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Capsaicin ethosomes gel and preparation method thereof

The technology of capsaicin and alcohol body, applied in the field of beauty cosmetics, can solve the problems of strong irritation, poor transdermal absorption performance, etc., achieve no toxic side effects, avoid skin irritation and burns, good stability and transdermal absorption Effect

Active Publication Date: 2016-11-09
西安艾尔菲生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a capsaicin ethosome gel, which can be used for local weight loss, and solves the problems of poor transdermal absorption and strong irritation of the existing capsaicin external preparations

Method used

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  • Capsaicin ethosomes gel and preparation method thereof
  • Capsaicin ethosomes gel and preparation method thereof
  • Capsaicin ethosomes gel and preparation method thereof

Examples

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preparation example Construction

[0034] A preparation method of capsaicin ethosome gel, its technological process is as follows figure 1 As shown, the specific steps are as follows:

[0035] Step 1, weighing the following raw materials according to mass percentage: capsaicin 0.05%-0.15%, lecithin 0.50%-2.20%, vitamin E 0.06%-0.28%, stabilizer 0.20%-0.66%, absolute ethanol 2.30%- 11.10%, gelling agent 0.80%~1.40%, humectant 1.50%~6.00%, penetration enhancer 0.40%~1.40%, preservative 0.03%~0.23%, deionized water 75.00%~90.00%, the mass of the above components The sum of the percentages is 100%; wherein, the stabilizer is one or both of polysorbate-20, polysorbate-60, polysorbate-80, polyoxyethylene stearate, and phosphatidylglycerol ;Humectants are sodium pyrrolidone carboxylate, hyaluronic acid, sodium hyaluronate, sodium lactate, propylene glycol, 1,3-butanediol, hexylene glycol, xylitol, polypropylene glycol, sorbitol, polyethylene glycol, and amino acids One or two of them; the gelling agent is carrageena...

Embodiment 1

[0043] Step 1, weigh 4000mg of lecithin, 1000mg of vitamin E and 1000mg of capsaicin and dissolve them in 30ml of absolute ethanol, and stir at a speed of 800r / min for 10min in a water bath at 40°C to dissolve them completely. Alcoholic solution;

[0044] Step 2: Weigh 2000 mg of polysorbate-20 and 2000 mg of polysorbate-60, completely dissolve them in 300 ml of purified water, mix them evenly, and keep warm in a water bath at 40°C for 20 minutes to obtain an aqueous phase solution;

[0045] Step 3: Slowly inject the alcohol phase solution prepared in step 1 into the water phase solution prepared in step 2. At this time, the concentration of ethanol in the final mixed solution is 10%, and magnetic stirring is carried out in a water bath at 25 ° C. The stirring speed is 1500r / min, the time is 60min, obtains crude capsaicin ethosome suspension;

[0046] Step 4, the suspension obtained in step 3 is subjected to intermittent ultrasonic treatment for 3 times at room temperature, e...

Embodiment 2

[0052] Step 1, weigh 6000mg of lecithin, 750mg of vitamin E and 500mg of capsaicin and dissolve them in 50ml of absolute ethanol, and stir at a speed of 900r / min for 15min under a water bath condition of 50°C to make them completely dissolve. Alcoholic solution;

[0053] Step 2, weigh 2000mg of polysorbate-80, completely dissolve it into 200ml of phosphate buffer solution with pH=6.8, mix well, and keep it in a water bath at 50°C for 15min to obtain an aqueous phase solution;

[0054] Step 3: Slowly inject the alcohol phase solution prepared in step 1 into the water phase solution prepared in step 2. At this time, the ethanol concentration in the mixed solution is 25%, and magnetic stirring is carried out in a water bath at 37° C., and the stirring speed is 1300r / min, the time is 45min, obtains crude capsaicin ethosome suspension;

[0055] Step 4, the suspension obtained in step 3 is subjected to intermittent ultrasonic treatment for 3 times at room temperature, each time fo...

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Abstract

The invention discloses a capsaicin ethosomes gel, which can be used for local weight loss. The particle size of capsaicin ethosomes in the gel is 100-160nm, and the encapsulation rate is greater than 85%. The invention further discloses a preparation method of the gel. The preparation method specifically comprises the following steps: preparing rough capsaicin ethosomes suspension, then carrying out ultrasonic high-pressure homogenization, and filtering to obtain fine capsaicin ethosomes; evenly mixing a gelatinizer, a moisturizing agent, a penetration promoter, a preservative and deionized water to obtain a gel body; and then evenly mixing capsaicin ethosomes with the gel body to obtain the gel. By wrapping capsaicin with ethosomes, the gel has better stability and transdermal absorption property; the prepared capsaicin ethosomes gel is an external transdermal delivery agent, and can enhance the transdermal penetration effect while reducing the irritation to the skin; and the gel contains the penetration promoter of a certain composition, so that the transdermal penetration effect of the capsaicin ethosomes gel can be further enhanced.

Description

technical field [0001] The invention belongs to the technical field of beauty cosmetics, and in particular relates to a capsaicin ethosome gel, and also relates to a preparation method of the ethosome gel. Background technique [0002] Partial obesity refers to the obesity that occurs due to excessive fat accumulation in a certain part of the body. The abdomen, buttocks, and thighs are the most common. Hovering in the range between obesity and overweight levels. For this group, local weight loss is very important. [0003] Capsaicin is the main chemical substance that causes the pepper to be pungent, and is also the main substance to control obesity. The content in the pepper fruit is only between 0.2% and 1.0%. In recent years, a large number of human and animal experiments at home and abroad have proved that capsaicin has a good weight loss effect. Joo et al. added capsaicin (10mg / kg BW) to the high-fat diet of rats, and found that compared with the placebo group, the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K47/36A61K47/10A61K47/38A61K47/32A61K31/165A61P3/04
CPCA61K9/0014A61K9/06A61K9/1271A61K31/165A61K47/10A61K47/32A61K47/36A61K47/38
Inventor 胡春梅刘艳赵文静王静
Owner 西安艾尔菲生物科技有限公司
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