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Medical composite chitosan gel containing antibacterial drug

A chitosan gel, antibacterial drug technology, applied in drug delivery, pharmaceutical science, pharmaceutical formulations, etc., can solve the problems of destroying growth factors, secondary wounds, easy adhesion of new tissues, etc., to promote wound healing and performance. Excellent, preventive and control effects of wound infection

Inactive Publication Date: 2016-10-26
SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings used on wounds mainly play an isolation and antibacterial role, but often lead to dryness of the wound, damage to healthy growth factors, and easy adhesion to new tissue, which will lead to secondary trauma of the wound when the dressing is removed

Method used

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  • Medical composite chitosan gel containing antibacterial drug
  • Medical composite chitosan gel containing antibacterial drug
  • Medical composite chitosan gel containing antibacterial drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Medical Composite Chitosan Gel Containing Antibacterial Drugs - Prescription of Amorphous Gel:

[0047]

[0048]

[0049] Preparation method: (1) Weigh the prescribed amount of glacial acetic acid, add purified water to prepare 1% glacial acetic acid solution, because chitosan can only be dissolved in weak acid, so use pH adjuster acetic acid to configure glacial acetic acid solution to dissolve Chitosan; (2) chitosan, hypromellose and glycerin are added to the above-mentioned 1% glacial acetic acid, and left to swell overnight; (3) gentamicin sulfate is dissolved with an appropriate amount of purified water, and added Into the gel formed in step (2), stir and mix evenly; (4) adjust the pH value of the gel to 4-7 with aqueous sodium hydroxide solution, make up the remaining purified water, sterilize and pack to obtain the medical compound Chitosan gel.

[0050] The prepared gel is suitable for acute incisions (various surgical incisions, small debridement operati...

Embodiment 2

[0052] Medical Composite Chitosan Gel Containing Antibacterial Drugs - Prescription of Amorphous Gel:

[0053]

[0054]

[0055] Preparation method: (1) Weigh carboxymethyl chitosan, sodium carboxymethyl cellulose and glycerin in the prescribed amount, add to appropriate amount of purified water, stir and mix, and place overnight; (2) Weigh the prescribed amount of Crowphosphonate Add gentamicin to the gel formed in step (1), stir and mix evenly; (3) adjust the pH value of the gel to 4-7 with hydrochloric acid / sodium hydroxide, make up 100 parts of purified water, and let stand Degassing, sterilizing and packaging to obtain the medical composite chitosan gel.

[0056] The prepared gel can be applied to acute incisions (various surgical incisions, small debridement operations, small skin trauma and abrasions), chronic wounds (decubitus ulcers, vascular lesion ulcers, osteomyelitis, tophi ulceration, etc.), and can Provide a moist wound healing environment, assist wound h...

Embodiment 3

[0058] Medical Composite Chitosan Gel Containing Antibacterial Drugs - Prescription of Amorphous Gel:

[0059]

[0060] Preparation method: (1) Weigh carboxymethyl chitosan, sodium alginate and propylene glycol in the prescribed amount, add to purified water, let it swell overnight; (2) dissolve clindamycin hydrochloride with appropriate amount of purified water, add to In the gel formed in step (1), stir and mix evenly; (3) Use hydrochloric acid / sodium hydroxide aqueous solution to adjust the pH value of the gel to 7-9, make up the remaining amount of purified water, sterilize and pack to obtain medical use Composite chitosan gel.

[0061] The prepared gel can be applied to acute incisions (various surgical incisions, small debridement operations, small skin trauma and abrasions), chronic wounds (decubitus ulcers, vascular lesion ulcers, osteomyelitis, tophi ulceration, etc.), and can Provide a moist wound healing environment, assist wound healing and play a role in contr...

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PUM

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Abstract

The invention discloses a medical composite chitosan gel containing antibacterial drugs. In parts by weight, the medical composite chitosan gel comprises the following components: 0.5 to 10 parts of chitosan polymer materials, 0.05 ~2 parts of antibacterial drug, 0~10 parts of thickener, 1~25 parts of humectant and 53~98.45 parts of purified water. The medical composite chitosan gel containing antibacterial drugs of the present invention can effectively maintain a moist environment for wound healing, promote wound healing and prevent and control wound infection. The drug combines the advantages of chitosan polymer materials such as moisture absorption, moisturizing, antibacterial, and hemostasis with the role of antibacterial drugs in preventing and controlling infection, and prepares a gel with excellent performance.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a medical composite chitosan gel containing antibacterial drugs. Background technique [0002] The skin and mucous membranes of the human body are the barriers to maintain the stability of the human body environment and prevent the invasion of microorganisms. Damage to the skin and mucous membranes caused by ulcers, trauma, burns and inflammation will cause a series of problems in the body, such as bacterial infection, increased metabolism, Excessive water and protein loss, endocrine and immune system dysfunction, etc., may be life-threatening in severe cases. When the skin and mucous membrane are injured, a suitable dressing should be selected to cover the wound. It can maintain a moist environment for the wound, absorb secretions, relieve pain and control bleeding, thereby promoting rapid wound healing. [0003] The use of dressings is an important means of maintaining...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/404A61L2300/412A61L2400/04C08L5/08
Inventor 莫始奎
Owner SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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