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Preparation method for hybrid composite coating used for magnesium-based biological material surface medication

A biological material and hybrid composite technology, applied in the field of preparation of hybrid composite coatings, can solve the problems of local tissue inflammation, excessive corrosion rate, etc., reduce corrosion rate, simple and controllable process, and improve coating quality Effect

Inactive Publication Date: 2016-10-12
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After magnesium and its alloy materials are implanted into the human body as biomaterials, they will rapidly degrade in the medium containing chloride ions in the human body, making them unable to maintain enough time and fail early, and their pitting behavior may also induce severe inflammation in local tissues reaction
This excessive corrosion rate is an urgent problem to be solved

Method used

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  • Preparation method for hybrid composite coating used for magnesium-based biological material surface medication
  • Preparation method for hybrid composite coating used for magnesium-based biological material surface medication
  • Preparation method for hybrid composite coating used for magnesium-based biological material surface medication

Examples

Experimental program
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Effect test

Embodiment 1

[0028] A method for preparing a hybrid composite coating for surface modification of a magnesium-based biomaterial, the specific steps of which are:

[0029] A. Grinding and polishing the pure magnesium material, cleaning with ethanol, cleaning with pickling solution, and drying in vacuum;

[0030] B. Place the pure magnesium material obtained in step A in a NaOH solution with a temperature of 60° C. and a concentration of 3 mol / L, and soak for 12 hours to obtain an alkali-activated pure magnesium material;

[0031] C, the preparation concentration is 0.1mol / L (NH 4 ) 2 TiF 6 Solution and H at a concentration of 0.3mol / L 3 B0 3 Solution, uniformly mix the two at a volume ratio of 1:1 to prepare an inorganic mixed solution, and use HF to adjust the pH value of the inorganic mixed solution to 2.8;

[0032] Another organic solution with a concentration of 5g / L—phytic acid solution was prepared, and the pH value of the phytic acid solution was adjusted to 5.5 with ammonia wat...

Embodiment 2

[0044] A method for preparing a hybrid composite coating for surface modification of a magnesium-based biomaterial, the specific steps of which are:

[0045] A. Grinding and polishing the pure magnesium material, cleaning with ethanol, cleaning with pickling solution, and drying in vacuum;

[0046] B. Place the pure magnesium material obtained in step A in a NaOH solution with a temperature of 60° C. and a concentration of 2 mol / L, and soak for 12 hours to obtain an alkali-activated pure magnesium material;

[0047] C, the preparation concentration is 0.2mol / L (NH 4 ) 2 TiF 6 solution and a concentration of 0.4mol / L of H 3 B0 3 Solution, the two are evenly mixed according to the volume ratio of 1:1 to prepare an inorganic mixed solution, and the pH value of the inorganic mixed solution is adjusted to 2.7 with HF;

[0048] Another organic solution with a concentration of 2g / L—phytic acid solution was prepared, and the pH value of the phytic acid solution was adjusted to 5 ...

Embodiment 3

[0053] A method for preparing a hybrid composite coating for surface modification of a magnesium-based biomaterial, the specific steps of which are:

[0054] A. Grinding and polishing the pure magnesium material, cleaning with ethanol, cleaning with pickling solution, and drying in vacuum;

[0055] B. Place the pure magnesium material obtained in step A in a NaOH solution with a temperature of 50° C. and a concentration of 4 mol / L, and soak for 6 hours to obtain an alkali-activated pure magnesium material;

[0056] C, the preparation concentration is 0.1mol / L (NH 4 ) 2 TiF 6 Solution and H at a concentration of 0.2mol / L 3 B0 3 Solution, the two are uniformly mixed according to the volume ratio of 1:1 to prepare an inorganic mixed solution, and the pH value of the inorganic mixed solution is adjusted to 2.9 with HF;

[0057] Another organic solution with a concentration of 10g / L—hydroxyethylidene diphosphonic acid solution was prepared, and the pH value of the hydroxyethyl...

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Abstract

The invention discloses a preparation method for a hybrid composite coating used for magnesium-based biological material surface medication. The preparation method mainly comprises the following steps: A, grinding and polishing a magnesium-based biological material, cleaning the magnesium-based biological material, and vacuum-drying the magnesium-based biological material; B, soaking the magnesium-based biological material into a NaOH solution for 6-12 hours to obtain an alkaline-activated magnesium-based biological material; C, mixing a (NH4)2TiF6 solution with a H3BO3 solution to prepare an inorganic mixed solution with a pH being 2.7-2.9; preparing an organic solution with concentration being 2-10g / L, and regulating the pH value of the organic solution to 5-6, wherein the organic solution is a solution of phosphonic substances; D, soaking the magnesium-based biological material into the organic solution, and preserving the heat for 10-20 minutes at a temperature being 30-40 DEG C; E, soaking the magnesium-based biological material into the inorganic mixed solution, and preserving the heat for 30-40 minutes at a temperature being 45-55 DEG C; and F, repeating steps D and E for 1-10 times, thereby obtaining the hybrid composite coating. The coating prepared by the preparation method is good in binding force with the magnesium-based biological material, so that corrosion resistance and mechanical property of the magnesium-based biological material are improved, and therefore, the coating has very good biocompatibility; and the preparation method is gentle in preparation condition and is simple and controllable in process.

Description

technical field [0001] The invention relates to a method for preparing a hybrid composite coating for surface modification of magnesium-based biomaterials. Background technique [0002] Magnesium alloy is a very ideal modern industrial structural material. It was widely used in the aerospace industry in the early days. At present, it also has great development in the fields of optical instruments, electronics industry, and transportation. In recent years, magnesium and its alloys have attracted great attention from the biomaterials community. It has good mechanical properties and is harmless to the human body. It can be gradually degraded in the human body through corrosion, and the generated magnesium ions can be absorbed by the surrounding muscle tissue or It is excreted by body fluids and does not need to be removed after implantation. In addition, magnesium has good biological properties. Magnesium ions can promote calcium deposition, enhance bone conductivity, reduce b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/34C23C22/57C23C22/78A61L27/04A61L27/30A61L27/50
CPCA61L27/047A61L27/306A61L27/50A61L2400/18A61L2420/04C23C22/34C23C22/57C23C22/78
Inventor 万国江张旋陈英奇赵升毛金龙黄楠
Owner SOUTHWEST JIAOTONG UNIV
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