Antimicrobial macromolecule with biocompatibility

A biocompatible and antimicrobial technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, anti-infective drugs, etc., can solve the problem of inability to kill bacteria, limited application range, and inability to apply microbial wound disinfection and anti-infection , Disinfection of medical equipment and environmental disinfection

Active Publication Date: 2017-03-15
克灵美(天津)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application range is limited because of its toxic and side effects and its small antimicrobial spectrum, short-acting and limited ability to kill microorganisms
The natural antibacterial materials or polymer quaternary ammonium salt antibacterial materials currently reported are less toxic, but their antibacterial performance is too mild. Died from a medically salvageable secondary infection
Chitooligosaccharide quaternary ammonium salt as disclosed in patent CN201110068952.3 and CN201510761923.3 flocculant carboxymethyl chitosan quaternary ammonium salt all have certain antibacterial effect, but can not kill bacteria, therefore, cannot be applied to require strict killing Anti-microbial, wound disinfection and anti-infection, medical device disinfection and environmental disinfection without toxic side effects on biological organisms

Method used

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  • Antimicrobial macromolecule with biocompatibility
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  • Antimicrobial macromolecule with biocompatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A preparation method of a biocompatible antimicrobial polymer:

[0051] In the first step, DMF, hydroxyethyl methacrylate and initiator are respectively added into a round bottom flask equipped with mechanical stirring, wherein the concentration of the initiator is 2wt%. The mixed system was reacted at 65° C. for 24 hours. After the reaction, the product was precipitated with ether and washed to obtain a polymer intermediate.

[0052] In the second step, the polymer intermediate in the first step is reacted with 5-chloro-1-pentene under acid catalysis to obtain a graft polymer. In the acetonitrile solvent, the grafted polymer and the tertiary amine are refluxed for 24 hours, extracted, concentrated and dried under reduced pressure to obtain a biocompatible antimicrobial macromolecule.

[0053] The biocompatible antimicrobial macromolecule prepared by the present invention has a straight-chain polyhydroxyethyl acrylate macromolecule as a skeleton, has a molecular weight...

Embodiment 2

[0055] A preparation method of a biocompatible antimicrobial polymer:

[0056] In the first step, add 0.1mol methacrylic acid and 0.3mol pentaethylene glycol and 400mL toluene to a round bottom flask, reflux under organic acid catalysis, react for 24 hours, cool to room temperature, extract and concentrate under reduced pressure to obtain intermediate product.

[0057]In the second step, the intermediate product of the first step, DMF, hydroxyethyl methacrylate and initiator are respectively added in a round bottom flask equipped with mechanical stirring, wherein the intermediate product of the first step and hydroxyethyl methacrylate The ratio of the amount of substances is 2:8, and the initiator concentration is 2wt%. The mixed system was reacted at 65° C. for 24 hours. After the reaction, the product was precipitated with ether and washed to obtain a polymer intermediate.

[0058] The third step is the graft polymer obtained by reacting the polymer intermediate in the sec...

Embodiment 3

[0061] A preparation method of a biocompatible antimicrobial polymer:

[0062] In the first step, add 0.1mol methacrylic acid and 0.3mol pentaethylene glycol and 400mL toluene to a round bottom flask, reflux under organic acid catalysis, react for 24 hours, cool to room temperature, extract and concentrate under reduced pressure to obtain intermediate product.

[0063] In the second step, the intermediate product of the first step, DMF, hydroxyethyl methacrylate and initiator are respectively added in a round bottom flask equipped with mechanical stirring, wherein the intermediate product of the first step and hydroxyethyl methacrylate The ratio of the amount of substances is 4:6, and the initiator concentration is 2wt%. The mixed system was reacted at 65° C. for 24 hours. After the reaction, the product was precipitated with ether and washed to obtain a polymer intermediate.

[0064] The third step is the graft polymer obtained by reacting the polymer intermediate in the se...

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Abstract

The invention relates to an antimicrobial macromolecule with biocompatibility. The antimicrobial macromolecule with biocompatibility comprises a macromolecular framework, an antimicrobial functional group branched chain and a biocompatibility functional group branched chain. The antimicrobial functional group branched chain and the biocompatibility functional group branched chain are grafted on the macromolecular framework, and the molar ratio of the antimicrobial functional group branched chain to the biocompatibility functional group branched chain is 1,000:1 to 1:1,000. The grafting rate of the antimicrobial functional group branched chain is 0.001%-99.999%. The prepared antimicrobial macromolecule with biocompatibility has the advantages of selectively resisting microorganisms and having no toxic and side effects on animal organism cells and tissue, resists microorganisms in a broad-spectrum, efficient and longlasting manner, has inhibiting and killing effects on gram positive bacteria, gram negative bacteria, fungi, mould, viruses and the like, and is suitable for large-scale application in various relevant fields such as the disinfection antimicrobial field.

Description

technical field [0001] The invention belongs to the technical field of antimicrobial polymer materials, and relates to an antimicrobial polymer with biocompatibility. Microbial polymers. Background technique [0002] Bacterial infections can be seen everywhere at any time, and the number of people who die from bacterial infections in the world far exceeds the number of deaths caused by diseases or other causes every year. There are also staggering anti-infection costs and the market for anti-microbial and anti-infection materials. However, the antimicrobial disinfection products currently on the market have single functions and narrow protective surfaces, so they cannot be applied to the acute treatment of bleeding wounds or wounds. With the economic recovery and the prosperity of emerging markets, as well as the growth of the national middle-income consumers' demand for the environment, medical sanitation, and health care services, the market for antimicrobial and antimicr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F265/04C08F120/28C08F220/28C08F220/06C08F214/14C08B37/00C08B37/08C08G61/12A61K31/785A61K31/732A61P31/00A61P17/02
CPCA61K31/732A61K31/785C08B37/003C08B37/0033C08F120/28C08F220/06C08F220/28C08F220/281C08F265/04C08G61/125C08G2261/3222C08F214/14
Inventor 曾小梅陈江敏文学军
Owner 克灵美(天津)生物科技有限公司
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