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Medical dressing and preparation method thereof

A medical, acid-method gelatin technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of increased toxicity, brittleness, and low mechanical strength of hydrogels in the gel system, achieve good barrier effect, and reduce the incidence rate , the effect of low cost

Active Publication Date: 2016-11-09
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogels currently used are basically made by one of chemical cross-linking, radiation cross-linking and physical cross-linking. The hydrogel synthesized by a single method contains a large amount of water to increase the molecular chain length between cross-linking points. Factors such as too wide distribution lead to low mechanical strength of the hydrogel and are very brittle, and chemical cross-linking inevitably introduces cross-linking agents, initiators, and organic solvents during the synthesis process, which will increase the toxicity of the gel system

Method used

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  • Medical dressing and preparation method thereof
  • Medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as figure 1 As shown, the medical dressing of the present invention is made of non-woven fabric 3 (preferably medical non-woven fabric), and a waterproof and moisture-permeable layer 2 is sprayed on the front direction of the non-woven fabric 3, and the waterproof and moisture-permeable layer 2 is made of polyurethane At the same time, the pore size in the polyurethane nanofiber membrane is controlled between 0.2 and 1 μm (preferably 0.5 μm), because the pore size is too large, the waterproof ability of the polyurethane nanofiber membrane and the ability to block particles such as bacteria will decline, while If the pore size is too small, it is not conducive to the moisture permeability of the dressing. The pore size of the polyurethane nanofiber membrane is between 0.2 and 1 μm, which ensures a good barrier effect on bacteria and has a good air permeability effect. The surface of the waterproof and moisture-permeable layer 2 is coated with gelatin nanoparticles 1...

Embodiment 2

[0050] The present embodiment provides the preparation method of this medical dressing, and concrete preparation steps are as follows:

[0051] 1) Polyurethane nanofibers are prepared by thermoplastic nanofiber preparation technology, and the average diameter of polyurethane nanofibers is controlled between 200 and 500nm. The average diameter of polyurethane nanofibers prepared in this implementation is 250nm; , the polyurethane nanofiber suspension was obtained, and the mass concentration percentage of the polyurethane nanofiber suspension was controlled at 20 to 35%, and the mass concentration percentage of the polyurethane nanofiber suspension prepared in this embodiment was 21.6%;

[0052] In order to prepare the nanofiber membrane, the polyurethane nanofiber suspension with a mass concentration of 21.6% is evenly sprayed on the front of the medical non-woven fabric, and then dried with hot air to prepare a medical non-woven fabric composited with the polyurethane nanofiber...

Embodiment 3

[0058] The present embodiment provides the preparation method of this medical dressing, and concrete preparation steps are as follows:

[0059] 1) Polyurethane nanofibers are prepared by thermoplastic nanofiber preparation technology, and the average diameter of polyurethane nanofibers is controlled between 200 and 500nm. The average diameter of polyurethane nanofibers prepared in this implementation is 400nm; , the polyurethane nanofiber suspension is obtained, and the mass concentration percentage of the polyurethane nanofiber suspension is controlled at 20 to 35%, and the mass concentration percentage of the polyurethane nanofiber suspension prepared in this implementation is 25.8%;

[0060] In order to prepare the nanofiber membrane, the polyurethane nanofiber suspension with a mass concentration of 25.8% is evenly sprayed on the front of the medical non-woven fabric, and then dried with hot air to prepare a medical non-woven fabric compounded with polyurethane nanofibers. ...

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Abstract

The invention discloses a medical dressing and a preparation method of the medical dressing, belonging to the field of medical dressing materials. The medical dressing is made of a non-woven fabric, a waterproof and moisture permeable layer is sprayed to the front side of the non-woven fabric, the waterproof and moisture permeable layer is prepared by a polyurethane nanofiber membrane, the surface of the polyurethane nanofiber membrane is coated with gelatin nano particles, and an antibacterial agent is loaded in the gelatin nano particles; meanwhile, a waterproof layer is sprayed to the back side of the non-woven fabric. The preparation method of the medical dressing comprises the following steps: (1) preparing the non-woven fabric compounded with the polyurethane nanofiber membrane; (2) preparing the polyvinylidene fluoride waterproof layer; (3) preparing gelatin nano particle freeze-dried powder; (4) preparing a gelatin nano particle suspension loaded with the antibacterial agent; and (5) coating the surface of the polyurethane nanofiber membrane with the gelatin nano particle suspension loaded with the antibacterial agent, thus preparing the target product. The medical dressing has water-proofing and moisture-permeating capacities, and also can release the antibacterial agent intelligently, so that the drug resistance of bacteria is reduced.

Description

technical field [0001] The invention belongs to the field of medical dressing materials, and in particular relates to a medical dressing and a preparation method thereof. Background technique [0002] Gelatin is a kind of hydrolyzate derived from collagen in animal connective tissue. It has good biocompatibility, biodegradability, non-immune antigenicity and excellent viscosity, gelling, film-forming properties, etc., and is widely used In the food, cosmetic and pharmaceutical industries. Gelatin nanoparticles can be used to adsorb or embed various drugs with different properties (such as antineoplastic drugs paclitaxel and doxorubicin, etc.) or inorganic particles (such as gold, iron oxide, etc.). [0003] Medical dressings are a class of important medical materials used to cover sores, wounds or other injuries. They can replace damaged skin to act as a temporary barrier, avoid or control wound infection, and provide an environment conducive to wound healing. The dressing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/26A61L15/24A61L15/42A61L15/44A61L15/52
CPCA61L15/24A61L15/26A61L15/32A61L15/42A61L15/46A61L15/52A61L2300/252A61L2300/404C08L75/04C08L27/16
Inventor 鲁振坦王栋张佳琪王小俊王雯雯王跃丹赵清华
Owner WUHAN TEXTILE UNIV
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