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Antimicrobial microcapsule and preparation method thereof

A technology of microcapsules and formulations, applied in the direction of microcapsule preparations, microsphere preparations, etc., can solve problems such as hindering applications, low water solubility, and easy volatility, and achieve the effects of improving food quality, wide sources, and enhancing shelf life

Inactive Publication Date: 2017-02-01
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main component of clove oil is eugenol, which is a natural antibacterial agent with good antibacterial properties. However, clove oil is volatile in the external environment, sensitive to light and temperature, and has extremely low water solubility, which hinders its antibacterial effect. Application in packaging materials
[0005] At present, there are few reports on the modification of sodium alginate in the industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation and characterization of cholesterol-modified alginic acid derivatives

[0032] Weigh 1g of alginic acid, under the condition of 42℃ water bath, add CaH 2 Stir and dissolve in the dimethyl sulfoxide (DMSO) solution from which water has been removed for 10 hours until the alginic acid dissolves in DMSO and becomes a clear solution. Weigh 0.3g DMAP and 1g DCC, dissolve them in 12mL DMSO solution, and slowly add them dropwise to the reaction solution. Activate for 2 hours. Weigh 0.5g of cholesterol, dissolve it in 5mL of chloroform, slowly add it dropwise to the alginic acid solution, adjust the temperature of the water bath to 35°C and stir for 22h. Pour the obtained solution into five times the volume of ethanol solution, and quickly centrifuge it (4000rpm, 30min), vacuum-dry the precipitate at 0.1MPa, 30°C, and weigh it after drying. Dissolve the dried product in 50mL deionized water, stir to dissolve completely, add an appropriate amount of 1.5% (W / W) ...

Embodiment 2

[0038] (1) Preparation and characterization of cholesterol-modified alginic acid derivatives

[0039] Weigh 1g of alginic acid, under the condition of 42℃ water bath, add CaH2 Stir and dissolve in the dimethyl sulfoxide (DMSO) solution that removes water for 12 hours, until the alginic acid dissolves in DMSO and becomes a clear solution; weigh 0.4g DMAP and 1.2g DCC, dissolve in 15mL DMSO solution, and slowly add dropwise to the reaction solution , activated for 2 hours, weighed 1 g of cholesterol, dissolved it in 5 mL of chloroform, slowly added it dropwise to the alginic acid solution, and adjusted the temperature of the water bath to 37 ° C and stirred for 24 h. Pour the obtained solution into five times the volume of ethanol solution, and quickly centrifuge it (5000rpm, 15min), vacuum-dry the precipitate, and weigh it after drying. Dissolve the dried product in 50mL deionized water, stir to dissolve completely, add an appropriate amount of 2% (W / W) NaHCO 3 , adjust the pH...

Embodiment 3

[0045] (1) Preparation of cholesterol-modified alginic acid derivatives

[0046] Weigh 1g of alginic acid, under the condition of 45℃ water bath, add CaH 2 Stir and dissolve in the dimethyl sulfoxide (DMSO) solution from which water has been removed for 14 hours until the alginic acid dissolves in DMSO and becomes a clear solution. Weigh 0.5g DMAP and 1.4g DCC, dissolve them in 18mL DMSO solution, and slowly add them dropwise to the reaction solution , activated for 2 hours, weighed 0.5g of cholesterol, dissolved it in 15mL of chloroform, slowly added it dropwise to the alginic acid solution, and adjusted the temperature of the water bath to 40°C and stirred for 22h. Pour the obtained solution into 6 times the volume of ethanol solution, and quickly centrifuge it (4500rpm, 20min), dry the precipitate under vacuum at 0.05MPa, 35°C, and weigh it after drying. Dissolve the dried product in 50mL deionized water, stir to dissolve completely, add an appropriate amount of 2.5% (W / W)...

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PUM

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Abstract

The invention relates to an antimicrobial microcapsule and a preparation method thereof and belongs to the technical field of high polymer material modification. Sodium alga acid is used as a main material, cholesterol is used for modifying hydrophilia of the sodium alga acid, and then the sodium alga acid is embedded in clove oil to form the slow-release antimicrobial microcapsule. The preparation method comprises the steps that first, the cholesterol is used for modifying the hydrophilia of the sodium alga acid to form a blank micelle, and then the blank micelle is embedded in the clove oil to form the slow-release antimicrobial microcapsule. The adopted raw materials are all edible, free of harm to a human body, capable of being biodegraded completely after being discarded, free of environmental pollution, simple in technological process and low in production cost; the prepared slow-release antimicrobial microcapsule keeps good stability in the air and a simulated solution, has high antimicrobial performance, can effectively inhibit growth and reproduction of microorganisms and slowly release antimicrobial ingredients in the clove oil over time and has a good slow-release antimicrobial effect.

Description

technical field [0001] The invention relates to an antibacterial microcapsule and a preparation method thereof, belonging to the technical field of polymer material modification. Background technique [0002] Antibacterial microcapsules refer to micro-containers made of polymer materials as wall materials and coated with one or more antibacterial agents (organic, inorganic and composite antibacterial agents). The antibacterial mechanism is controlled release. Since the original properties of the coated material (commonly known as the core material) do not change after the formation of microcapsules, and can be processed or used under conditions such as external pressure, friction, temperature, pH value, enzymes, and combustion, The microcapsules are broken or released through the diffusion of the microcapsule wall, so as to achieve the purpose of sterilization, and some wall materials (such as chitosan) themselves have a bactericidal effect. From the antibacterial mechanism...

Claims

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Application Information

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IPC IPC(8): C08B37/04C08L5/04C08K9/10C08K5/00B01J13/02
CPCC08B37/0084B01J13/02C08J5/18C08J2305/04C08K5/0058C08K9/10C08L5/04C08L2203/16
Inventor 王利强陆敏马淑凤林炎宋会民赵婉怡薛家蓉张贺张晨凤
Owner JIANGNAN UNIV
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