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A kind of veterinary amoxicillin granule and preparation method thereof

A technology of amoxicillin and granules, which is applied in the field of veterinary amoxicillin granules, can solve the problems that antibiotics are difficult to exert their efficacy, are not easy to dissolve, and the dosage is difficult to control, so as to achieve the advantages of stability and efficacy Play, solve the problem of dissolution and mixing, and reduce the effect of intestinal residue

Active Publication Date: 2019-04-09
HEBEI LIHUA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when amoxicillin is used in pig farms, the main administration methods are drinking water administration and mixture administration. A large amount of water is needed for drug administration, and the drug is not easy to dissolve and difficult to mix when mixing materials for drug administration. Therefore, it is difficult to control the amount of drug administered during the drug administration process, and it affects drug absorption after drug administration, making it difficult for antibiotic drugs to exert their effects. Some medicinal effects

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] This embodiment relates to veterinary amoxicillin granules and its preparation.

Embodiment 11

[0021] A veterinary amoxicillin granule, its raw material components include: amoxicillin 10g, anhydrous sodium carbonate 5g, sodium bicarbonate 5g, anhydrous glucose 65g, povidone K30 ethanol solution 10ml; wherein povidone K30 and The proportioning of ethanol solution is 1g:6ml, and described ethanol solution is 95% ethanol;

[0022] Weigh the above-mentioned raw material components, and prepare veterinary amoxicillin granules according to the following steps:

[0023] a, preparing adhesive: dissolving povidone K30 in ethanol solution to obtain povidone K30 ethanol solution;

[0024] b. Preparation of soft material: mix amoxicillin, anhydrous sodium carbonate and sodium bicarbonate in sequence according to the ratio, then add anhydrous glucose and mix evenly, then add povidone K30 ethanol solution, and stir for 45 minutes to make soft material ;

[0025] c. Granulation, drying, and granulation: the soft material is granulated on a granulator through a 20-mesh screen, and t...

Embodiment 12

[0027] A kind of amoxicillin granule for veterinary use, its raw material component comprises: amoxicillin 12g, anhydrous sodium carbonate 7g, sodium bicarbonate 7g, anhydrous glucose 75g, povidone K30 ethanol solution 12ml; wherein povidone K30 and The proportioning of ethanol solution is 1g:8ml, and described ethanol solution is 85% ethanol;

[0028] Weigh the above-mentioned raw material components, and prepare veterinary amoxicillin granules according to the following steps:

[0029] a, preparing adhesive: dissolving povidone K30 in ethanol solution to obtain povidone K30 ethanol solution;

[0030] b. Preparation of soft material: mix amoxicillin, anhydrous sodium carbonate and sodium bicarbonate in sequence according to the ratio, then add anhydrous glucose and mix evenly, then add povidone K30 ethanol solution, and stir for 50 minutes to make soft material ;

[0031] c. Granulation, drying, and granulation: the soft material is granulated on a granulator through a 22-m...

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Abstract

The invention discloses an amoxicillin granule for livestock. The amoxicillin granule comprises the following components: 10-20g of amoxicillin, 4-10g of anhydrous sodium carbonate, 4-10g of sodium hydrogen carbonate, 50-80g of anhydrous glucose and 5-20ml of povidone K30 ethanol solution. The obtained amoxicillin granule for livestock has favorable water solubility, and the solubility is greatly improved, thus solving the drug dissolution and uniform mixing problems in water-based drug administration and fodder-based drug administration processes. Meanwhile, the invention also provides a preparation method of the amoxicillin granule for livestock. By defining the mixing sequence of the components as well as the particle size and water content of the granule, the drug stability of the amoxicillin is ensured, the solubility is improved, and the effective dosage during drug administration is ensured. According to the invention, the preparation method is simple in process and low in production cost; and the obtained amoxicillin granule for livestock is high in solubility and has remarkable economic benefits.

Description

technical field [0001] The invention relates to the technical field of medicines and preparation thereof, in particular to a veterinary amoxicillin granule and a preparation method of the veterinary amoxicillin granule. Background technique [0002] Among the many veterinary antibiotics, amoxicillin is widely used and is one of the top ten drugs commonly used in pig farms. It has strong bactericidal effect and high absorption rate in the gastrointestinal tract. It is often used to treat animal respiratory diseases and pig side effects. Haemophilus disease and postpartum infection and other diseases, the curative effect is remarkable. At present, when amoxicillin is used in pig farms, the main administration methods are drinking water administration and mixture administration. A large amount of water is needed for drug administration, and the drug is not easy to dissolve and difficult to mix when mixing materials for drug administration. Therefore, it is difficult to control...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/43A61K47/02A61K47/26A61K47/32A61K47/10A61P31/04
CPCA61K9/1611A61K9/1617A61K9/1623A61K9/1635A61K31/43
Inventor 李晓炫聂思静方庆绕于学康
Owner HEBEI LIHUA PHARMA CO LTD
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