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Preparation method of dialdehyde cellulose cross-linked chitosan film

A technology of cross-linking chitosan and cellulose, which is applied in the field of preparation of dialdehyde cellulose cross-linked chitosan film, can solve the problems that there are no reports of dialdehyde cellulose cross-linked chitosan film, and achieve high mechanical The effect of strength, less pollution and simple preparation process

Inactive Publication Date: 2016-10-26
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Dialdehyde cellulose has been used in the preparation of cross-linked collagen membranes, etc., but there is no report on dialdehyde cellulose cross-linked chitosan membranes

Method used

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  • Preparation method of dialdehyde cellulose cross-linked chitosan film
  • Preparation method of dialdehyde cellulose cross-linked chitosan film
  • Preparation method of dialdehyde cellulose cross-linked chitosan film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Add 1 part of microcrystalline cellulose to 20 parts of 64% (w / v) concentrated sulfuric acid, mechanically stir at 45°C and 600r / min for 1h, centrifuge at 10000r / min at high speed, and collect the upper layer of white CNC colloid After 3 days of dialysis, add 0.1N sodium hydroxide solution to adjust the pH of the colloid to 6.5;

[0023] (2) Add 6.3 parts of sodium periodate to the CNC colloid prepared in step (1), react at 45°C for 4 hours in the dark; add 3 parts of ethylene glycol to react for 1 hour and dialyze for 5 days to obtain dialdehyde cellulose aqueous solution;

[0024] (3) under room temperature, adopt 1% ​​(v / w) acetic acid solution to prepare 1% (w / w) chitosan solution, 1 part of dialdehyde cellulose aqueous solution prepared by step (2) and 100 parts of 1% The chitosan solution was mixed, vacuum defoamed, cast in a polytetrafluoroethylene mold, and dried at room temperature to form a film.

Embodiment 2

[0026] (1) Add 1 part of microcrystalline cellulose to 20 parts of 64% (w / v) concentrated sulfuric acid, mechanically stir at 45°C and 600r / min for 1h, centrifuge at 10000r / min at high speed, and collect the upper layer of white CNC colloid After 3 days of dialysis, add 0.1N sodium hydroxide solution to adjust the pH of the colloid to 6.5;

[0027] (2) Add 6.3 parts of sodium periodate to the CNC colloid prepared in step (1), react at 45°C for 4 hours in the dark; add 3 parts of ethylene glycol to react for 1 hour and dialyze for 5 days to obtain dialdehyde cellulose aqueous solution;

[0028] (3) under room temperature, adopt 1% ​​(v / w) acetic acid solution to prepare 1% (w / w) chitosan solution, the dialdehyde cellulose aqueous solution prepared by 3 parts of steps (2) and 100 parts of 1% chitosan solution The chitosan solution was mixed, vacuum defoamed, cast in a polytetrafluoroethylene mold, and dried at room temperature to form a film.

Embodiment 3

[0030] (1) Add 1 part of microcrystalline cellulose to 20 parts of 64% (w / v) concentrated sulfuric acid, mechanically stir at 45°C and 600r / min for 1h, centrifuge at 10000r / min at high speed, and collect the upper layer of white CNC colloid After 3 days of dialysis, add 0.1N sodium hydroxide solution to adjust the pH of the colloid to 6.5;

[0031] (2) Add 6.3 parts of sodium periodate to the CNC colloid prepared in step (1), react at 45°C for 4 hours in the dark; add 3 parts of ethylene glycol to react for 1 hour and dialyze for 5 days to obtain dialdehyde cellulose aqueous solution;

[0032] (3) under room temperature, adopt 1% ​​(v / w) acetic acid solution to prepare 1% (w / w) chitosan solution, the dialdehyde cellulose aqueous solution prepared by 5 parts of steps (2) and 100 parts of 1% chitosan solution The chitosan solution was mixed, vacuum defoamed, cast in a polytetrafluoroethylene mold, and dried at room temperature to form a film.

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Abstract

The invention discloses a preparation method of a dialdehyde cellulose cross-linked chitosan film, and belongs to the field of natural macromolecule modification. Microcrystalline cellulose is used as raw materials; water-soluble dialdehyde cellulose is respectively prepared through concentrated sulfuric acid hydrolysis and sodium periodate selective oxidization; then, the dialdehyde cellulose water solution is directly mixed with chitosan-acetic acid solution; vacuum defoaming and room temperature casting drying film formation are performed. Compared with a pure chitosan film, the dialdehyde cellulose cross-linked chitosan film prepared by the method provided by the invention has the advantages that the mechanical performance is obviously improved; the swelling degree in the water is obviously reduced.

Description

technical field [0001] The invention relates to a preparation method of a dialdehyde cellulose cross-linked chitosan film, which belongs to the field of modification of natural polymers. Background technique [0002] Chitin widely exists in the shells of insects and crustaceans, as well as in the cell walls of some fungi. It is a biopolymer with reserves second only to cellulose in nature. Chitosan is a deacetylated derivative of chitin, which has good film-forming properties, biocompatibility, biodegradability, antibacterial, hemostatic and wound healing functions. At present, the application of chitosan film in food preservation, drug controlled release, hemodialysis and wound dressing is very attractive. However, the low wet strength limits the wide application of chitosan films in the fields of food packaging and biomedical materials. It has been reported that the mechanical strength of chitosan films can be significantly improved by chemical cross-linking methods. Ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08J3/24C08L5/08C08L1/08C08B15/00
CPCC08J5/18C08B15/00C08J3/24C08J2305/08C08J2401/08C08L5/08C08L2201/06C08L1/08
Inventor 田秀枝蒋学闫德东
Owner JIANGNAN UNIV
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