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Preparation method of beta-tricalcium phosphate nanometer coating

A technology of tricalcium phosphate nanometer and tricalcium phosphate, which is applied in the direction of coating, electrolytic coating, electrophoretic plating, etc., can solve the problems of high equipment price, high requirements for preparation environment conditions, and complicated operation, so as to enhance the binding force and avoid Phase change and embrittlement, energy saving effect

Active Publication Date: 2017-04-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Common methods for preparing β-TCP coatings include plasma spraying, physical and chemical vapor deposition, electrophoretic deposition, powder metallurgy, etc. However, methods such as plasma spraying, physical and chemical vapor deposition, and powder metallurgy have high equipment prices, poor coating stability, Deficiencies such as high requirements for the preparation environment and complicated operation

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  • Preparation method of beta-tricalcium phosphate nanometer coating
  • Preparation method of beta-tricalcium phosphate nanometer coating
  • Preparation method of beta-tricalcium phosphate nanometer coating

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Embodiment 1

[0045] The preparation of the β-TCP nano coating of the present embodiment may further comprise the steps:

[0046] (1) With 0.45mol / L Ca(NO 3 ) 2 4H 2 O solution is calcium source, 0.5mol / L (NH 4 ) 2 HPO 4 The solution is a phosphorus source, adjust the amount of calcium source and phosphorus source to control the molar ratio of Ca / P to 1.5; add the dispersant polyethylene glycol to the calcium source and stir evenly; adjust the pH of the phosphorus source solution to 9.0 with ammonia water; adjust the pH The final phosphorus source solution was added dropwise to the calcium source solution under the condition of stirring at 400r / min. During the dropwise addition, the pH of the reaction solution system was kept at 7.0. After the dropwise addition, continued to stir for 10h, aged for 2d, and filtered. Wash with deionized water until the pH of the supernatant is 7.0, freeze-dry, and calcinate at 800°C for 3 hours to obtain β-TCP powder;

[0047] figure 1 It is the XRD pa...

Embodiment 2

[0057] The preparation of the β-TCP nano coating of the present embodiment may further comprise the steps:

[0058] (1) With 0.45mol / L Ca(NO 3 ) 2 4H 2 O solution is calcium source, 0.5mol / L (NH 4 ) 2 HPO 4 The solution is a phosphorus source, adjust the amount of calcium source and phosphorus source to control the molar ratio of Ca / P to 1.5; add the dispersant polyethylene glycol to the calcium source and stir evenly; adjust the pH of the phosphorus source solution to 9.0 with ammonia water; The solution was added dropwise to the calcium source solution under the condition of stirring at 400r / min. During the dropwise addition, the pH of the reaction solution system was kept at 7.0. After the dropwise addition, continued stirring for 10h, aging for 2d, filtering, and using Washing until the pH of the supernatant is 7.0, freeze-drying, and calcining at 800°C for 3 hours to obtain β-TCP powder;

[0059] (2) Weigh the prepared β-TCP powder and add it into ethanol to prepare...

Embodiment 3

[0068] The β-TCP nano-coating obtained by electrophoretic deposition for 5min under 25V / cm electric field strength is used for QCM-D technology, and the adsorption behavior of bovine serum albumin (BSA) on it is studied, comprising the following steps:

[0069] (1) The preparation of β-TCP nano-coating is the same as in Example 1, and the electrophoretic deposition time is 5min;

[0070] (2) Using QCM-D technology to study the adsorption behavior of bovine serum albumin (BSA) on the β-TCP nano-coating, BSA was dissolved in PBS buffer solution to prepare a 1mg / ml bovine serum albumin solution. During the experiment The PBS buffer solution was introduced first, and then the BSA solution was introduced after the baseline equilibrium was stable, and the adsorption was observed until the adsorption reached equilibrium.

[0071] Figure 9 and Figure 10 The frequency Δf and dissipation value ΔD of BSA adsorbed on the β-TCP nano-coating vary with time, respectively. It can be seen ...

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Abstract

The invention discloses a preparation method of a beta-tricalcium phosphate nanometer coating. The preparation method comprises the following steps: (1) adding dispersant in a calcium source solution, uniformly stirring, adding a phosphorus source solution dropwise, and continuously stirring, ageing, filtering, washing, freezing, drying and calcining the mixture to obtain a beta-tricalcium phosphate powder; (2) adding the prepared beta-tricalcium phosphate powder in ethanol, carrying out ball milling and standing to prepare a stable beta-tricalcium phosphate suspension; and (3) taking a gold sheet as a working electrode, a platinum electrode as a counter electrode and the beta-tricalcium phosphate suspension as an electrolyte, applying direct current between the electrodes, and carrying out electrophoretic deposition on the surface of the gold sheet to obtain the beta-tricalcium phosphate nanometer coating. According to the preparation method, phase change and embrittlement caused in the high temperature process are prevented, the binding force of substrate metal and the beta-tricalcium phosphate nanometer coating is strengthened, the energy is saved, and the roughness of the beta-tricalcium phosphate nanometer coating can be controlled by controlling the electric field intensity and the time of electrophoretic deposition.

Description

technical field [0001] The invention relates to the preparation of a calcium phosphate ceramic coating, in particular to a preparation method of a β-tricalcium phosphate nano coating. Background technique [0002] β-tricalcium phosphate (β-TCP) has good biocompatibility, osteoconduction and biodegradability, and is widely used in biomedical materials. It has good biocompatibility, and it degrades after being implanted in the body. The degraded Ca and P enter the circulatory system of the organism to form new bone. replace. β-TCP is superior to hydroxyapatite in bone formation speed, and is an ideal material for repairing hard tissue defects with attractive clinical application prospects. [0003] However, due to the poor mechanical properties and high brittleness of β-TCP ceramic materials, the anti-fatigue and anti-destructive strength in the physiological environment are not high, so it is difficult to apply to the situation that needs to bear the load. Metal materials ...

Claims

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Application Information

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IPC IPC(8): C25D13/02
CPCC25D13/02
Inventor 邓春林庞栋文
Owner SOUTH CHINA UNIV OF TECH
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