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Traditional Chinese medicine suppository for treating cervical disease of high risk type HPV persistent infection and preparation method thereof

A persistent infection and suppository technology, applied in the direction of diseases, antiviral agents, suppository delivery, etc., can solve the problems that are not conducive to oral administration, achieve the effects of wide distribution of drugs, reduce local cervical coloration, and no vaginal bleeding

Active Publication Date: 2016-12-07
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4) Most of the traditional Chinese medicines are bitter and astringent, which is not conducive to oral administration. 5) The process is simple, easy to scale up and industrialized production

Method used

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  • Traditional Chinese medicine suppository for treating cervical disease of high risk type HPV persistent infection and preparation method thereof
  • Traditional Chinese medicine suppository for treating cervical disease of high risk type HPV persistent infection and preparation method thereof
  • Traditional Chinese medicine suppository for treating cervical disease of high risk type HPV persistent infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of the Chinese medicine suppository provided by embodiment 1 present invention

[0027] prescription:

[0028]

[0029] Preparation method: Take the realgar, Coptis chinensis, alum, and borneol that have been passed through a 100-mesh sieve, mix them evenly, and pour them into molten mixed fatty acid glycerides (2670g). Mix evenly and pour into the mixed fatty acid glyceride base heated to 40°C to melt. The drug-containing suspension solution uniformly dispersed after stirring is poured into the plug shell, and sealed after cooling to obtain 2000 plugs, and the weight of a single plug is 1.5 g.

[0030] Treatment method: once a day, one tablet at a time, avoiding menstrual period, continuous medication (according to the degree of lesion) for one to three months.

Embodiment 2

[0031] Embodiment 2 The preparation of the Chinese medicine suppository provided by the present invention

[0032] prescription:

[0033]

[0034] Preparation method: Take realgar, berberine hydrochloride, alum, and borneol that have been passed through a 100-mesh sieve in the prescribed amount, mix them evenly and pour them into molten mixed fatty acid glycerides (1170g). Mix evenly and pour into the mixed fatty acid glyceride base heated to 40°C to melt. The drug-containing suspension solution uniformly dispersed after stirring is poured into the plug shell, sealed after cooling to obtain 1000 plugs, and the weight of a single plug is 1.5 g.

[0035] Treatment method: once a day, one tablet at a time, avoiding menstrual period, continuous medication (according to the degree of lesion) for one to three months.

Embodiment 3

[0036] Embodiment 3 The preparation of Chinese medicine suppository provided by the present invention

[0037] prescription:

[0038]

[0039]

[0040] Preparation method: Take realgar, berberine hydrochloride, alum, and borneol that have been passed through a 100-mesh sieve in the prescribed amount, mix them evenly and pour them into molten mixed fatty acid glycerides (920g). Mix evenly and pour into the mixed fatty acid glyceride base heated to 40°C to melt. The drug-containing suspension solution uniformly dispersed after stirring is poured into the plug shell, sealed after cooling to obtain 1000 plugs, and the weight of a single plug is 1.5 g.

[0041] Treatment method: once a day, one tablet at a time, avoiding menstrual period, continuous medication (according to the degree of lesion) for one to three months.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine suppository for treating a cervical disease of high risk type HPV persistent infection and a preparation method thereof. The traditional Chinese medicine suppository comprises a host and a pharmaceutically acceptable adjuvant made into the suppository; the host is prepared from, by weight, 50-150 parts of realgar, 100-300 parts of coptidis rhizoma or berberine hydrochloride, 10-30 parts of alum and 5-15 parts of borneol. The preparation method comprises the steps that formulated amount of realgar, coptidis rhizoma or berberine hydrochloride, alum and borneol which are screened with a 100-mesh sieve are taken, mixed to be uniform and then added into a fused mixed fatty acid glyceride substrate of 39 DEG C to 41 DEG C, a medicine-containing suspension solution which is uniformly dispersed after stirring is conducted is poured into a suppository shell, cooling and sealing are conducted in sequence, and the traditional Chinese medicine suppository is obtained. According to the traditional Chinese medicine suppository, the particle sizes of the medicines in the suppository are greatly decreased, the medicines can enter tissue by penetrating through mucosa easily, the absorption rate of the medicines and bioavailability are greatly decreased, and the pharmacological action of the main effective ingredients is significantly higher than that of a traditional preparation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine suppository for treating cervical diseases caused by persistent high-risk HPV infection and a preparation method thereof. Background technique [0002] Cervical cancer is the malignant tumor with the most definite etiology so far, and high-risk human papillomavirus (HR-HPV) is recognized as the main pathogenic factor of cervical cancer. The latent and persistent infection of HPV in the host cervical epithelial cells is the prerequisite for HPV carcinogenesis. The viral oncogene E6 / E7 is continuously expressed in the HPV-transformed cervical epithelium, which induces and maintains the malignant phenotype of cells, which is the key to the occurrence and development of cervical cancer. The key factor. A large amount of evidence shows that the process from HPV infection to cervical cancer is a gradual and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K33/36A61K9/02A61P31/20A61P15/00A61K33/06A61K31/4375A61K31/045
CPCA61K9/0034A61K9/02A61K31/045A61K31/4375A61K33/06A61K33/36A61K36/718A61K47/14A61K2300/00
Inventor 刘嵘濮德敏
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH