Sodium-alginate-based hydrogel and preparation method thereof

A technology for sodium alginate and sodium alginate oxidation, applied in the field of polymer materials, can solve problems such as loss of gel properties and easy dissolution, and achieve the effects of good healing ability, easy availability of raw materials, and easy realization.
CN106478995AActive Publication Date: 2017-03-08WUHAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUHAN UNIV OF TECH
Publication Date
2017-03-08

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Abstract

The invention relates to sodium-alginate-based hydrogel and a preparation method thereof. The sodium-alginate-based hydrogel is prepared through steps as follows: 1) 100-300 mg of aminated sodium alginate, 20-100 mg of L-lysine or 25-120 mg of L-arginine or 18-90 mg of L-ornithine and 20-100 mg of nano ferroferric oxide magnetic particles are dissolved in a PBS solution; 2) 50-300 mg of oxidized sodium alginate is dissolved in a borax solution; 3) solutions obtained in steps 1) and 2) are mixed and stirred and react at the constant temperature of 25-40 DEG C for 0.5-24 h, and the sodium-alginate-based hydrogel is obtained. Oxidized sodium alginate is prepared by reacting sodium alginate with an oxidizing agent under the acid condition, and aminated sodium alginate is prepared by modifying sodium alginate with a diamine compounds. The prepared sodium-alginate-based hydrogel has the advantages of being injectable, self-healing, degradable, good in biocompatibility and the like, raw material sources are wide, the preparation process is simple, and industrial production is facilitated.
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Description

Technical field

[0001] The invention relates to a sodium alginate-based hydrogel and a preparation method and application thereof, belonging to the field of polymer materials.

[0002] technical background

[0003] Hydrogel is a polymer material that can swell in water but is insoluble in water. It forms a three-dimensional network structure through intermolecular cross-linking, and its molecular chain has hydrophilic groups. It is generally believed that hydrogels have good biocompatibility because they contain a large amount of water, which is very similar to body tissues filled with aqueous liquids. With the development of modern technology, hydrogels have many applications in the fields of drug controlled release, tissue engineering, and organ regeneration. However, in the prior art, the self-healing ability and efficiency of hydrogels are still low and need to be improved.

[0004] Sodium alginate is a natural polymer of polysaccharides, which is soluble in water but insoluble...

Claims

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