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Method for preparing monodisperse calcium alginate microspheres based on emulsion liquid film mass transfer

A calcium alginate and monodisperse technology, which is applied in the preparation of microspheres, pharmaceutical formulations, microcapsule preparations, etc., can solve the problems of difficult to achieve batch continuous production, cumbersome gel plate preparation process, and poor gel network uniformity , to achieve the effect of convenient batch continuous production, good size controllability and uniform size

Active Publication Date: 2018-05-04
SOUTHWEST PETROLEUM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The uniformity of the gel network of calcium alginate microspheres prepared by the mixed cross-linking method is poor, and there is a risk of uncontrolled reaction to block the microchannel
In recent years, some researchers have reported a method for preparing calcium alginate microspheres based on the ion mass transfer process at the gel / droplet interface (see H. Hirama, et al, Langmuir, 2012, 29, 519-524). The preparation process of the required gel plates is cumbersome, and it is difficult to achieve batch continuous production

Method used

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  • Method for preparing monodisperse calcium alginate microspheres based on emulsion liquid film mass transfer
  • Method for preparing monodisperse calcium alginate microspheres based on emulsion liquid film mass transfer
  • Method for preparing monodisperse calcium alginate microspheres based on emulsion liquid film mass transfer

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Experimental program
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Effect test

Embodiment 1

[0040] (1) Preparation of inner water phase, middle oil phase, outer water phase and collected water phase fluid

[0041] Preparation of the inner water phase fluid: the inner water phase fluid is made of sodium alginate, water-soluble emulsifier Pluronic F127 and deionized water, the mass ratio of sodium alginate to deionized water is 0.010:1, and the water-soluble emulsifier Pluronic F127 The mass ratio to deionized water is 0.020:1; sodium alginate and water-soluble emulsifier Pluronic F127 are added to deionized water at normal pressure and room temperature and stirred until completely dissolved, and the resulting mixed solution is the internal water phase;

[0042] The configuration of the intermediate oil phase fluid: the intermediate oil phase is made of soybean oil, benzyl benzoate and oil-soluble emulsifier, the volume ratio of soybean oil and benzyl benzoate is 2:1, and the emulsifier is mixed with soybean oil and benzyl benzoate The mass ratio of the ester mixture i...

Embodiment 2

[0051] (1) Preparation of inner water phase, middle oil phase, outer water phase and collected water phase fluid

[0052] Preparation of the inner water phase fluid: the inner water phase fluid is made of sodium alginate, water-soluble emulsifier Pluronic F108 and deionized water, the mass ratio of sodium alginate to deionized water is 0.002:1, and the water-soluble emulsifier Pluronic F108 The mass ratio to deionized water is 0.005:1; sodium alginate and water-soluble emulsifier Pluronic F108 are added to deionized water at normal pressure and room temperature and stirred until completely dissolved, and the resulting mixed solution is the internal water phase;

[0053] The configuration of the intermediate oil phase fluid: the intermediate oil phase is made of soybean oil, benzyl benzoate and oil-soluble emulsifier, the volume ratio of soybean oil and benzyl benzoate is 4:1, the emulsifier and soybean oil and benzyl benzoate The mass ratio of the ester mixture is 0.020:1, and...

Embodiment 3

[0063] (1) Preparation of inner water phase, middle oil phase, outer water phase and collected water phase fluid

[0064] Preparation of the inner water phase fluid: the inner water phase fluid is made of sodium alginate, water-soluble emulsifier Pluronic F68 and deionized water, the mass ratio of sodium alginate to deionized water is 0.05:1, and the water-soluble emulsifier Pluronic F68 The mass ratio to deionized water is 0.010:1; sodium alginate and water-soluble emulsifier Pluronic F68 are added to deionized water at normal pressure and room temperature and stirred until completely dissolved, and the resulting mixed solution is the internal water phase;

[0065] The configuration of the intermediate oil phase fluid: the intermediate oil phase is made of soybean oil, benzyl benzoate and oil-soluble emulsifier, the volume ratio of soybean oil and benzyl benzoate is 2:3, the emulsifier is mixed with soybean oil and benzyl benzoate The mass ratio of the ester mixture is 0.040:...

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Abstract

The invention relates to a method for preparing mono-dispersity calcium alginate microspheres based on emulsion liquid membrane mass transfer. The method includes the steps of firstly, preparing inner water phase, middle oil phase, outer water phase and collecting water phase fluid; secondly, respectively injecting inner water phase, middle oil phase and outer water phase fluid into the injection tube, the transition tube and the collecting tube of a microfluid device to form mono-dispersity water / oil / water emulsion, guiding the water / oil / water emulsion into the collecting water phase fluid, standing for at least 2 hours, allowing Ca<2+> in collecting water phase to enter inner water phase through the oil membrane mass transfer of water / oil / water double emulsion so as to have cross-linking reaction with sodium alginate to generate the calcium alginate gel microspheres, and allowing water in inner water phase to enter collecting water phase through oil membrane mass transfer; thirdly, using filter paper to filter collecting water phase solution containing the calcium alginate microspheres, and washing with deionized water to obtain the mono-dispersity calcium alginate microspheres.

Description

technical field [0001] The invention belongs to the field of polymer microsphere preparation, and in particular relates to a method for preparing monodisperse calcium alginate microspheres based on emulsion liquid film mass transfer. Background technique [0002] Due to its wide range of sources, non-toxicity, excellent biocompatibility and biodegradability, and good water solubility, alginate has received extensive attention in the fields of biology and medicine, among which sodium alginate is the most common alginic acid Salt. Sodium alginate is a linear copolymer of β-D-mannuronic acid (M) and α-L-guluronic acid (G), and the residue of guluronic acid in its molecular chain can be easily Cross-linking reaction with divalent cations, such as sodium alginate and Ca 2+ Cross-linking produces calcium alginate gel. Due to its small size and large specific surface area, calcium alginate microspheres can be used as a carrier to carry a variety of active substances, including i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A61K9/16A61K47/36A61K47/32A61L31/04C08J3/12
CPCA61K9/1635A61K9/1652A61K9/1682A61L31/042A61L31/048A61L2430/36B01J13/02C08J3/12C08J2305/04C08L5/04C08L29/04
Inventor 牟川淋余亚兰戴一阳
Owner SOUTHWEST PETROLEUM UNIV
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