypropyl starch, and using a rotational viscometer NDJ-1 at 25°C to measure the viscosity of the modified hydroxypropyl starch with a mas...

Embodiment 2

[0049] A preparation method of plant hollow capsules, comprising the following steps:

[0050] a. Prepare modified starch:

[0051] (1) Cross-linking reaction: Add 10 parts of hydroxypropyl starch, 5 parts of mannan, 0.5 parts of sodium tripolyphosphate and 85 parts of deionized water into the reaction vessel, adjust the pH of the reaction system to 9, and heat to 40 °C, carry out the crosslinking reaction for 3 hours to obtain the reaction solution;

[0052] (2) Extract the product: After the reaction solution in step (1) is down to room temperature, the reaction solution is concentrated to 1 / 3 of the original volume, and 3 times the volume of ethanol is added to precipitate the product, and then filtered, washed, Drying treatment to obtain modified hydroxypropyl starch, and using a rotational viscometer NDJ-1 at 25°C to measure the viscosity of the modified hydroxypropyl starch with a mass concentration of 5% is 150mPa·s;

[0053] b. Preparation of capsules:

[0054] (3) ...

Embodiment 3

[0059] A preparation method of plant hollow capsules, comprising the following steps:

[0060] a. Prepare modified starch:

[0061] (1) Crosslinking reaction: Add 20 parts of hydroxypropyl starch, 5 parts of tamarind gum, 0.3 parts of phosphorus oxychloride and 80 parts of deionized water into the reaction vessel, adjust the pH of the reaction system to 8, and heat to 50 °C, carry out the crosslinking reaction for 2 hours to obtain the reaction solution;

[0062] (2) Extract the product: After the reaction solution in step (1) is down to room temperature, the reaction solution is concentrated to 1 / 2 of the original volume, and 1.5 times the volume of isopropanol is added to precipitate the product, and then filtered, Washing and drying to obtain modified hydroxypropyl starch, and using a rotational viscometer NDJ-1 at 25°C to measure the viscosity of the modified hydroxypropyl starch with a mass concentration of 5% is 320mPa·s;

[0063] b. Preparation of capsules:

[0064] ...

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Abstract

The invention provides modified hydroxypropyl starch and a preparation method of the same. The modified hydroxypropyl starch is excellent in performance and is prepared from hydroxypropyl starch and toughening gum under the effect of a crosslinker through a crosslinking reaction of activating hydroxyl groups. The invention also provides a plant hollow capsule and a preparation method thereof. The preparation method includes the steps of physical mixing of modified hydroxypropyl starch as a raw material with a gelatinizer, a coagulant, a plasticizer and the like, gum dipping, drying, shell pulling, cutting and sleeving. The plant hollow capsule is excellent in quality and effectively solves the problems of crispy capsule shells, excessive high capsule production cost and complex operations in production of plant hollow capsules in the prior art.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical excipients, and in particular relates to a modified hydroxypropyl starch and a preparation method thereof, a plant hollow capsule and a preparation method thereof. Background technique [0002] As one of the most widely used dosage forms at present, capsules have the advantages of masking drug taste, high drug efficacy, controlled and sustained release, etc., and are widely used in medicine, health care products, and functional food industries. Traditional capsules generally use gelatin obtained by hydrolysis of animal skin and bone as the capsule shell material, but gelatin capsules are easy to breed microorganisms, easy to absorb moisture, poor flexibility, high price, and unsuitable for people with special cultural beliefs, etc. defect. Compared with gelatin capsules, adopting plant raw materials to prepare capsules can obviously improve the above-mentioned shortcomings. [0003] As a ...

Claims

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Application Information

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IPC IPC(8): C08B31/00C08B31/06A61K47/36A61K9/48
Inventor 唐汝培陈伟崇姜琼
Owner 深圳市思颖柏霖生物科技有限公司
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