Preparation method of vortex magnetic nanoring sol
A magnetic nanometer and nanoring technology, which is applied in the field of preparation of vortex magnetic nanoring sol, can solve the problems of surface modification and related biological application difficulties, shape distortion and collapse, etc., and achieves uniform size and shape, good crystallinity, High biocompatibility effect
Active Publication Date: 2017-02-08
陕西佰磁康达医疗科技有限公司
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Problems solved by technology
In addition, the γ-Fe obtained by this method 2 o 3 / Fe 3 o 4 Nano-rings, the shape is distorted and collapsed, and there is no surfactant coating, which makes subsequent surface modification of samples and related biological applications difficult
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Embodiment 1
[0025] 70 nm Fe outer diameter 3 o 4 Preparation of Nanoring Vortex Magnetic Sol:
[0026] (1) First synthesize α-Fe with an outer diameter of 70 nm 2 o 3 Nanorings: prepared by a hydrothermal method. 0.8 mL FeCl 3 (0.5M) in water, 0.72 mL NH 4 h 2 PO 4 (0.02M) aqueous solution and 38.5 mL deionized water were mixed in a 50 mL reactor, stirred evenly, and reacted at 220 °C for 48 h. After the reaction is over, wait for the temperature to cool naturally to lower the room temperature, wash 3 times with alcohol and water with a volume ratio of 1:1, and dry to obtain α-Fe 2 o 3 red solid powder;
[0027] (2) The surface is coated with oleic acid to realize the reduction of non-magnetic α-Fe by solution method 2 o 3 Nanoring into Vortex Magnetic Fe 3 o 4 Nano rings: the prepared α-Fe 2 o 3 Nanorings (100 mg) were dispersed in 35 mL trioctylamine solvent and sonicated for 30 min. Add 1 mmol of oleic acid to the above mixture, transfer the resulting solution into ...
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Abstract
The invention relates to a preparation method of a vortex magnetic nanoring sol, that is to say, an alpha-Fe2O3 nanoring powder having no exposed magnetic surface is reduced into a vortex magnetic gamma-Fe2O3 / Fe3O4 nanoring having the surface coated with oleic acid by a solution method, oleic acid is further oxidized into carboxyl having hydrophilia, and the vortex magnetic nanoring sol is obtained. The method has the advantages of simple process and low preparation cost; the prepared vortex magnetic nanoring sol has nanoring size and morphology kept uniform, has the advantages of good crystallinity, stable vortex magnetic domain structure, high saturation magnetization intensity, good magnetic sol dispersity, and high biocompatibility, also realizes carboxyl functionalized modification of the surface of the vortex magnetic nanoring, allows the introduced carboxyl functional groups to be easily combined with antibodies, nucleic acid and drugs, thereby being more widely applied in the biomedical field including specific tumor targeting therapy.
Description
technical field [0001] The invention relates to a preparation method of a vortex magnetic nano ring sol, which belongs to the technical field of preparation of nano functional materials. Background technique [0002] Magnetic nanoparticles, due to their unique nano-size effect and shape-dependent magnetic properties, make them increasingly become research hotspots in biomedical fields such as magnetic resonance imaging, drug delivery, and anti-tumor magnetic hyperthermia. Compared with superparamagnetic iron oxide nanoparticles used clinically, vortex magnetic iron oxide nanorings, due to larger particle size and unique magnetic vortex structure, on the one hand, have a large surface area and high thermochemical stability , high saturation magnetization value and long-term tumor retention time; on the other hand, the unique closed magnetization distribution reduces stray fields, which can effectively weaken the magnetic interaction between particles, so that nanorings can fo...
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IPC IPC(8): C09C1/24C09C3/08A61K47/02A61K45/00A61P35/00B82Y30/00B82Y40/00
CPCA61K45/00A61K47/02B82Y30/00B82Y40/00C01P2006/42C09C1/24C09C3/08
Inventor 樊海明刘晓丽张艺凡
Owner 陕西佰磁康达医疗科技有限公司