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Sodium-alginate-based hydrogel and preparation method thereof

A technology for sodium alginate and sodium alginate oxidation, applied in the field of polymer materials, can solve problems such as loss of gel properties and easy dissolution, and achieve the effects of good healing ability, easy availability of raw materials, and easy realization.

Active Publication Date: 2017-03-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Sodium alginate can interact with divalent ions such as Ca 2+ , Zn 2+ 、Cu 2+ Form ionic hydrogel, but the divalent ions in it are easy to ion exchange with the ions in the surrounding environment medium of the gel, so it is easy to dissolve in the physiological environment and lose the gel properties

Method used

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  • Sodium-alginate-based hydrogel and preparation method thereof
  • Sodium-alginate-based hydrogel and preparation method thereof
  • Sodium-alginate-based hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The specific steps for preparing sodium alginate-based hydrogel are as follows:

[0042] 1) Preparation of oxidized sodium alginate: Add 5.001g sodium alginate to 25mL n-propanol to form a sodium alginate-n-propanol suspension with a concentration of 200g / L, and add 25ml 1.0mol / L peroxide in turn Hydrogen solution and 4ml 6.0mol / L acetic acid solution were stirred and reacted for 2h at 8°C in the dark, 5ml ethylene glycol was added to react for 30min, then 0.7g NaCl was added, and the reaction was terminated after 30min. The reaction product was dialyzed in deionized water with a dialysis bag, and the water was changed twice a day. After dialysis for 2 days, it was freeze-dried to obtain oxidized sodium alginate with an oxidation degree of 73.81%.

[0043] 2) Preparation of sodium alginate with amino groups: 1.0002g (0.005mol) of sodium alginate in 100mL deionized water was prepared into a sodium alginate solution with a concentration of 10g / L, and the sodium alginate soluti...

Embodiment 2

[0049] The specific steps for preparing sodium alginate-based hydrogel are as follows:

[0050] 1) Preparation of oxidized sodium alginate: add 2.5003g sodium alginate to 25mL n-propanol to prepare a 100g / L sodium alginate-n-propanol suspension, and add 25ml 0.3mol / L high iodine sequentially Sodium aqueous solution and 12ml 1.0mol / L sulfuric acid solution were stirred and reacted at 15°C in the dark for 6h, 5ml ethylene glycol was added to react for 30min, then 0.7g NaCl was added, and the reaction was terminated after 30min. The reaction product was dialyzed in deionized water with a dialysis bag, the water was changed twice a day, and lyophilized after 2 days of dialysis to obtain oxidized sodium alginate with an oxidation degree of 53.82%;

[0051] 2) Preparation of sodium alginate with amino groups: 0.5002g (0.0025mol) of sodium alginate in 100mL deionized water, mixed with a concentration of 50g / L sodium alginate solution, adjust the sodium alginate solution with 1mol / L dilute...

Embodiment 3

[0055] The specific steps for preparing sodium alginate-based hydrogel are as follows:

[0056] 1) Preparation of oxidized sodium alginate: add 1.0000g sodium alginate to 25mL n-propanol to prepare a 4% (w / v) sodium alginate-n-propanol suspension, and add 25ml 0.1mol / L After sodium periodate aqueous solution and 6ml 4.0mol / L dilute hydrochloric acid solution were stirred and reacted at 25°C in the dark for 12h, 5ml ethylene glycol was added to react for 30min, then 0.7g NaCl was added, and the reaction was terminated after 30min. The reaction product was dialyzed in deionized water with a dialysis bag, the water was changed twice a day, and lyophilized after 2 days of dialysis to obtain oxidized sodium alginate with an oxidation degree of 36.64%;

[0057] 2) Preparation of sodium alginate with amino groups: Dissolve 2.0001 g of sodium alginate (0.010mol) in 100mL of deionized water, make a 2% (w / v) sodium alginate solution, adjust with 1mol / L dilute hydrochloric acid Sodium algina...

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Abstract

The invention relates to sodium-alginate-based hydrogel and a preparation method thereof. The sodium-alginate-based hydrogel is prepared through steps as follows: 1) 100-300 mg of aminated sodium alginate, 20-100 mg of L-lysine or 25-120 mg of L-arginine or 18-90 mg of L-ornithine and 20-100 mg of nano ferroferric oxide magnetic particles are dissolved in a PBS solution; 2) 50-300 mg of oxidized sodium alginate is dissolved in a borax solution; 3) solutions obtained in steps 1) and 2) are mixed and stirred and react at the constant temperature of 25-40 DEG C for 0.5-24 h, and the sodium-alginate-based hydrogel is obtained. Oxidized sodium alginate is prepared by reacting sodium alginate with an oxidizing agent under the acid condition, and aminated sodium alginate is prepared by modifying sodium alginate with a diamine compounds. The prepared sodium-alginate-based hydrogel has the advantages of being injectable, self-healing, degradable, good in biocompatibility and the like, raw material sources are wide, the preparation process is simple, and industrial production is facilitated.

Description

Technical field [0001] The invention relates to a sodium alginate-based hydrogel and a preparation method and application thereof, belonging to the field of polymer materials. [0002] technical background [0003] Hydrogel is a polymer material that can swell in water but is insoluble in water. It forms a three-dimensional network structure through intermolecular cross-linking, and its molecular chain has hydrophilic groups. It is generally believed that hydrogels have good biocompatibility because they contain a large amount of water, which is very similar to body tissues filled with aqueous liquids. With the development of modern technology, hydrogels have many applications in the fields of drug controlled release, tissue engineering, and organ regeneration. However, in the prior art, the self-healing ability and efficiency of hydrogels are still low and need to be improved. [0004] Sodium alginate is a natural polymer of polysaccharides, which is soluble in water but insoluble...

Claims

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Application Information

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IPC IPC(8): C08L5/04C08K3/22C08K5/17C08J3/075C08B37/04
CPCC08B37/0084C08J3/075C08J2305/04C08J2405/04C08K2201/003C08K2201/011C08L5/04C08L2205/025C08K2003/2275C08K5/175
Inventor 戴红莲焦佳佳徐超康海飞
Owner WUHAN UNIV OF TECH
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