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Preparation method of LDL (low density lipoprotein) adsorbent

A low-density lipoprotein and adsorbent technology, applied in the field of polymers, can solve problems such as no research reports on phosphoric acid adsorbents, and achieve good removal effect, convenient storage, and good mechanical strength.

Active Publication Date: 2016-11-23
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the affinity-type low-density lipoprotein (LDL) adsorbent, the affinity groups used are mainly anions, with sulfonic acid as the most, followed by carboxylic acid. There is no research report on the adsorbent with phosphoric acid as ligand.

Method used

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  • Preparation method of LDL (low density lipoprotein) adsorbent

Examples

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Comparison scheme
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Embodiment 1

[0024] 1. Preparation of Porous Epoxy Resin

[0025] Prepare 1 L of an aqueous solution containing 10 g / L of polyvinyl alcohol and 20 g / L of gelatin as the aqueous phase solution of the epoxy resin reaction system prepared by suspension polymerization. Dissolve 120 mg of benzoyl peroxide in a mixed solution containing 12 mL of glycidyl methacrylate, 3 mL of trimethylolpropane trimethacrylate and 18 mL of n-heptane, and add the oily mixed solution to 60 mL of the aqueous phase solution In the process, the obtained oil-water two-phase layered mixed system was stirred at room temperature with a mechanical stirring speed of 300r.p.m. for 1 hour, then the temperature was raised to 80°C, and the polymerization reaction was carried out for 20 hours, and the obtained product epoxy resin was used successively After washing with acetone and ethanol three times, vacuum-dry at 60°C for 12 hours before use.

[0026] 2. Preparation of LDL Adsorbent Resin

[0027] Add 100mL of ethylenediam...

Embodiment 2

[0030] 1. Preparation of Porous Epoxy Resin

[0031] Prepare 1L of aqueous solution containing polyvinyl alcohol as 8g / L and gelatin as 12g / L to prepare the aqueous phase solution of the epoxy resin reaction system by suspension polymerization. 120 mg of benzoyl peroxide was dissolved in a mixed solution containing 12 mL of glycidyl methacrylate, 3 mL of trimethylolpropane trimethacrylate and 18 mL of n-hexane, and the oily mixed solution was added to 60 mL of aqueous solution to obtain The oil-water two-phase layered mixed system was stirred at room temperature with a mechanical stirring speed of 300r.p.m. for 1 hour, then the temperature was raised to 80°C, and the polymerization reaction was carried out for 20 hours. The obtained product epoxy resin was successively washed with acetone and ethanol After washing three times, vacuum-dry at 60°C for 12 hours before use.

[0032] 2. Preparation of LDL Adsorbent Resin

[0033] Add 150mL of ethylenediamine into 10g of epoxy res...

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Abstract

The invention belongs to the field of polymers, and particularly relates to a preparation method of an LDL (low density lipoprotein) adsorbent. The LDL adsorbent comprises a polymer carrier serving as a substrate and phosphate groups covalently bonded to the carrier surface, and is prepared as follows: porous epoxy resin with the particle size ranging from 100 mu m to 500 mu m is prepared with a suspension polymerization method and then mixed with anhydrous ethylenediamine, the mixture is heated and stirred, amino resin is obtained and mixed with formaldehyde, phosphorous acid and hydrochloric acid, the mixture is heated and reacts, and the LDL adsorbent is obtained. Polymer microspheres adsorbed by the LDL adsorbent have good removal effect on IgG pathogenic factors.

Description

technical field [0001] The invention belongs to the field of macromolecules, and in particular relates to a preparation method of a low-density lipoprotein adsorbent. Background technique [0002] Polymer adsorption materials refer to porous, highly cross-linked polymer adsorption resins, which have large specific surface area and appropriate pore size, and have selective affinity for certain ions or molecules. Become one of the important organic functional materials. There are many ways to prepare polymer microspheres. The classic methods include suspension polymerization, dispersion polymerization, emulsion polymerization, precipitation polymerization, etc. The diameter, pore size distribution and specific surface area of ​​microspheres prepared by various methods There are differences in the dispersion of microsphere diameters. [0003] Hypercholesterolemia (hypercholesterolemia) is an important factor causing arteriosclerosis, coronary heart disease and myocardial infa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C08G59/14
Inventor 邹汉法董靖欧俊杰
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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