Composition capable of forming composite bone cement and bone cement formed by same

A composition and bone cement technology, which can be used in drug delivery, tissue regeneration, prostheses, etc., and can solve problems such as injury, surrounding tissue spinal cord, and lower maximum curing temperature

Active Publication Date: 2016-11-23
SHENZHEN INST OF ADVANCED TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional polymethyl methacrylate (PMMA) bone cement has good mechanical properties, it can be used for bone repair implants in the load-bearing part, and it has a strong bonding force with implant materials, but it cannot directly Induce the growth of bone tissue, the interface binding force with the host bone is low, easy to loose, and the excessive heat accumulation temperature is formed during curing, which may easily cause damage to surrounding tissues and spinal cord, etc.
The above defects limit the application range of PMMA bone cement as a filling material for the treatment of osteoporosis
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Method used

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  • Composition capable of forming composite bone cement and bone cement formed by same
  • Composition capable of forming composite bone cement and bone cement formed by same
  • Composition capable of forming composite bone cement and bone cement formed by same

Examples

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Embodiment 1

[0101] This embodiment provides a composition capable of forming a composite bone cement and the bone cement formed therefrom, specifically, it can be embodied in the following method for preparing a composite bone cement or its slurry, and the method includes the following steps:

[0102] Select the polymethyl methacrylate (PMMA) powder with a particle size of 40-60 μm prepared by the aforementioned method, and see the microscopic morphology and particle size of the PMMA powder. figure 2 . Select natural tuna fish bone powder / hyaluronic acid microspheres prepared by the aforementioned method, wherein the mass percentage of tuna fish bone powder is 60%, the particle size is about 150 μm, and its microscopic appearance is shown in image 3 shown. The above-mentioned natural tuna fish bone powder / hyaluronic acid microspheres and PMMA powder, polymerization initiator dibenzoyl peroxide (BPO) are mixed according to the mass ratio of 30%: 68%: 2%, and obtained after disinfection ...

Embodiment 2

[0120] This embodiment provides a composition that can be formed and a bone cement formed therefrom. Specifically, it can be embodied in the following method for preparing a composite bone cement or its slurry. The method includes the following steps:

[0121] (1) Preparation of solid phase powder:

[0122] Select the polymethyl methacrylate (PMMA) powder with a particle size of 60-80 μm and the tuna fish bone powder / hyaluronic acid microspheres with a particle size of 40-80 μm prepared by the aforementioned method. Mix PMMA, tuna fish bone meal / hyaluronic acid microspheres and polymerization initiator dibenzoyl peroxide (BPO) according to the mass ratio of 60%:39%:1%, and obtain the solid phase of composite bone cement after disinfection powder;

[0123] (2) Preparation of solidified liquid:

[0124] Mix N,N-dimethyl-p-toluidine (DMPT) and liquid methyl methacrylate (MMA) uniformly according to the mass percentage of 1.5%:98.5% to prepare a solidified solution of composite ...

Embodiment 3

[0131] This embodiment provides a composition capable of forming a composite bone cement and the bone cement formed therefrom, specifically, it can be embodied in the following method for preparing a composite bone cement or its slurry, and the method includes the following steps:

[0132] (1) Preparation of solid phase powder:

[0133] Select polymethyl methacrylate (PMMA) powder with a particle size of 60-80 μm prepared by the aforementioned method, tuna fish bone powder / hyaluronic acid microspheres with a particle size of 100-200 μm and polymerization initiator diphenyl peroxide Formyl (BPO), mixed according to the mass ratio of 5%: 93.5%: 1.5%, is sterilized to obtain the solid-phase powder of composite bone cement;

[0134] (2) Preparation of solidified liquid:

[0135] Mix N,N-dimethyl-p-toluidine (DMPT) and methyl methacrylate (MMA) uniformly according to the mass percentage of 3%:97%, and prepare the solidifying solution of the composite bone cement;

[0136] (3) Pre...

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Abstract

The invention provides a composition capable of forming composite bone cement and the bone cement formed by the same. The composition contains a composition forming polymethyl methacrylate bone cement and tuna fish bone meal/hyaluronic acid microspheres. The composition contains, by 100% total weight, the tuna fish bone meal/hyaluronic acid microspheres accounting for the mass fraction of 8%-60%. The microspheres are prepared from tuna fish bone meal and hyaluronic acid as raw materials, and by the 100% total weight of the tuna fish bone meal and hyaluronic acid, the mass fraction of the tuna fish bone meal accounts for 30%-70%, and the mass fraction of the hyaluronic acid accounts for 30%-70%. The tuna fish bone meal/hyaluronic acid microspheres promoting bone growth are added in the composition on the basis that the composition can form a PMMA bone cement composition, and the obtained bone cement has the advantages of excellent biological activity, biocompatibility, bone integration performance and the like.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composition capable of forming composite bone cement and the bone cement formed therefrom. Background technique [0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of powder and liquid phase. It can be cured by mixing it in a certain proportion at room temperature, and it can be placed on the replacement joint or filling site After the reaction is over, the joint can be fixed or the bone defect can be repaired. Due to the injectability of bone cement, it can minimize the area of ​​minor surgical wounds, speed up the recovery, and reduce the pain of patients. Therefore, it is often used as a filling material and scaffold material for bone tissue, which plays a supporting role and is an indispensable material for bone tissue applications. a member of Since the advent of bone cement in the early 1960s, the main ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50A61L27/54
CPCA61L27/44A61L27/50A61L27/54A61L2400/06A61L2430/02A61L2300/30A61L2300/412C08L33/12C08L5/08
Inventor 崔旭黄程程张朦潘浩波阮长顺王践云彭松林
Owner SHENZHEN INST OF ADVANCED TECH
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