Method for preparing liquid bandage for war wounds

A technology for liquid bandages and trauma, applied in bandages, medical science, etc., can solve the problems of not being able to meet the requirements of first aid for trauma, and achieve the effects of good stability, good biocompatibility, and low cost

Inactive Publication Date: 2017-03-08
南京盛骏医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although this hydrogel is functionally satisfactory, how fast and how good it ...

Method used

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  • Method for preparing liquid bandage for war wounds
  • Method for preparing liquid bandage for war wounds
  • Method for preparing liquid bandage for war wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of thiol-containing acid derivative H-1:

[0025] Dissolve 10 grams of hyaluronic acid in 1 L of distilled water. Then add 12 grams of dithiodimalonyl hydrazide, fully stir to dissolve. Adjust the pH value of the above solution to 4.75 with 0.1mol / L dilute hydrochloric acid, then add 19.2 grams of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and continue stirring to fully dissolve it . React for 12 hours, and keep the pH value of the reaction solution at 4.75.

[0026] Use 1.0mol / L sodium hydroxide solution to adjust the pH of the solution in 1 to 7.0, then add 50 grams of dithiothreitol, and adjust the pH of the solution to 8.5. After reacting at room temperature for 24 hours, the pH of the solution was adjusted to 3.5 with 1 mol / L hydrochloric acid. Then put the sample into a dialysis bag for dialysis (molecular weight cut-off 3500), use pure water for dialysis for 4-5 days, and change the dialysis solution every 8 hours. Finally, the ...

Embodiment 2

[0028] Preparation of polyethylene glycol derivative PEG-2 containing dimethacrylic acid:

[0029] Add 4g of polyethylene glycol to 50mL of dichloromethane, then add 1g of triethylamine, and cool the mixture to 0°C. Then, a dichloromethane solution of 1 g of methacryloyl chloride was added dropwise into the reaction system, and the reaction was continuously stirred for 12 hours. The final product was finally obtained by three times of dichloromethane dissolution and ether precipitation purification.

Embodiment 3

[0031] Preparation of polyethylene glycol derivative PEG-4 containing tetramethacrylic acid:

[0032] Add 4g of polyethylene glycol to 50mL of dichloromethane, then add 1g of triethylamine, and cool the mixture to 0°C. Then, a dichloromethane solution of 1 g of methacryloyl chloride was added dropwise into the reaction system, and the reaction was continuously stirred for 12 hours. Then put the sample into a dialysis bag for dialysis (molecular weight cut-off 3500), use pure water for dialysis for 4 days, and change the dialysis solution every 8 hours. Finally, the solution in the dialysis tube was collected and freeze-dried to obtain a white flocculent solid.

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Abstract

The invention discloses a method for preparing a liquid bandage for war wounds. The method is characterized by comprising the following steps: 1, dissolving a mercapto-hyaluronic acid derivative, a tackifier, a humectant and a preservative into de-ionized water to form a component A; 2, dissolving an acrylic ester derivative and the preservative into de-ionized water, and adding a borate buffer solution to form a component B; 3, spraying the component A onto the surface of a wound, then spraying the component B to the surface of the wound, and fast generating cross-linking within 10 seconds to form the liquid bandage for the war wounds. The prepared liquid bandage for the war wounds is high in biocompatibility, free of skin irritation and cytotoxicity and applicable to relatively small war wounds such as gunshot wounds, burns and cuts. The preparation method is simple and fast, and has high practical value.

Description

technical field [0001] The invention relates to a method for preparing a liquid bandage for war wounds, in particular to a method for preparing a liquid bandage suitable for war wounds such as gunshot wounds, burns and cuts with smaller wounds. Background technique [0002] In the period of modern warfare, various types of burns have increased, mostly in the form of compound injuries, and there are many wounds. For war wounds, the widely used traditional bandage (gauze) mainly uses cotton yarn as the base material, and its main function is to bandage the wound or stop bleeding. The traditional bandage is cumbersome to bandage the wound, and consumes about tens of thousands of tons of cotton yarn every year. As a deformation of the traditional bandage-ordinary band-aid is composed of gauze, rubber adhesive and effective drug ingredients attached to the rubber adhesive. The gauze plays the role of a support and has the function of absorbing wound exudate; the rubber adhesive...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0061A61L26/0023A61L26/008C08L5/08
Inventor 谢和辉邱彦仲伯蒙王亚威
Owner 南京盛骏医疗科技有限公司
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