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Method for preparing O-carboxymethyl chitosan covered nano-silver

A technology of carboxymethyl chitosan and nano-silver, which is applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of nano-silver easy to agglomerate, poor dispersion, and human health hazards. Achieve good dispersibility and stability, easy operation, and healthy effects

Inactive Publication Date: 2016-12-14
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a method for preparing O-carboxymethyl chitosan-wrapped nano-silver. The method uses O-carboxymethyl chitosan as a stabilizer and reducing agent, and silver is reduced under ultraviolet light to obtain a composite antibacterial agent , with good and safe antibacterial properties, to solve the potential harm to human health caused by the use of toxic chemical reagents in the preparation process of existing nano-silver antibacterial agents, as well as the problems of easy agglomeration and poor dispersion of nano-silver

Method used

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  • Method for preparing O-carboxymethyl chitosan covered nano-silver
  • Method for preparing O-carboxymethyl chitosan covered nano-silver
  • Method for preparing O-carboxymethyl chitosan covered nano-silver

Examples

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Embodiment 1

[0029] (1) 0.1g silver nitrate was dissolved in 100ml ultrapure water, 0.1g O-carboxymethyl chitosan was dissolved in 100ml ultrapure water, mixed at a volume ratio of 5:95, and magnetically stirred for 0.5h;

[0030] (2) Take 3mL of the mixed solution and put it in a 4mL quartz cuvette, ventilate nitrogen for 20s to exhaust the air and then seal it, place the sample bottle at a distance of 5cm from a 272nm UV lamp and irradiate it for 130min with the power of the UV lamp at 20w;

[0031] (3) After the ultraviolet lamp irradiation, the mixed solution in the quartz cuvette turned golden yellow, and one volume of absolute ethanol was added to the mixed solution, and the precipitate was centrifuged at 14000r / min for 60min, and the two cuvettes were centrifugally washed with 50%wt ethanol. Second-rate;

[0032] (5) Freeze-dry the precipitate to obtain O-carboxymethyl chitosan-coated nano-silver composite antibacterial agent powder.

[0033] (6) O-carboxymethyl chitosan-coated nan...

Embodiment 2

[0040] According to the processing method of embodiment 1, the difference of embodiment 2 is: the ultraviolet irradiation time is 70min. After ultraviolet irradiation, the mixed solution was light yellow, and the ultraviolet absorption peak of nano silver was lower than that of Example 1 in the ultraviolet-visible light spectrum test. Compared with Example 1, Example 2 reduces the UV irradiation time to obtain nano-silver with smaller size, more stability and lighter color, which is beneficial for further application, but the yield of nano-silver is not high, resulting in an increase in cost.

Embodiment 3

[0042] According to the process of Example 1, the difference of Example 4 is that the container used for ultraviolet irradiation is a glass sample bottle. Glassware is cheaper and easier to obtain than quartz vessels, which can effectively reduce the cost, but the light transmittance of quartz cuvettes is higher than that of glass bottles. Under the same irradiation time, the UV absorption peak of the sample using glass sample bottles in this embodiment is far lower than that in the embodiment. 1. The yield of nano-silver is low.

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Abstract

The invention discloses a method for preparing O-carboxymethyl chitosan covered nano-silver. According to the method, after silver nitrate solutions and O-carboxymethyl chitosan solutions are mixed according to a ratio, O-carboxymethyl chitosan covered nano-silver antibacterial agents are prepared through ultraviolet irradiation; the nano-silver serves as a main antibacterial ingredient, O-carboxymethyl chitosan serve as an auxiliary antibacterial ingredient, a reducing agent and a stabilizer, the toxicity of the antibacterial agents is lowered, Ag ions are reduced to elemental silver by the O-carboxymethyl chitosan on the condition of ultraviolet irradiation, and the O-carboxymethyl chitosan is adsorbed on the surface of a silver core to prevent aggregation of the nano-silver and realizes the synergistic antibacterial effect; and during detection, the minimal inhibitory concentration of the antibacterial agents to escherichia coli is 1 micro / milliliter and to staphylococcus aureus is 2 micro / milliliter and reaches the minimum concentration limit of the best similar products at home and abroad, the used materials are harmless to the human body, the price is low, and therefore the antibacterial agents are friendly to environment.

Description

technical field [0001] The invention relates to a preparation method of a composite antibacterial agent, in particular to a preparation method of a chitosan-nanometer silver composite antibacterial agent for blending or surface modification. Background technique [0002] Chitosan is a green natural antibacterial agent, because chitosan molecular structure contains a large number of active groups such as hydroxyl and amino groups, these groups can react with metal ions. The existing antibacterial preparation of chitosan with antibacterial properties usually adopts Ag as the main antibacterial substance. [0003] Nanosilver is one of the most promising nanomaterials, which has significantly better bactericidal properties than silver ion compounds. In recent years, industry and academia have carried out extensive exploration and development in the preparation and application of chitosan-nano silver composite antibacterial agents. [0004] The published invention patent of "a ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/02B82Y40/00B82Y30/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/07B22F1/16
Inventor 魏丽乔高宇端管路遥王斌马森源
Owner TAIYUAN UNIV OF TECH
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