Dipeptide hydrogel, and preparation method and application thereof

A hydrogel, selected technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve simple preparation methods, good self-healing properties, and good shear thinning properties Effect

Active Publication Date: 2017-01-18
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN 101831272 A discloses various organogels and hydrogels formed by dipeptide derivative small molecule organogels and their preparation methods. These amphiphilic dipeptide materials have many unique properties, such as their simple structure and easy Synthesis and analysis, easy modification, good biocompatibility, biodegradability, etc. The formed hydrogel has good mechanical properties and stimulus response properties, but the hydrogel cannot respond to ultrasound

Method used

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  • Dipeptide hydrogel, and preparation method and application thereof
  • Dipeptide hydrogel, and preparation method and application thereof
  • Dipeptide hydrogel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Pre-dissolve 2mg of N-fluorenylmethoxycarbonyl-protected tyrosine-aspartic acid dipeptide (Fmoc-YD) in 1uL of hexafluoroisopropanol (HFIP), then add 500uL of water to the system, and place at 40kHz Under ultrasonication for 0.5 minutes, the above mixed solution was aged at 25°C for 24 hours, and Fmoc-YD hydrogel was finally obtained.

[0052] The physical picture of the obtained hydrogel is shown in Figure 1(a). The gel does not flow after being tilted, and the appearance is uniform and transparent. The gel has good ultrasonic responsiveness. After ultrasonication, the gel changes from a gel state to a sol state, and can quickly self-heal in a short time and return to the gel state, such as Figure 1(b) and 1(c) .

Embodiment 2

[0054] Pre-dissolve 4 mg of phenylalanine-aspartic acid (Azo-FD) containing phenyl (Azo-) dipeptide in 5 uL dimethyl sulfoxide (DMSO) solution, add to the DMSO solution of Azo-FD 500uL of water was mixed evenly, and the above mixed solution was ultrasonically placed at 20kHz for 1 minute, and the solution was taken out and aged at 37°C for 48 hours. Finally, Azo-FD hydrogel was obtained.

[0055] Inject the hydrogel onto the glass slide with a syringe as figure 2 , the resulting hydrogel has shear-thinning properties and can be injected.

Embodiment 3

[0057] Weigh 3mg of indole-protected tryptophan-glutamic acid dipeptide derivative Indo-WE and dissolve it in 5uL of dimethylformamide (DMF), then add 1mL of water to the DMF and mix well, put the above solution in After ultrasonication at 35kHz for 2 minutes, take it out, and leave it at 30°C for aging reaction for 72 hours. A dipeptide hydrogel based on Indo-WE was obtained.

[0058] The atomic force picture of the obtained hydrogel is as follows image 3 , the obtained hydrogel is a three-dimensional network structure composed of interwoven fibers.

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Abstract

The invention relates to the field of responding type injectable hydrogels, in particular to a dipeptide hydrogel, a preparation method and application thereof. A dipeptide molecule is of an XY structure, wherein X is selected from tyrosine, phenylalanine, tryptophan or histidine; Y is selected from aspartic acid, asparagine, glutamic acid or glutamine. The hydrogel has a quick ultrasonic response characteristic, can be quickly recovered to a gel state after stimulating response, is stable and uniform in properties, and can be applied to the fields of biological nano-materials, medicament controlled-release, medicament delivery, cell encapsulation and tissue repair.

Description

technical field [0001] The invention relates to the field of responsive injectable hydrogels, in particular to a dipeptide hydrogel, its preparation method and application. Background technique [0002] In recent years, injectable hydrogels have received a lot of attention as biomedical injection materials in the fields of tissue engineering and drug delivery. Injectable hydrogels have the advantages of local drug delivery and long-term drug release at lesion sites. As an ideal hydrogel in the field of biomedicine, it should have the following properties: exhibit good retention viscosity (i.e., shear thinning) under certain pressure; rapidly recover the original gel state (i.e., self-healing) after injection. ; Ability to change from gel to sol with changes in the external environment (ie stimuli responsiveness); biocompatible and biodegradable. [0003] According to different stimulation methods, hydrogels can be divided into two categories: exogenous stimuli-responsive h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/18A61L27/00A61L27/52A61K31/409A61K31/337A61K31/704
CPCA61K9/0024A61K9/06A61K31/337A61K31/409A61K31/704A61K47/183A61L27/00A61L27/52A61L2400/06
Inventor 闫学海邢蕊蕊沈桂芝白硕
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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