Composition capable of forming composite bone cement and bone cement formed by same

Abstract

The invention provides a composition capable of forming composite bone cement and the bone cement formed by the same. The composition contains a composition forming polymethyl methacrylate bone cement and tuna fish bone meal / hyaluronic acid microspheres. The composition contains, by 100% total weight, the tuna fish bone meal / hyaluronic acid microspheres accounting for the mass fraction of 8%-60%. The microspheres are prepared from tuna fish bone meal and hyaluronic acid as raw materials, and by the 100% total weight of the tuna fish bone meal and hyaluronic acid, the mass fraction of the tuna fish bone meal accounts for 30%-70%, and the mass fraction of the hyaluronic acid accounts for 30%-70%. The tuna fish bone meal / hyaluronic acid microspheres promoting bone growth are added in the composition on the basis that the composition can form a PMMA bone cement composition, and the obtained bone cement has the advantages of excellent biological activity, biocompatibility, bone integration performance and the like.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composition capable of forming composite bone cement and the bone cement formed therefrom. Background technique [0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of powder and liquid phase. It can be cured by mixing it in a certain proportion at room temperature, and it can be placed on the replacement joint or filling site After the reaction is over, the joint can be fixed or the bone defect can be repaired. Due to the injectability of bone cement, it can minimize the area of ​​minor surgical wounds, speed up the recovery, and reduce the pain of patients. Therefore, it is often used as a filling material and scaffold material for bone tissue, which plays a supporting role and is an indispensable material for bone tissue applications. a member of Since the advent of bone cement in the early 1960s, the main ...

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Problems solved by technology

Although the traditional polymethyl methacrylate (PMMA) bone cement has good mechanical properties, it can be used for bone repair implants in the load-bearing part, and it has a strong bonding force with implant materials, but it cannot directly Induce the growth of bone tissue, the interface binding force with the host bone is low, easy to loose, and the excessive heat accumulation temperature is formed during curing, which may easily cause damage to surrounding tissues and spinal cord, etc.

The above defects limit the application range of PMMA bone cement as a filling material for the treatment of osteoporosis

Moreover, after curing, the matrix of PMMA material is relatively dense, and there are no pores on the surface, which is not conducive to the growth of tissues, and the osseointegration performance is poor.

Therefore, how to improve the PMMA bone cement so that it not only retains its excellent mechanical properties, but also can promote the growth of bone tissue and increase the bonding force with the host bone cells; reduce the maximum curing temperature in its curing process; and / Or improve the PMMA material without pores, which is not conducive to the defects of tissue growth is an important research topic in this field

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