Method for preparing high-strength and high-toughness poly-ion hydrogel support through 3D printing

A 3D printing, high-toughness polymer technology, applied in medical science, prosthesis, additive processing, etc., can solve problems such as insufficient breaking strength, loss of toughness, and failure to reach high-strength hydrogels, and achieves simple preparation methods, Effect of improving mechanical strength and good mechanical properties

Active Publication Date: 2017-01-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fracture strength of the structure is less than 500kPa, which cannot meet the requirements of high-strength hydrogels.
Although the system can obtain a fracture strength of more than 1MPa after crosslinking, it loses most of its toughness, and strength and toughness cannot be achieved at the same time.

Method used

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  • Method for preparing high-strength and high-toughness poly-ion hydrogel support through 3D printing
  • Method for preparing high-strength and high-toughness poly-ion hydrogel support through 3D printing
  • Method for preparing high-strength and high-toughness poly-ion hydrogel support through 3D printing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) N, N, N-trimethyl-3-(2-methacryloylamino)-1-propylammonium chloride (MPTC) and sodium p-styrenesulfonate ( NaSS) solution placed at a wavelength of 365nm and a power of 7.5mW / cm 2 Irradiate under the ultraviolet lamp for 8 hours to obtain the solution of two kinds of polymers. After purification by ethanol precipitation, oven drying and grinding, poly-N,N,N-trimethyl-3-(2-methacrylamino) - 1-propylammonium chloride (PMPTC) and polysodium p-styrene sulfonate (PNaSS) powder;

[0051] N, N, N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride solution concentration is 1mol / L, p-styrene sodium sulfonate solution concentration is 1mol / L, light The initiator is α-pentanonedioic acid, and the addition amount of the photoinitiator is 0.05mol% (relative to the concentration of the monomer);

[0052] (2) Poly-N,N,N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride is calculated as ammonium ion, polysodium p-styrenesulfonate is calculated as sulfonate ion Acc...

Embodiment 2

[0062] (1) N, N, N-trimethyl-3-(2-methacryloylamino)-1-propylammonium chloride (MPTC) and sodium p-styrenesulfonate ( NaSS) solution placed at a wavelength of 365nm and a power of 7.5mW / cm 2 Irradiate under the ultraviolet lamp for 8 hours to obtain the solution of two kinds of polymers. After purification by ethanol precipitation, oven drying and grinding, poly-N,N,N-trimethyl-3-(2-methacrylamino) - 1-propylammonium chloride (PMPTC) and polysodium p-styrene sulfonate (PNaSS) powder;

[0063] N, N, N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride solution concentration is 1mol / L, p-styrene sodium sulfonate solution concentration is 1mol / L, light The initiator is α-pentanonedioic acid, and the addition amount of the photoinitiator is 0.05mol%;

[0064] (2) Poly-N,N,N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride is calculated as ammonium ion, polysodium p-styrenesulfonate is calculated as sulfonate ion According to the calculation, poly-N,N,N-trimethyl...

Embodiment 3

[0073] (1) N, N, N-trimethyl-3-(2-methacryloylamino)-1-propylammonium chloride (MPTC) and sodium p-styrenesulfonate ( NaSS) solution placed at a wavelength of 365nm and a power of 7.5mW / cm 2 Irradiate under the ultraviolet lamp for 8 hours to obtain the solution of two kinds of polymers. After purification by ethanol precipitation, oven drying and grinding, poly-N,N,N-trimethyl-3-(2-methacrylamino) - 1-propylammonium chloride (PMPTC) and polysodium p-styrene sulfonate (PNaSS) powder;

[0074] N, N, N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride solution concentration is 1mol / L, p-styrene sodium sulfonate solution concentration is 1mol / L, light The initiator is α-pentanonedioic acid, and the addition amount of the photoinitiator is 0.05mol%;

[0075] (2) Poly-N,N,N-trimethyl-3-(2-methacrylamino)-1-propyl ammonium chloride is calculated as ammonium ion, polysodium p-styrenesulfonate is calculated as sulfonate ion According to the calculation, poly-N,N,N-trimethyl...

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Abstract

The invention discloses a method for preparing a high-strength and high-toughness poly-ion hydrogel support through 3D printing. The method includes the steps that an N,N,N-trimethyl-3-(2-methyl allyl acylamino)-1-propyl ammonia chloride solution to which a photoinitiator is added and a sodium p-styrenesulfonate solution are put below an ultraviolet lamp to be irradiated, solutions of two polymers are obtained, and two kinds of polymer powder are obtained after purifying, drying and grinding are completed; the two kinds of polymer powder are prepared into a water solution, the water solution is mixed and stirred, polyion compound precipitates are obtained, collected and dried, and polyion compound powder is obtained; saline is added into the polyion compound powder, the materials are stirred to be uniform, and polyion gel is obtained; a 3D printer is used for extruding the polyion gel in pure water under set printing parameters, and the poly-ion gel support is obtained after soaking and cross-linking forming. According to the method, bio-supports with different micro-structures and macro-appearances can be printed by correcting the printing parameters while it is guaranteed that the support has good mechanical performance.

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a method for preparing a high-strength and high-toughness polyion hydrogel scaffold by 3D printing. Background technique [0002] In the field of biomedicine, the transplantation and repair of organs and tissues has a wide range of needs and application markets. However, traditional organ or tissue transplantation and repair often face problems such as donor shortage, accompanying pathogen transmission, immune response, etc., which severely limit its application and development. [0003] In the field of tissue engineering, hydrogels have attracted extensive attention of researchers due to their similar properties to biological tissues. Using hydrogel as a bio-scaffold for cell culture and ultimately obtaining a substitute for the original diseased organ or tissue is considered to be an ideal solution to the above problems. The mechanical properties of natur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/16A61L27/50B33Y10/00
CPCA61L27/16A61L27/50A61L27/52B33Y10/00C08L25/18C08L33/24
Inventor 尹俊吴子良成利波朱凤博钱劲
Owner ZHEJIANG UNIV
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