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A kind of silk fibroin hydrogel for skin care and preparation method thereof

A technology of silk fibroin and hydrogel, applied in skin care preparations, cosmetic preparations, pharmaceutical formulations, etc., can solve the problems of not using silk, and achieve a wide range of applications, good biocompatibility and bioavailability Absorbency, easy to store for a long time

Active Publication Date: 2020-08-07
药谷(温州)科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although numerous face masks using silk have been developed, there is no mask that utilizes the beneficial properties of silk

Method used

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  • A kind of silk fibroin hydrogel for skin care and preparation method thereof
  • A kind of silk fibroin hydrogel for skin care and preparation method thereof
  • A kind of silk fibroin hydrogel for skin care and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of silk fibroin hydrogel

[0022] According to the composition of each experimental group and control group of silk fibroin hydrogel in Table 1, weigh each component, dissolve additional components such as active factors and stabilizers to form an aqueous solution, add silk fibroin, snail mucin, sterol and vitamin C, stirred evenly, freeze-dried to remove water, gamma-ray irradiated and sterilized, sealed and stored, and added with clean water to dissolve before use to form a silk fibroin hydrogel solution.

[0023] Table 1 Composition of each experimental group of silk fibroin hydrogel

[0024]

[0025]

[0026] Note: " / " means that this component is 0; the content in brackets after the number under "sterol" refers to the specific name of sterol.

Embodiment 2

[0027] Performance detection and application effect of embodiment 2 silk fibroin hydrogel

[0028] (1) Determination of swelling rate

[0029] The hydrogels prepared by each experimental group and control group in Example 1 were spread into a film, cut into a size of 0.07cm × 1.2cm × 4cm after drying, completely dried in an oven at 80°C, and then each group was again The film samples were immersed in water to make them swell, and the swelling rate of each sample was calculated according to the following formula to evaluate the water retention capacity of the silk fibroin hydrogel.

[0030] Swelling rate=(initial weight-dry weight) / initial weight×100

[0031] (2) Determination of tensile strength

[0032] The hydrogels prepared by each experimental group and control group in Example 1 were spread into a film, dried and cut into a size of 1.0 cm×8.0 cm×0.07 cm. In the tensile tester (MInimat type testing machine of U.S. Rheometric Scientific company), it is 10mm / min to apply ...

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Abstract

The invention provides skin-care fibroin hydrogel and a preparation method thereof. The skin-care fibroin hydrogel comprises the following main components: fibroin, hyaluronic acid, snail mucin, sterol and vitamin C; the mechanical strength and the degradation rate of the fibroin hydrogel can be controlled by changing the matching ratio of the components; the fibroin hydrogel has good mechanical elasticity, improves the water retention of skin, promotes the metabolism of the skin surface, has wrinkle-resisting, nourishing and beautifying effects, can be used as a matrix of skin-care cream, a mask and other skin-care products for whole body skin, and can also be directly smeared or sprayed onto the skin surface for beautifying the skin.

Description

technical field [0001] The invention relates to a silk fibroin hydrogel and a preparation method thereof, in particular to a skin care silk fibroin hydrogel with anti-wrinkle, nourishing and beautifying effects and a preparation method thereof. Background technique [0002] Recently, skin care using hydrogel has been widely used in various aspects in the field of cosmetics, skin care products, or the like. Considering the effect, activity and dosage form of the hydrogel mask, the hydrogel mask is evaluated as the form with the most cutting-edge technology. The hydrogel mask is a skin care delivery system designed to store the cosmetic material in a polymer by cross-linking the cosmetic material with a water-soluble polymer in the hydrogel or by using the carrier properties of the polymer The effect and activity of active ingredients of active cosmetic materials are transferred continuously and efficiently. Compared with sheet mask types including a non-woven fabric impregn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/04A61K8/73A61K8/64A61K8/63A61K8/67A61Q19/08A61Q19/00
CPCA61K8/042A61K8/63A61K8/64A61K8/676A61K8/735A61Q19/00A61Q19/08
Inventor 赵应征鲁翠涛肖健徐荷林杨伟虞希冲傅红兴胡淑平姜义娜
Owner 药谷(温州)科技发展有限公司
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